在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UBA1 Antibody

  • 中文名稱:
    UBA1兔多克隆抗體
  • 貨號:
    CSB-PA186952
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA186952(UBA1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hepg2, Jurkat, 231 and hela cell, Primary antibody: CSB-PA186952(UBA1 Antibody) at dilution 1/450 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    A1S9 antibody; A1S9 protein antibody; A1S9T and BN75 temperature sensitivity complementing antibody; A1S9T antibody; A1ST antibody; AMCX1 antibody; CFAP124 antibody; CTD-2522E6.1 antibody; GXP 1 antibody; GXP1 antibody; MGC4781 antibody; POC20 antibody; POC20 centriolar protein homolog antibody; Protein A1S9 antibody; SMAX2 antibody; Uba1 antibody; UBA1, ubiquitin-activating enzyme E1 homolog A antibody; UBA1_HUMAN antibody; UBA1A antibody; UBE 1 antibody; UBE 1X antibody; UBE1 antibody; UBE1X antibody; Ubiquitin activating enzyme E1 antibody; Ubiquitin-activating enzyme E1 antibody; Ubiquitin-like modifier-activating enzyme 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human UBA1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
  • 基因功能參考文獻:
    1. Polyubiquitination and proteasomal degradation of ezrin and CUGBP1 require Uba6, but not Uba1, and that Uba6 is involved in the control of ezrin localization and epithelial morphogenesis. These data suggest that distinctive substrate pools exist for Uba1 and Uba6 that reflect non-redundant biological roles for Uba6. PMID: 28134249
    2. Results from a study on gene expression variability markers in early-stage human embryos shows that UBA1 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    3. recent findings put UBA1 at the center of cellular homeostasis and neurodegeneration [review] PMID: 26432019
    4. A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes. PMID: 25207809
    5. Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation PMID: 25768649
    6. Ubiquitin-activating enzyme is necessary for 17beta-estradiol-induced breast cancer cell proliferation and migration. PMID: 25138535
    7. We expressed and purified the N-terminal domains of human E1 and determined their crystal structures, which contain inactive adenylation domain (IAD) and the first catalytic cysteine half-domain (FCCH) PMID: 25209502
    8. Diminished ubiquitylation phenotype observed in enteropathogenic Escherichia coli infected cells corresponds to a strong reduction in the abundance of both Ube1 and Uba6. PMID: 22999844
    9. Decrease in free ubiquitin levels under stress allows NEDD8 to be conjugated through Ube1. PMID: 22370482
    10. UBA1 knockdown impairs formation of ubiquitin conjugates at DNA double-strand breaks. PMID: 22456334
    11. Data show that largazole and ester/keto analogs inhibit ubiquitin E1 activation. PMID: 22279528
    12. In conclusion, nUBE1L is a novel human E1 like gene highly expressed in adult testis, which plays key role in ubiquitin system, and accordingly influences spermatogenesis and male fertility. PMID: 15202508
    13. analysis of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme PMID: 16595681
    14. unusual type of regulation at the level of the E1 enzyme is likely to affect numerous cellular processes and may represent a strategy to coordinate multiple phenotypic changes upon differentiation by using E1 as a "master switch." PMID: 17060614
    15. Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s PMID: 17597759
    16. Large-scale mutation analysis in genes resulted in detection of 3 rare novel variants in exon 15 of UBE1 that segregate with X-linked infantile spinal muscular atrophy. PMID: 18179898
    17. high-level expression of UBE1 was seen inextranodal NK/T cell lymphoma, nasal type; there was no significant difference between UBE1 expression and patients' outcome PMID: 18661401

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Spinal muscular atrophy X-linked 2 (SMAX2)
  • 亞細胞定位:
    Cytoplasm. Mitochondrion. Nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
  • 蛋白家族:
    Ubiquitin-activating E1 family
  • 組織特異性:
    Detected in erythrocytes (at protein level). Ubiquitous.
  • 數據庫鏈接:

    HGNC: 12469

    OMIM: 301830

    KEGG: hsa:7317

    STRING: 9606.ENSP00000338413

    UniGene: Hs.533273



主站蜘蛛池模板: 成人性生交大片免费看视频app| 扒开双腿猛进入喷水高潮叫声| 日韩成人无码| 欧美尺码专线欧洲b1b1| 成人无遮羞视频在线观看| 亚洲中文字幕无码人在线| 国产voyeur精品偷窥222| 国产清纯美女爆白浆视频| 亚洲高清乱码午夜电影网制服| 精品无码成人网站久久久久久| 国产亚洲精品影视在线| 果冻传媒18禁免费视频 | 国产激情综合在线看| 午夜人成免费视频| 国产人妻一区二区三区四区五区六| 国产性天天综合网| 国产精品9999久久久久仙踪林| 伊人久久大香线蕉av一区| 人妻少妇邻居少妇好多水在线 | 亚洲精品成人福利网站| 亚洲精品图片区小说区| 国产人妻人伦精品1国产盗摄| 亚洲精品无码国产片| 欧美三级韩国三级日本三斤| 99久久精品日本一区二区免费| 欧美乱妇狂野欧美在线视频| 熟女人妻aⅴ一区二区三区麻豆| 国产成人av国语在线观看| 人妻丰满av无码中文字幕| 老熟妇性老熟妇性色| 久久精品国产99国产精品澳门| 无码免费毛片手机在线无卡顿| 亚洲国精产品一二二线| 日本丰满妇人成熟免费中文字幕| 欧美激情猛片xxxⅹ大3| 三级三级久久三级久久| 永久免费观看国产裸体美女 | 中文字字幕在线成人av电影| 14萝自慰专用网站| 亚洲18色成人网站www| 欧美人牲口杂交在线播放免费|