在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TUBB Antibody

  • 中文名稱:
    TUBB兔多克隆抗體
  • 貨號(hào):
    CSB-PA025318OJ01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: TUBB antibody at 6µg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: 293T whole cell lysate
      Lane 3: A549 whole cell lysate
      Lane 4: HepG2 whole cell lysate
      Lane 5: SH-SY5Y whole cell lysate
      Lane 6: Hela whole cell lysate
      Lane 7: Zebrafish lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 50 kDa
      Observed band size: 50 kDa
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) TUBB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Beta 4 tubulin antibody; Beta 5 tubulin antibody; beta Ib tubulin antibody; Beta1 tubulin antibody; Class I beta tubulin antibody; M40 antibody; MGC117247 antibody; MGC16435 antibody; OK/SW cl.56 antibody; OK/SWcl.56 antibody; TBB5_HUMAN antibody; TUBB 1 antibody; TUBB 2 antibody; TUBB 5 antibody; TUBB antibody; TUBB1 antibody; TUBB2 antibody; TUBB5 antibody; tubulin beta 1 chain antibody; Tubulin beta 2 chain antibody; tubulin beta 5 chain antibody; Tubulin beta chain antibody; Tubulin beta class I antibody; tubulin beta polypeptide antibody; Tubulin beta-5 chain antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Zebrafish
  • 免疫原:
    Peptide sequence from Human Tubulin beta chain protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.1mol/L NaCl, 15mmol/L NaN3, PH7.2
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能參考文獻(xiàn):
    1. human tumor cells can acquire spontaneous mutations in beta1-tubulin that cause resistance to paclitaxel PMID: 20103599
    2. Roles of tubulin beta 1,3 residues Ala428 and Thr429 in microtubule formation in vivo. PMID: 19074767
    3. TUBB exon 4 mutations and mismatch repair defects do not play a significant role in paclitaxel/cisplatin resistance PMID: 16095531
    4. Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. PMID: 26637975
    5. the dipole moments of each tubulin isotype may influence their functional characteristics within the cell, resulting in differences for MT assembly kinetics and stability PMID: 16941085
    6. Leucine point mutations viz. L215H, L217R, and L225M were reported for paclitaxel resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations in TUBB1 was explored using molecular docking, molecular dynamics simulation, binding energy estimation, free energy decomposition, principle component analysis and free energy landscape methods. PMID: 27233604
    7. Data suggest a looser binding of the ligand in tubulin mutants. PMID: 26081685
    8. Data show that tubulin phosphorylation and acetylation play important roles in the control of microtubule assembly and stability. PMID: 26165356
    9. Data suggest that, while lacking a stable structure, NFL-TBS.40-63 peptide (a peptide derived from light neurofilament protein) preferentially binds on a specific single site located near C-terminal end of beta-tubulin. PMID: 26016807
    10. Citrullination of TUBB is associated with neoplasms. PMID: 24099319
    11. mechanism of binding and stabilization of microtubules in mammalian cells can be effectively modeled in yeast and also having the advantage of lacking any beta-tubulin isotypes that can complicate interpretation of experiments in mammalian cells. PMID: 24161989
    12. Studies suggest that tubulin-interactive agents have the potential to play a significant role in the fight against cancer. PMID: 23818224
    13. results provide insight into the functional repertoire of the tubulin gene family, specifically implicating TUBB5 in embryonic neurogenesis and microcephaly PMID: 23246003
    14. TQ induced a concentration- and time-dependent degradation of alpha/beta tubulin in both cancer cell types. PMID: 21881916
    15. Allele frequencies between a group of 191 ITP patients & controls showed no direct aetiological role for SNP (R307H), but it was associated with immunomodulatory treatment failure. PMID: 23157319
    16. Data show that knockdown of S100P led to downregulation of thioredoxin 1 and beta-tubulin and upregulation of RhoGDIA, all potential therapeutic targets in cancer. PMID: 21327297
    17. This is the first cell-based evidence to support a beta-tubulin-binding site for peloruside A and laulimalide. PMID: 21653684
    18. Mutational analysis of the class I beta-tubulin gene in human breast cancer PMID: 12209587
    19. the influence of beta-tubulin mutations in paclitaxel resistance in advanced non-small cell lung cancer PMID: 12826311
    20. Review of studies comparing beta-tubulin mutations with antitubulin drug resistance. Throws doubts on earlier such correlation because of the existence of many pseudogenes for beta-tubulin. PMID: 15003198
    21. These data indicate that phosphorylation of tubulin by Cdk1 could be involved in the regulation of microtubule dynamics during mitosis. PMID: 16371510
    22. cDNA subtraction revealed increased expression of alpha3-tubulin in the taxol-resistant cell line. PMID: 16380805
    23. Nuclear matrix proteins such as mutant Pyst1 and nucleophosmin 1 were downregulated, whereas eIF6 and beta-tubulin were upregulated during cell differentiation in hepatocarcinoma cells. PMID: 17569113
    24. Results suggest that glutamate198 in beta-tubulin is a critical determinant for microtubule stability and Taxol resistance. PMID: 17869412
    25. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Cortical dysplasia, complex, with other brain malformations 6 (CDCBM6); Skin creases, congenital symmetric circumferential, 1 (CSCSC1)
  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Tubulin family
  • 組織特異性:
    Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20778

    OMIM: 156610

    KEGG: hsa:203068

    STRING: 9606.ENSP00000339001

    UniGene: Hs.636480



主站蜘蛛池模板: 国产乱视频在线观看| 闺蜜张开腿让我爽了一夜| 成人国产亚洲精品a区天堂| 久久国产精品成人影院| 亚洲国产天堂久久久久久| 日本三级带日本三级带黄| 97人妻天天摸天天爽天天| 高清无码午夜福利视频| 午夜福利一区二区三区高清视频| 国内野外强奷在线视频| 4399理论片午午伦夜理片 | 一边摸一边做爽的视频17国产| 国产成人无码免费视频97| 亚洲国产成人爱av网站| 四虎永久地址www成人| 国产剧情麻豆女教师在线观看| 成人av久久一区二区三区| 亚洲精品av无码喷奶水网站| 国产毛片欧美毛片久久久| 久久97国产超碰青草| 天天摸夜夜摸夜夜狠狠添| 永久免费不卡在线观看黄网站| 欧美多人片高潮野外做片黑人| 国产公妇仑乱在线观看| 狂野欧美激情性xxxx按摩| 一本大道伊人av久久乱码| 色情无码一区二区三区| 国产日韩在线视看高清视频手机| 草草浮力地址线路①屁屁影院 | 97久久久久人妻精品区一| av不卡国产在线观看| 亚洲小说春色综合另类| 国产亚洲精品久久久久久老妇小说| 国产精品亚洲lv粉色| 无码中文人妻在线三区| 精品无码乱码av| 中文人妻熟女乱又乱精品| 久久婷婷五月综合97色直播| 乱子伦国产对白在线播放| 伴郎粗大的内捧猛烈进出视频观看| 久久久www成人免费精品|