在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Tph1 Antibody, FITC conjugated

  • 中文名稱:
    Tph1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA024100HC01MO
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Mus musculus (Mouse) Tph1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    Tph1
  • 別名:
    Tph1 antibody; Tph antibody; Tryptophan 5-hydroxylase 1 antibody; EC 1.14.16.4 antibody; Tryptophan 5-monooxygenase 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse Tryptophan 5-hydroxylase 1 protein (1-447AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
  • 基因功能參考文獻:
    1. Both gut-specific Tph1 knockout mice and liver-specific Htr2a knockout mice are resistant to high fat diet-induced hepatic steatosis, without affecting systemic energy homeostasis. PMID: 30446669
    2. Data suggest that central melanocortin-4 receptor (MC4-R) and tryptophan hydroxylase (TPH) are involved in the efferent neuronal control of the kidneys. PMID: 27626491
    3. Prolactin-induced Tph1 expression. PMID: 26136513
    4. Tph1-deficient mice fed a high-fat diet (HFD) are protected from obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD) while exhibiting greater energy expenditure by brown adipose tissue. PMID: 25485911
    5. Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities. PMID: 23516593
    6. ZBP-89 directly binds to the Tph1 promoter, which is required for its basal and butyrate-inducible expression. PMID: 23395646
    7. TPH1 deficiency or inhibition reduces allergic airway inflammation. Platelet-derived 5-HT is pivotal in AAI and lack of 5-HT leads to impaired Th2 priming capacity of bone marrow dendritic cells. PMID: 23328530
    8. Data indicate that tryptophan hydroxylase (Tph)1-deficient mice, lacking non-neuronal serotonin, showed mild leukocytosis. PMID: 23243271
    9. Data show that Tph-1 (tryptophan hydroxylase-1) is a potent regulator of immunity. PMID: 23008335
    10. Parallel to Tph1 mRNA and protein induction, islet serotonin content increased to a peak level that was 200-fold higher than basal. Interestingly, only a subpopulation of the beta cells was serotonin-positive in vitro and in vivo. PMID: 20938637
    11. nonneuronal tph1 gene has a role in cardiac function with peripheral serotonin PMID: 14597720
    12. Review. TPH1 is expressed in the pineal gland and the enterochromaffin cells. Loss of TPH1 gene expression, and thus of peripheral 5-HT, leads to a cardiac dysfunction phenotype. PMID: 15146950
    13. estrogen receptor-beta is responsible for mediating estrogen regulated tryptophan hydroxylase-1 expression in the murine dorsal raphe nucleus PMID: 15820717
    14. TPH1 is expressed preferentially during late developmental brain stages. Low raphe nuclei 5-HT contents were seen during development in NZW & SWR mice with common functional polymorphisms in TPH1. TPH1 may influence behavior later in life. PMID: 16407550
    15. TPH1 is the predominant form expressed in pineal gland and with a molecular weight of 51 kDa. PMID: 16581041
    16. Tryptophan hydroxylase 1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxia-induced pulmonary vascular remodeling. PMID: 17130306
    17. Tph1 knockout mice used to show that serotonin plays a role in the pathogenesis of steatohepatitis. PMID: 17681180
    18. Cardiomyopathy is more severe in adult Tph1 knockout mice born to homozygous mothers than to heterozygous mothers. PMID: 18267982
    19. In a genetic model of serotonin deficiency (Tph1(-/-)) in mice, serotonin shown to be crucial for the growth of s.c. colon cancer allografts in vivo. PMID: 18593914
    20. substantially reduced peripheral 5-HT levels in Tph1/Tph2 double knockout, but not TPH2KO mice PMID: 18923670
    21. In mice no significant TPH1 expression was detected in the brain. PMID: 19181488

    顯示更多

    收起更多

  • 蛋白家族:
    Biopterin-dependent aromatic amino acid hydroxylase family
  • 數據庫鏈接:


主站蜘蛛池模板: 夜夜嗨av一区二区三区| 亚洲精品国产精品国自产观看| 黑鬼大战白妞高潮喷白浆| 老外和中国女人毛片免费视频| 久久久久女人精品毛片| 久久婷婷五月综合色和| 24小时日本在线www免费的| 亚洲暴爽av天天爽日日碰| 久久精品香蕉绿巨人登场| 最新在线精品国产福利| 最近最新中文字幕高清免费| 国内精品久久久久久久小说| 女被男啪到哭的视频网站 | 免费视频好湿好紧好大好爽| 亚洲人成图片小说网站| 免费观看黄网站在线播放| 日韩欧美一区二区三区免费观看 | 丰满女人又爽又紧又丰满| 免费又黄又裸乳的视频| 国产八十老太另类| 久久www免费人成看片入口| 亚洲无人区一区二区三区| 真实的国产乱xxxx在线| 久久久亚洲精品无码| 午夜理论片在线观看免费| 综合激情五月综合激情五月激情1 h漫全彩纯肉无码网站 | 欧美性猛少妇xxxxx免费| 波多野结衣办公室33分钟| 欧美三根一起进三p| 国产麻豆9l精品三级站| 国产精品激情欧美可乐视频| 久久99精品久久久久久清纯| 97国产色伦在色在线播放| 色综亚洲国产vv在线观看| 中文字幕亚洲日韩无线码| 久久综合久久88中字幕文| 国产精品人成电影在线观看| 成在线人av免费无码高潮喷水 | 无遮挡aaaaa大片免费看 | 国产精品国产免费无码专区不卡| 亚洲区欧美区综合区自拍区|