在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TUBG1 Antibody

  • 中文名稱:
    TUBG1兔多克隆抗體
  • 貨號:
    CSB-PA060026
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TUBG1
  • 別名:
    Gamma-1-tubulin antibody; Gamma-tubulin complex component 1 antibody; GCP-1 antibody; TBG1_HUMAN antibody; TUBG antibody; TUBG1 antibody; TUBGCP1 antibody; Tubulin gamma-1 chain antibody; Tubulin, gamma 1 antibody; Tubulin, gamma polypeptide antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human Tubulin γ.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
  • 基因功能參考文獻:
    1. CCT actively promotes the formation of conformationally different aggregates of gamma-tubulin, a non-amyloidogenic CCT client protein, which are mediated by specific CCT-gamma-tubulin interactions. PMID: 29339327
    2. that in the face of predominant gamma-tubulin-1 expression, the accumulation of gamma-tubulin-2 in mature neurons and neuroblastoma cells during oxidative stress may denote a prosurvival role of gamma-tubulin-2 in neurons PMID: 28119396
    3. All GCPs are incorporated into the helix via lateral interactions between their N-terminal domains, whereas the C-terminal domains mediate longitudinal interactions with gamma-tubulin. PMID: 27660388
    4. While binding to gamma-tubulin may help target APC to the site of microtubule nucleation complexes, additional C-terminal sequences of APC are required to stimulate and stabilize microtubule growth. PMID: 26556314
    5. Results show that CUL4A- and CUL4B-mediated polyubiquitination of gamma-tubulin for its degradation. PMID: 25542213
    6. In this study, the molecular basis of interaction between two lateral gamma-tubulin units within the gamma-tubulin ring complex were elucidated by making extensive use of molecular mechanics and molecular dynamics techniques. PMID: 25031076
    7. Gamma tubulin expression was associated with patients' age, astrocytoma grade, respectability, patient survival and performance. These factors may be important prognostic indicators for patients with astrocytomas. PMID: 24620973
    8. Recombinant gamma-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A in vitro. PMID: 23966160
    9. Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells. PMID: 22818914
    10. Our results reveal for the first time an increased expression of TUBG1 and TUBG2 in lung cancer PMID: 22806905
    11. overexpression of Cdk1 or BRCA1 greatly expands the gamma-tubulin coating of microtubules, suggesting that the microtubule-bound gamma-tubulin is involved in DNA damage response. PMID: 21951856
    12. in transformed as well as in non-transformed interphase mammalian cells gamma-tubulin is present not only in cytoplasm but also in nuclei and nucleoli where it can be translocated during mitosis PMID: 21465471
    13. These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with gamma-tubulin and underscore its critical role in the regulation of mitotic spindle assembly. PMID: 21795687
    14. The data presented here indicate that gamma-tubulin has a profound relationship with actin filament dynamics PMID: 21473851
    15. a direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome PMID: 20224777
    16. the 2.7-A crystal structure of human gamma-tubulin bound to GTP-gammaS (a non-hydrolysable GTP analogue) PMID: 15917813
    17. analysis of human ninein isoforms that are regulated by centrosomal targeting signals and bind to gamma-tubulin PMID: 17102634
    18. Data suggest that aberrant expression and interactions of betaIII-tubulin and gamma-tubulin may be linked to malignant changes in glial cells. PMID: 17406983
    19. GSK-3beta regulates the localization of gamma-tubulin ring complex, including GCP5, to the spindle poles, thereby controlling the formation of proper mitotic spindles PMID: 18316369
    20. The axial elastic modulus of tubulin diminishes as the length of the monomer increases. PMID: 18621829
    21. Increased expression of centrosomal TUBG in atypical ductal hyperplasia and carcinoma of the breast is reported. PMID: 19215229
    22. Stability of the small gamma-tubulin complex (gamma tubulin/GCP2/GCP3) requires HCA66, a protein of the centrosome and the nucleolus. PMID: 19299467
    23. Data suggest that sequential phosphorylation of Nedd1 by Cdk1 and Plk1 plays a role in targeting gamma tubulin ring complex to the centrosome by promoting the interaction of Nedd1 with the gammaTuRC component gamma-tubulin, during mitosis. PMID: 19509060
    24. Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components PMID: 19543530
    25. SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin. PMID: 19648910

    顯示更多

    收起更多

  • 相關疾病:
    Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族:
    Tubulin family
  • 數據庫鏈接:

    HGNC: 12417

    OMIM: 191135

    KEGG: hsa:7283

    STRING: 9606.ENSP00000251413

    UniGene: Hs.279669



主站蜘蛛池模板: 欧洲熟妇色xxxxx视频| 日韩a片无码毛片免费看| 中文天堂国产最新| 国产精品久久久久av| 国产精品综合一区二区三区| 隔壁人妻被水电工征服 | 国产精品无码午夜福利| 么公的好大好硬好深好爽视频| 一本一道vs无码中文字幕| 欧美成aⅴ人高清免费观看| 国产av无码专区亚洲版综合| 国产无套内射久久久国产| 精品亚洲国产成人a片app| 亚洲成aⅴ人最新无码| 中文无码久久精品| 人妻熟女一区二区aⅴ向井蓝| 亚州中文字幕无码中文字幕| 人人超碰人人超级碰国| 国产精品 视频一区 二区三区| 久久国产精品一国产精品| 久久久久久无码日韩欧美| 四虎成人精品永久在线视频| 乱中年女人伦| 亚洲综合色在线视频www| 熟女乱牛牛视频在线观看| 日韩电影一区二区三区| 亚洲国产午夜精品理论片在线播放| 忘忧草日本在线播放www| 欧洲精品卡一卡二卡三| 揄拍成人国产精品视频| 青草影院内射中出高潮| 亚洲男人成人性天堂网站| 日韩精品一区二区午夜成人版| 狠狠干狠狠爱| 亚洲国产成人无码av在线影院| 亚洲精品区午夜亚洲精品区| 又爽又黄又无遮挡的视频| 特级a欧美做爰片三人交| 亚洲国产制服丝袜高清在线| 性开放的女人aaa片| 肉大榛一进一出免费视频|