在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TTLL5 Antibody, Biotin conjugated

  • 中文名稱:
    TTLL5兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA715737LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TTLL5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    KIAA0998 antibody; SRC1 and TIF2-associated modulatory protein antibody; STAMP antibody; TTLL5 antibody; TTLL5_HUMAN antibody; Tubulin polyglutamylase TTLL5 antibody; Tubulin--tyrosine ligase-like protein 5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tubulin polyglutamylase TTLL5 protein (1-269AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail. Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules. Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction.
  • 基因功能參考文獻:
    1. in a study of 3 family members from 2 generations, identified in a previously misdiagnosed incomplete congenital stationary night blindness (icCSNB) case a splice-site mutation in intron 3 of TTLL5 (c.182-3_182-1delinsAA); reinvestigation of the clinical data corrected the diagnosis to cone dystrophy PMID: 28356705
    2. 5 homozygous variants [p.(Asp594fs), p.(Gln117*), p.(Met712fs), p.(Ile756Phe) and p.(Glu543Lys)] in TTLL5, in 8 patients from 6 families were identified. 2 male patients carrying truncating TTLL5 variants also displayed a reduction in sperm motility and infertility, whereas those carrying missense changes were fertile. TTLL has multiple viable isoforms, being highly expressed in retina, testis and spermatozoon flagellum. PMID: 28173158
    3. this study has performed exome sequencing in 28 individuals with a similar disease phenotype and subsequently used a casecontrol approach to identify mutations in TTLL5 as a cause of recessive retinal dystrophy. PMID: 24791901
    4. This study indicates that a physiological function of STAMP in several settings is to modify cell growth rates in a manner that can be independent of steroid hormones. PMID: 20374646
    5. STAMP is an important new, downstream component of GR action in both gene activation and gene repression. PMID: 17116691

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Cone-rod dystrophy 19 (CORD19)
  • 亞細胞定位:
    Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm.
  • 蛋白家族:
    Tubulin--tyrosine ligase family
  • 組織特異性:
    Expressed in the retina, found in the rod and cone photoreceptors (at protein level). Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues.
  • 數據庫鏈接:

    HGNC: 19963

    OMIM: 612268

    KEGG: hsa:23093

    STRING: 9606.ENSP00000298832

    UniGene: Hs.709609



主站蜘蛛池模板: 日韩毛片在线视频x| 国产成人无码激情视频| 高清无码爆乳潮喷在线观看| 99国产欧美另娄久久久精品| 波多野结衣一区二区三区av高清| 久久久性色精品国产免费观看| 伊人大香人妻在线播放| 久久人午夜亚洲精品无码区| 在线观看免费视频网站a站| 亚洲一区二区三区偷拍女厕| 成 人影片 免费观看| а√天堂www在线а√天堂视频| 国产精品久久久久久久伊一| 亚洲成熟丰满熟妇高潮xxxxx| 亚洲最大无码中文字幕| 99精品热这里只有精品| 亚洲男人的天堂一区二区| 一本加勒比波多野结衣| 寂寞少妇做spa按摩无码| 亚洲美女精品免费视频| 成人黄网站高清免费视频| 亚洲毛片αv无线播放一区| 亚洲熟女乱色综合亚洲图片| 国产人妻高清国产拍精品| 久久国产午夜精品理论片34页| 在线观看国产亚洲视频免费| 亚洲成av人片一区二区| 一本久久综合亚洲鲁鲁五月天| 欧美人与禽zozzo性伦交| 色婷婷av一区二区三区浪潮| 99久久精品无码一区二区三区| 中文字幕日韩精品无码内射| 免费毛片手机在线播放| 国产在线精品99一区不卡| 天天摸天天碰天天添| 日韩欧美中文字幕在线三区| 在线观看免费人成视频网| 精品国产自在现线看久久| 少妇av一区二区三区无码| 2018天天躁夜夜躁狠狠躁| 亚洲国产精品无码中文lv|