在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TRIM35 Antibody

TRIM35 Antibody

  • 中文名稱：
    TRIM35兔多克隆抗體
  • 貨號：
    CSB-PA192313
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA192313(TRIM35 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A375 cells, human fetal muscle tissue, Primary antibody: CSB-PA192313(TRIM35 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TRIM35
  • 別名：
    0710005M05Rik antibody; A430106H13Rik antibody; AW046487 antibody; Hemopoietic lineage switch protein 5 antibody; HLS5 antibody; KIAA1098 antibody; Macrophage derived apoptosis inducing RBCC protein antibody; MAIR antibody; MGC17233 antibody; mKIAA1098 antibody; NC8 antibody; Protein MAIR antibody; Protein Nc8 antibody; TRI35_HUMAN antibody; TRIM35 antibody; Tripartite motif containing 35 antibody; Tripartite motif containing protein 35 antibody; Tripartite motif-containing protein 35 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human TRIM35
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via DDX58/RIG-I signaling pathway. Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth.
  • 基因功能參考文獻：
    1. Authors subsequently investigated whether miR-4417 and TRIM35 regulate HCC cell proliferation and apoptosis through PKM2 Y105 phosphorylation, and the results supported our speculation that miR-4417 targets TRIM35 and regulates the Y105 phosphorylation of PKM2 to promote hepatocarcinogenesis. PMID: 28394882
    2. Data suggest that pyruvate kinase isoform M2 (PKM2)/tripartite motif-containing 35 (TRIM35) expression could be a biomarker for the prognosis of hepatocellular carcinoma (HCC) and target for cancer therapy. PMID: 25576919
    3. TRIM35 regulates the Warburg effect and tumorigenicity through interaction with PKM2 in hepatocellular carcinoma. PMID: 25263439
    4. gene located on chromosome 8p21, a region implicated in leukemias and solid tumors; enforced expression inhibited cell growth, clonogenicity, and tumorigenicity; conceivable HLS5 is one of the tumor suppressor genes thought to reside at the 8p21 locus PMID: 14662771
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TRIM/RBCC family
  • 數據庫鏈接：

    HGNC: 16285

    OMIM: 617007

    KEGG: hsa:23087

    STRING: 9606.ENSP00000301924

    UniGene: Hs.104223



主站蜘蛛池模板： 国产喷水1区2区3区咪咪爱av| 色avav色av爱avav亚洲色拍| 无码ol丝袜高跟秘书在线观看| 无码av中文一区二区三区| 国产成人综合日韩精品无码不卡| 亚洲精品无码中文久久字幕| 亚洲精品鲁一鲁一区二区三区| 各种少妇正面bbw撒尿| 西西人体www大胆高清| 少妇午夜啪爽嗷嗷叫视频| 青青草国产久久精品| 亚洲欧洲日产国码无码网站 | 亚洲成本人无码薄码区| 伊人久久精品亚洲午夜| 国产偷v国产偷v亚洲高清| 搡老熟女老女人一区二区 | 亚洲欧洲日韩国内高清| 色一情一乱一乱一区99av| 老熟女老太婆爽| 综合亚洲另类欧美久久成人精品| 97免费人妻无码视频| 国产精品老熟女露脸视频| 亚洲图片校园另激情类小说| 国产女人乱子对白av片 | 国产午夜成人久久无码一区二区| 免费特级毛片| 久久精品国产99久久香蕉| 激情97综合亚洲色婷婷五 | 亚洲丁香五月激情综合| 亚洲欧美日韩综合av| 成人午夜福利视频镇东影视| 国产亚洲成av片在线观看| 色九月亚洲综合网| 国产免费一区二区三区不卡| 久久久久久无码午夜精品直播| 亚洲精品美女久久7777777| 四虎影视在线影院在线观看| 天天综合网久久综合免费人成| 就去干成人网| 免费体验区试看120秒| 亚洲成色最大综合在线 |