在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRIP6 Antibody

  • 中文名稱:
    TRIP6兔多克隆抗體
  • 貨號:
    CSB-PA024528GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    MGC10556 antibody; MGC10558 antibody; MGC29959 antibody; MGC3837 antibody; MGC4423 antibody; OIP-1 antibody; OIP1 antibody; OPA interacting protein 1 antibody; OPA-interacting protein 1 antibody; Thyroid hormone receptor interactor 6 antibody; Thyroid receptor interacting protein 6 antibody; Thyroid receptor-interacting protein 6 antibody; TR-interacting protein 6 antibody; TRIP-6 antibody; Trip6 antibody; TRIP6_HUMAN antibody; TRIP6i2 antibody; ZRP 1 antibody; ZRP-1 antibody; Zyxin-related protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TRIP6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
  • 基因功能參考文獻:
    1. Taken together, these findings showed that TRIP6 plays an important role in promoting HCC cells proliferation and may serve as a novel prognostic biomarker and therapeutic target in HCC. PMID: 29080747
    2. TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma PMID: 26298725
    3. the Trip6-GRIP1-myosin VI interaction and its regulation on F-actin network play a significant role in dendritic morphogenesis PMID: 25673849
    4. TRIP6 acts, in contrast to Zyxin, as an oncogene that partially accounts for the autonomous migratory, invasive and proliferative properties of Ewing's sarcoma cells. PMID: 24033704
    5. TRIP6 overexpression promotes migration, invasion, and clonogenicity of Ewing's sarcoma cells PMID: 24033704
    6. TRIP6 is involved in the regulation of nasopharyngeal carcinoma cell motility, and phosphorylation of tyrosine 55 residue plays an important regulatory role for this event PMID: 23576104
    7. TRIP6 also promotes serum-induced reduction of nuclear p27(KIP1) expression levels. PMID: 23339869
    8. High TRIP6 expression is associated with malignant pleural mesothelioma. PMID: 23313295
    9. TRIP6 is engaged in cell proliferation, differentiation, transcription regulation and contributes to genome stability. [Review] PMID: 22054418
    10. TRIP6 is a nucleocytoplasmatic shuttle protein essential for the coordination of focal adhesion dynamics and transcriptional responses in lysophosphosphatidic (LPA) and NF-kappaB signaling. PMID: 22054418
    11. TRIP6 is an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. (Review) PMID: 21689746
    12. TRIP6 promotes Fas-mediated cell migration in apoptosis-resistant glioma cells. This effect is regulated via the Src-dependent phosphorylation of TRIP6 at Tyr-55. PMID: 20876301
    13. the OIP-1 c-peptide is the functional domain of OIP-1 PMID: 11771657
    14. TRIP6 functions at a point of convergence between the activated LPA(2) receptor and downstream signals involved in cell adhesion and migration PMID: 14688263
    15. ZRP-1 has a role in endoglin regulation of cytoskeletal organization PMID: 15148318
    16. The data establish a physical and functional association between TRIP6 and RIP2, and suggest that RIP2's involvement in multiple NF-kappaB and ERK activation pathways is mediated through TRIP6. PMID: 15657077
    17. Binding of LPP and TRIP6 to Scrib links Scrib to a communication pathway between cell-cell contacts and the nucleus, and implicates these zyxin family members in Scrib-associated functions. PMID: 16137684
    18. The TRIP6 knock-down led to an increased number of longer stress fibers and to the induction of locomotive phenotype in carcinoma cells. PMID: 16240724
    19. AMPK phosphorylated TRIP6 in vitro at the N-terminus and the transcriptional co-activator properties of TRIP6 were enhanced by AMPK action. PMID: 16624523
    20. ZRP-1 plays a crucial role in coupling the cell-matrix/cell-cell-contact signals with Rho GTPase-mediated actin remodeling by localizing at cell-matrix and cell-cell contact sites. PMID: 17652164
    21. OIP-1 inhibits measles virus nucleocapsid protein induced pagetic osteoclast formation/activity through suppression of RANK signaling PMID: 18348201
    22. TRIP6 overexpression in colon tumors suggests its critical role in cancer progression. PMID: 19017743
    23. IL-12 stimulates the OIP-1 gene expression through STAT-3 activation in CD4+ T cells. PMID: 19259951
    24. Analysis of the subcellular distribution of ZRP-1 demonstrated that in the absence of endoglin, ZRP-1 mainly localizes to focal adhesion sites, whereas in the presence of endoglin ZRP-1 is found along actin stress fibers. PMID: 15148318

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm.
  • 蛋白家族:
    Zyxin/ajuba family
  • 組織特異性:
    Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.
  • 數據庫鏈接:

    HGNC: 12311

    OMIM: 602933

    KEGG: hsa:7205

    STRING: 9606.ENSP00000200457

    UniGene: Hs.534360



主站蜘蛛池模板: 国产成人无码免费看片软件| 国产重口老太和小伙| 中文成人无字幕乱码精品区| 国产产区一二三产区区别在线 | 亚洲乱妇老熟女爽到高潮的片| 亚洲中文字幕无码一久久区 | 亚洲爆乳成av人在线蜜芽| 羞国产在线拍揄自揄视频| 国产精品久久久久久久久电影网 | 无码人妻h动漫中文字幕| 久久亚洲a片com人成| 四虎亚洲精品成人a在线观看| 精品成人毛片一区二区| 漂亮人妻被中出中文字幕| 亚洲国产精品久久久久爰色欲| 曰本极品少妇videossexhd| 亚洲国产精品无码久久| 国产免费又色又爽粗视频| 国产成人精品综合在线观看| 国产精品无码av在线一区| 国产做a爰片久久毛片a片美国| 无码人妻少妇色欲av一区二区| 好爽…又高潮了免费毛片| 最近中文字幕免费mv在线| 亚洲人成网站18禁止大app| 真人与拘做受免费视频| 国产乱人伦偷精品视频免观看| 国产精品国产三级国av在线观看 | 亚洲乱亚洲乱妇24p| 色惰日本视频网站www| 熟妇高潮精品一区二区三区| 亚洲人成在线观看| 亚洲国产av天码精品果冻传媒| 久久天天躁狠狠躁夜夜爽| 无码一区二区| 无码国模国产在线观看免费| 亚洲成av人片在线观看一区二区三区| 67194熟妇在线观看线路1| 亚洲午夜性猛春交xxxx| 伊人成伊人成综合网222| 人妻少妇精品一区二区三区|