在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UBA1 Antibody, FITC conjugated

  • 中文名稱:
    UBA1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA00149C0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UBA1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    A1S9 antibody; A1S9 protein antibody; A1S9T and BN75 temperature sensitivity complementing antibody; A1S9T antibody; A1ST antibody; AMCX1 antibody; CFAP124 antibody; CTD-2522E6.1 antibody; GXP 1 antibody; GXP1 antibody; MGC4781 antibody; POC20 antibody; POC20 centriolar protein homolog antibody; Protein A1S9 antibody; SMAX2 antibody; Uba1 antibody; UBA1, ubiquitin-activating enzyme E1 homolog A antibody; UBA1_HUMAN antibody; UBA1A antibody; UBE 1 antibody; UBE 1X antibody; UBE1 antibody; UBE1X antibody; Ubiquitin activating enzyme E1 antibody; Ubiquitin-activating enzyme E1 antibody; Ubiquitin-like modifier-activating enzyme 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ubiquitin-like modifier-activating enzyme 1 protein (730-881AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
  • 基因功能參考文獻:
    1. Polyubiquitination and proteasomal degradation of ezrin and CUGBP1 require Uba6, but not Uba1, and that Uba6 is involved in the control of ezrin localization and epithelial morphogenesis. These data suggest that distinctive substrate pools exist for Uba1 and Uba6 that reflect non-redundant biological roles for Uba6. PMID: 28134249
    2. Results from a study on gene expression variability markers in early-stage human embryos shows that UBA1 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    3. recent findings put UBA1 at the center of cellular homeostasis and neurodegeneration [review] PMID: 26432019
    4. A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes. PMID: 25207809
    5. Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation PMID: 25768649
    6. Ubiquitin-activating enzyme is necessary for 17beta-estradiol-induced breast cancer cell proliferation and migration. PMID: 25138535
    7. We expressed and purified the N-terminal domains of human E1 and determined their crystal structures, which contain inactive adenylation domain (IAD) and the first catalytic cysteine half-domain (FCCH) PMID: 25209502
    8. Diminished ubiquitylation phenotype observed in enteropathogenic Escherichia coli infected cells corresponds to a strong reduction in the abundance of both Ube1 and Uba6. PMID: 22999844
    9. Decrease in free ubiquitin levels under stress allows NEDD8 to be conjugated through Ube1. PMID: 22370482
    10. UBA1 knockdown impairs formation of ubiquitin conjugates at DNA double-strand breaks. PMID: 22456334
    11. Data show that largazole and ester/keto analogs inhibit ubiquitin E1 activation. PMID: 22279528
    12. In conclusion, nUBE1L is a novel human E1 like gene highly expressed in adult testis, which plays key role in ubiquitin system, and accordingly influences spermatogenesis and male fertility. PMID: 15202508
    13. analysis of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme PMID: 16595681
    14. unusual type of regulation at the level of the E1 enzyme is likely to affect numerous cellular processes and may represent a strategy to coordinate multiple phenotypic changes upon differentiation by using E1 as a "master switch." PMID: 17060614
    15. Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s PMID: 17597759
    16. Large-scale mutation analysis in genes resulted in detection of 3 rare novel variants in exon 15 of UBE1 that segregate with X-linked infantile spinal muscular atrophy. PMID: 18179898
    17. high-level expression of UBE1 was seen inextranodal NK/T cell lymphoma, nasal type; there was no significant difference between UBE1 expression and patients' outcome PMID: 18661401

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Spinal muscular atrophy X-linked 2 (SMAX2)
  • 亞細胞定位:
    Cytoplasm. Mitochondrion. Nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
  • 蛋白家族:
    Ubiquitin-activating E1 family
  • 組織特異性:
    Detected in erythrocytes (at protein level). Ubiquitous.
  • 數據庫鏈接:

    HGNC: 12469

    OMIM: 301830

    KEGG: hsa:7317

    STRING: 9606.ENSP00000338413

    UniGene: Hs.533273



主站蜘蛛池模板: 丰满少妇大力进入| 狠狠做久久深爱婷婷| 在线播放偷拍一区精品| 97人妻天天摸天天爽天天| 国产人妻精品一区二区三区| 中文字幕av久久激情亚洲精品| 青椒国产97在线熟女| 国产无遮挡又黄又爽免费视频| 一区二区乱子伦在线播放| 亚洲系列一区中文字幕| 亚洲精品综合欧美一区二区三区 | 国产精品毛片在线完整版sab| 亚洲区日韩精品中文字幕| 色综合av综合无码综合网站| 成人亚洲欧美久久久久| 四虎www成人影院观看| 亚洲熟女一区二区三区| 日产幕无线码三区在线| 三级无码在钱av无码在钱| 国产成年无码v片在线| 国产精品久久久天天影视| 亚洲龙腾成小说人网| 99热精品毛片全部国产无缓冲| 一本大道久久久久精品嫩草| 亚洲有无码av在线播放| 久久人人97超碰a片精品| 一本一道av无码中文字幕﹣百度| 色欲麻豆国产福利精品| 欧美乱大交aaaa片if| 精品无码久久久久久久动漫| 亚洲日韩精品欧美一区二区 | 免费能直接看黄的视频| 老子影院午夜伦不卡无码 | 男女高潮又爽又黄又无遮挡| 色综合网天天综合色中文| 99久久国产综合精品五月天| 亚洲婷婷综合色高清在线| 丰满少妇被粗大的猛烈进出视频| 精品久久久久久无码人妻vr| 人人妻人人澡人人爽不卡视频 | 久久久久国色av免费看|