在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UBASH3A Antibody

  • 中文名稱:
    UBASH3A兔多克隆抗體
  • 貨號:
    CSB-PA785075
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from LOVO cells, HuvEc cells and K562 cells, using UBASH3A antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UBASH3A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    UBASH3A
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human UBASH3A.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
  • 基因功能參考文獻:
    1. UBASH3A gene SNP is associated with susceptibility to atopic dermatitis in Chinese Han population. PMID: 28747736
    2. UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppressing the activation of the IkappaB kinase complex. UBASH3A interacts with TAK1 and NEMO, suggesting that UBASH3A regulates the NF-kappaB signaling pathway by an ubiquitin-dependent mechanism. T1D risk alleles at rs11203203 and rs80054410 increase UBASH3A expression in CD4(+) T cells upon TCR stimulation. PMID: 28607106
    3. A negative correlation was found between UBASH3A mRNA expression and systemic lupus erythematosus. PMID: 25876712
    4. Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease. PMID: 25843625
    5. these results have suggested that the allele A of two SNPs may play no role in the pathogenesis of autoimmune thyroid disease or that its effect may be confounded by other various factors. PMID: 25211447
    6. Addition of PTPN22 and UBASH3A SNPs to HLA-DR,DQ genotyping can improve type 1 diabetes risk prediction. PMID: 25075402
    7. Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases. PMID: 23565265
    8. ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype PMID: 22776074
    9. The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    10. Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases PMID: 15159412
    11. TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin PMID: 17382318
    12. TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors PMID: 17709377
    13. Binds to ABCE-1 and inhibits HIV-1 life cycle, most likely by disrupting essential ubiquitylation-dependent events. PMID: 18006034
    14. TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk PMID: 18189269

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 組織特異性:
    Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
  • 數據庫鏈接:

    HGNC: 12462

    OMIM: 605736

    KEGG: hsa:53347

    STRING: 9606.ENSP00000317327

    UniGene: Hs.473912



主站蜘蛛池模板: 国产成人av无码永久免费一线天| 婷婷无套内射影院| 欧美熟妇丰满肥白大屁股免费视频| 精品久久久久久中文墓无码| 精品国产成人高清在线观看| 男人扒开女人腿桶到爽免费| 51精品国产人成在线观看| 久久99精品国产99久久6尤物| 亚洲午夜无码久久久久蜜臀av| 韩国三级无码hd中文字幕| 波多野结衣乳巨码无在线| 高潮喷水的毛片| 人妻夜夜爽天天爽三区| 无码国内精品人妻少妇| 卡1卡2卡3精品接入口| 久久这里有精品国产电影网| 亚洲色欧美色2019在线| 香蕉久久一区二区三区啪啪| 三级久久试看3分钟| 熟妇无码熟妇毛片| 妺妺窝人体色www看人体| 精品国产乱码久久久久久免费| 人人模人人爽人人喊久久| 亚洲sm另类一区二区三区| 欧美日韩精品| 麻豆av一区二区三区久久| 精品亚洲欧美自拍| 在线视频国产网址你懂的| 国产一区二区三区精品视频| 久久无码专区国产精品s| 亚洲 日韩 国产 中文有码| 亚洲中文字幕人成乱码| 国产麻豆剧果冻传媒白晶晶| 亚洲欧美另类久久久精品能播放的| 久久精品国产曰本波多野结衣| 青乐娱精品视频一国产分类| 人人超人人超碰超国产| 久久亚洲中文字幕无码| 亚洲人成网站18禁止人| 丁香五月综合久久激情| 日韩人妻无码精品-专区|