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UBASH3A Antibody, HRP conjugated

  • 中文名稱:
    UBASH3A兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA025427LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UBASH3A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    UBASH3A
  • 別名:
    Cbl interacting protein 4 antibody; Cbl-interacting protein 4 antibody; CLIP4 antibody; STS 2 antibody; STS-2 antibody; Suppressor of T cell receptor signaling 2 antibody; Suppressor of T-cell receptor signaling 2 antibody; T cell ubiquitin ligand antibody; T cell ubiquitin ligand protein antibody; T-cell ubiquitin ligand 1 antibody; TULA antibody; TULA-1 antibody; UBASH3A antibody; ubiquitin associated and SH3 domain containing, A antibody; Ubiquitin-associated and SH3 domain-containing protein A antibody; UBS3A_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ubiquitin-associated and SH3 domain-containing protein A protein (287-455AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
  • 基因功能參考文獻:
    1. UBASH3A gene SNP is associated with susceptibility to atopic dermatitis in Chinese Han population. PMID: 28747736
    2. UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppressing the activation of the IkappaB kinase complex. UBASH3A interacts with TAK1 and NEMO, suggesting that UBASH3A regulates the NF-kappaB signaling pathway by an ubiquitin-dependent mechanism. T1D risk alleles at rs11203203 and rs80054410 increase UBASH3A expression in CD4(+) T cells upon TCR stimulation. PMID: 28607106
    3. A negative correlation was found between UBASH3A mRNA expression and systemic lupus erythematosus. PMID: 25876712
    4. Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease. PMID: 25843625
    5. these results have suggested that the allele A of two SNPs may play no role in the pathogenesis of autoimmune thyroid disease or that its effect may be confounded by other various factors. PMID: 25211447
    6. Addition of PTPN22 and UBASH3A SNPs to HLA-DR,DQ genotyping can improve type 1 diabetes risk prediction. PMID: 25075402
    7. Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases. PMID: 23565265
    8. ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype PMID: 22776074
    9. The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    10. Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases PMID: 15159412
    11. TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin PMID: 17382318
    12. TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors PMID: 17709377
    13. Binds to ABCE-1 and inhibits HIV-1 life cycle, most likely by disrupting essential ubiquitylation-dependent events. PMID: 18006034
    14. TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk PMID: 18189269

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  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 組織特異性:
    Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
  • 數據庫鏈接:

    HGNC: 12462

    OMIM: 605736

    KEGG: hsa:53347

    STRING: 9606.ENSP00000317327

    UniGene: Hs.473912



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