在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UBA1 Antibody

  • 中文名稱:
    UBA1兔多克隆抗體
  • 貨號:
    CSB-PA186952
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA186952(UBA1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hepg2, Jurkat, 231 and hela cell, Primary antibody: CSB-PA186952(UBA1 Antibody) at dilution 1/450 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    A1S9 antibody; A1S9 protein antibody; A1S9T and BN75 temperature sensitivity complementing antibody; A1S9T antibody; A1ST antibody; AMCX1 antibody; CFAP124 antibody; CTD-2522E6.1 antibody; GXP 1 antibody; GXP1 antibody; MGC4781 antibody; POC20 antibody; POC20 centriolar protein homolog antibody; Protein A1S9 antibody; SMAX2 antibody; Uba1 antibody; UBA1, ubiquitin-activating enzyme E1 homolog A antibody; UBA1_HUMAN antibody; UBA1A antibody; UBE 1 antibody; UBE 1X antibody; UBE1 antibody; UBE1X antibody; Ubiquitin activating enzyme E1 antibody; Ubiquitin-activating enzyme E1 antibody; Ubiquitin-like modifier-activating enzyme 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human UBA1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
  • 基因功能參考文獻:
    1. Polyubiquitination and proteasomal degradation of ezrin and CUGBP1 require Uba6, but not Uba1, and that Uba6 is involved in the control of ezrin localization and epithelial morphogenesis. These data suggest that distinctive substrate pools exist for Uba1 and Uba6 that reflect non-redundant biological roles for Uba6. PMID: 28134249
    2. Results from a study on gene expression variability markers in early-stage human embryos shows that UBA1 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    3. recent findings put UBA1 at the center of cellular homeostasis and neurodegeneration [review] PMID: 26432019
    4. A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes. PMID: 25207809
    5. Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation PMID: 25768649
    6. Ubiquitin-activating enzyme is necessary for 17beta-estradiol-induced breast cancer cell proliferation and migration. PMID: 25138535
    7. We expressed and purified the N-terminal domains of human E1 and determined their crystal structures, which contain inactive adenylation domain (IAD) and the first catalytic cysteine half-domain (FCCH) PMID: 25209502
    8. Diminished ubiquitylation phenotype observed in enteropathogenic Escherichia coli infected cells corresponds to a strong reduction in the abundance of both Ube1 and Uba6. PMID: 22999844
    9. Decrease in free ubiquitin levels under stress allows NEDD8 to be conjugated through Ube1. PMID: 22370482
    10. UBA1 knockdown impairs formation of ubiquitin conjugates at DNA double-strand breaks. PMID: 22456334
    11. Data show that largazole and ester/keto analogs inhibit ubiquitin E1 activation. PMID: 22279528
    12. In conclusion, nUBE1L is a novel human E1 like gene highly expressed in adult testis, which plays key role in ubiquitin system, and accordingly influences spermatogenesis and male fertility. PMID: 15202508
    13. analysis of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme PMID: 16595681
    14. unusual type of regulation at the level of the E1 enzyme is likely to affect numerous cellular processes and may represent a strategy to coordinate multiple phenotypic changes upon differentiation by using E1 as a "master switch." PMID: 17060614
    15. Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s PMID: 17597759
    16. Large-scale mutation analysis in genes resulted in detection of 3 rare novel variants in exon 15 of UBE1 that segregate with X-linked infantile spinal muscular atrophy. PMID: 18179898
    17. high-level expression of UBE1 was seen inextranodal NK/T cell lymphoma, nasal type; there was no significant difference between UBE1 expression and patients' outcome PMID: 18661401

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Spinal muscular atrophy X-linked 2 (SMAX2)
  • 亞細胞定位:
    Cytoplasm. Mitochondrion. Nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
  • 蛋白家族:
    Ubiquitin-activating E1 family
  • 組織特異性:
    Detected in erythrocytes (at protein level). Ubiquitous.
  • 數據庫鏈接:

    HGNC: 12469

    OMIM: 301830

    KEGG: hsa:7317

    STRING: 9606.ENSP00000338413

    UniGene: Hs.533273



主站蜘蛛池模板: 国产精品无码成人午夜电影| 国产在线观看无码免费视频| 欧美成人片在线观看| 国产又色又爽又黄的| 亚洲性视频免费视频网站| 亚洲 欧洲 日韩 综合色天使| 国产欧美日韩中文久久| 麻豆精品一区二区综合av| 人人爽人人爽人人片av| 亚洲欧洲国产综合aⅴ无码| 日韩免费无码专区精品观看| 久久综合噜噜激激的五月天| 国产肉体xxxx裸体137大胆| 国产精品乱子伦xxxx| 国产精品人妻久久久久| 日本中文字幕有码在线视频| 日本日本乱码伦视频在线观看| 做性久久久久久| 久久精品国产网红主播| 色播久久人人爽人人爽人人片av| 国产乱子伦精品免费女| 女上男下啪啪激烈高潮无遮盖| 欧美日本韩国亚洲| 国产av国片精品jk制服丝袜| 色综合久久久久久久久久| 在线亚洲高清揄拍自拍一品区| 永久中文字幕免费视频网站| 国产免费拔擦拔擦8x高清在线人| 欧美高清freexxxx性| 亚洲无人区午夜福利码高清完整版| 在线日韩av免费永久观看| 少妇特黄a一区二区三区| 女同亚洲一区二区无线码| 国产精品美女久久久久网站浪潮| 丰满的少妇xxxxx青青青| 乱人伦中文视频在线| 日日摸日日碰夜夜爽亚洲综合 | 国产精品久久久久久久久动漫| 美乳丰满人妻无码视频| 国产产品亚洲产品| 秋霞午夜成人久久电影网|