在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TUBB Antibody

  • 中文名稱:
    TUBB兔多克隆抗體
  • 貨號(hào):
    CSB-PA025318OJ01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: TUBB antibody at 6µg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: 293T whole cell lysate
      Lane 3: A549 whole cell lysate
      Lane 4: HepG2 whole cell lysate
      Lane 5: SH-SY5Y whole cell lysate
      Lane 6: Hela whole cell lysate
      Lane 7: Zebrafish lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 50 kDa
      Observed band size: 50 kDa
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) TUBB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Beta 4 tubulin antibody; Beta 5 tubulin antibody; beta Ib tubulin antibody; Beta1 tubulin antibody; Class I beta tubulin antibody; M40 antibody; MGC117247 antibody; MGC16435 antibody; OK/SW cl.56 antibody; OK/SWcl.56 antibody; TBB5_HUMAN antibody; TUBB 1 antibody; TUBB 2 antibody; TUBB 5 antibody; TUBB antibody; TUBB1 antibody; TUBB2 antibody; TUBB5 antibody; tubulin beta 1 chain antibody; Tubulin beta 2 chain antibody; tubulin beta 5 chain antibody; Tubulin beta chain antibody; Tubulin beta class I antibody; tubulin beta polypeptide antibody; Tubulin beta-5 chain antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Zebrafish
  • 免疫原:
    Peptide sequence from Human Tubulin beta chain protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.1mol/L NaCl, 15mmol/L NaN3, PH7.2
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能參考文獻(xiàn):
    1. human tumor cells can acquire spontaneous mutations in beta1-tubulin that cause resistance to paclitaxel PMID: 20103599
    2. Roles of tubulin beta 1,3 residues Ala428 and Thr429 in microtubule formation in vivo. PMID: 19074767
    3. TUBB exon 4 mutations and mismatch repair defects do not play a significant role in paclitaxel/cisplatin resistance PMID: 16095531
    4. Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. PMID: 26637975
    5. the dipole moments of each tubulin isotype may influence their functional characteristics within the cell, resulting in differences for MT assembly kinetics and stability PMID: 16941085
    6. Leucine point mutations viz. L215H, L217R, and L225M were reported for paclitaxel resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations in TUBB1 was explored using molecular docking, molecular dynamics simulation, binding energy estimation, free energy decomposition, principle component analysis and free energy landscape methods. PMID: 27233604
    7. Data suggest a looser binding of the ligand in tubulin mutants. PMID: 26081685
    8. Data show that tubulin phosphorylation and acetylation play important roles in the control of microtubule assembly and stability. PMID: 26165356
    9. Data suggest that, while lacking a stable structure, NFL-TBS.40-63 peptide (a peptide derived from light neurofilament protein) preferentially binds on a specific single site located near C-terminal end of beta-tubulin. PMID: 26016807
    10. Citrullination of TUBB is associated with neoplasms. PMID: 24099319
    11. mechanism of binding and stabilization of microtubules in mammalian cells can be effectively modeled in yeast and also having the advantage of lacking any beta-tubulin isotypes that can complicate interpretation of experiments in mammalian cells. PMID: 24161989
    12. Studies suggest that tubulin-interactive agents have the potential to play a significant role in the fight against cancer. PMID: 23818224
    13. results provide insight into the functional repertoire of the tubulin gene family, specifically implicating TUBB5 in embryonic neurogenesis and microcephaly PMID: 23246003
    14. TQ induced a concentration- and time-dependent degradation of alpha/beta tubulin in both cancer cell types. PMID: 21881916
    15. Allele frequencies between a group of 191 ITP patients & controls showed no direct aetiological role for SNP (R307H), but it was associated with immunomodulatory treatment failure. PMID: 23157319
    16. Data show that knockdown of S100P led to downregulation of thioredoxin 1 and beta-tubulin and upregulation of RhoGDIA, all potential therapeutic targets in cancer. PMID: 21327297
    17. This is the first cell-based evidence to support a beta-tubulin-binding site for peloruside A and laulimalide. PMID: 21653684
    18. Mutational analysis of the class I beta-tubulin gene in human breast cancer PMID: 12209587
    19. the influence of beta-tubulin mutations in paclitaxel resistance in advanced non-small cell lung cancer PMID: 12826311
    20. Review of studies comparing beta-tubulin mutations with antitubulin drug resistance. Throws doubts on earlier such correlation because of the existence of many pseudogenes for beta-tubulin. PMID: 15003198
    21. These data indicate that phosphorylation of tubulin by Cdk1 could be involved in the regulation of microtubule dynamics during mitosis. PMID: 16371510
    22. cDNA subtraction revealed increased expression of alpha3-tubulin in the taxol-resistant cell line. PMID: 16380805
    23. Nuclear matrix proteins such as mutant Pyst1 and nucleophosmin 1 were downregulated, whereas eIF6 and beta-tubulin were upregulated during cell differentiation in hepatocarcinoma cells. PMID: 17569113
    24. Results suggest that glutamate198 in beta-tubulin is a critical determinant for microtubule stability and Taxol resistance. PMID: 17869412
    25. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Cortical dysplasia, complex, with other brain malformations 6 (CDCBM6); Skin creases, congenital symmetric circumferential, 1 (CSCSC1)
  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Tubulin family
  • 組織特異性:
    Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20778

    OMIM: 156610

    KEGG: hsa:203068

    STRING: 9606.ENSP00000339001

    UniGene: Hs.636480



主站蜘蛛池模板: 大伊香蕉在线精品视频75| 99国产精品人妻噜啊噜| 国产人妻人伦精品1国产| 成人做爰视频www网站小优视频| 久久久久无码精品国产人妻无码| 日韩免费无码人妻波多野| 中文在线天堂а√在线| 国产成人精品aa毛片| 亚洲国产长腿丝袜av天堂| 欧美日韩国产免费一区二区三区| 青草久久人人97超碰| 国产亚洲另类无码专区| 茄子视频国产在线观看| 在线播放五十路熟妇| 欧美最猛黑人xxxx黑人猛交| 青青青国产在线观看资源| 无码精品人妻一区二区三区av| 99久久亚洲精品日本无码| 超碰国产精品久久国产精品99| 人人妻人人爽人人做夜欢视频 | 国产精品久久久久久妇女| 夜夜欢性恔免费视频| 免费网站内射红桃视频| 久久久久久久性潮| 亚洲精品无码久久久久久久| 少妇夜夜春夜夜爽试看视频| 一区二区三区四区在线 | 欧洲| 男人猛吃奶女人爽视频| 亚洲欧美一区二区三区在线| 亚洲国产午夜精品理论片妓女| 色欲香天天综合网站| 一本大道伊人av久久乱码| 狼人大香伊蕉国产www亚洲| 国产激情综合在线看| 与子敌伦刺激对白播放| 欧洲熟妇色 欧美| 亚洲国产精品13p| 99久久久国产精品消防器材| 国产精品一区二区无线| 亚洲精品久久久蜜桃| 国产成人无码午夜福利在线直播|