在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TRIM16 Antibody

TRIM16 Antibody

  • 中文名稱：
    TRIM16兔多克隆抗體
  • 貨號：
    CSB-PA006670
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    TRIM16
  • 別名：
    EBBP antibody; Estrogen responsive B box protein antibody; Estrogen-responsive B box protein antibody; TRI16_HUMAN antibody; TRIM 16 antibody; TRIM16 antibody; Tripartite motif containing 16 antibody; Tripartite motif containing protein 16 antibody; Tripartite motif-containing protein 16 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human TRIM16.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
  • 基因功能參考文獻：
    1. High TRIM16 expression is associated with drug resistance in Non-Small Cell Lung Cancer. PMID: 29295721
    2. TRIM16 inhibits the migration and invasion via suppressing the Sonic hedgehog signaling pathway in ovarian cancer cells. PMID: 27737724
    3. The cooperation between TRIM16 and Galectin-3 in targeting and activation of selective autophagy protects cells from lysosomal damage and Mycobacterium tuberculosis invasion. PMID: 27693506
    4. TRIM16 expression is decreased in prostate cancer tissues and overexpression of TRIM16 inhibits cell migration, invasion and the EMT process in vitro in prostate cancer through the transcription factor Snail. PMID: 27748839
    5. Results found that the expression of TRIM16 was significantly downregulated in hepatocellular carcinoma cell (HCC) lesions and define TRIM16 as an inhibitor of epithelial-mesenchymal transition and metastasis in HCC. PMID: 26892350
    6. TRIM16 directly regulated the degradation of Gli1 protein via the ubiquitinproteasome pathway. TRIM16 expression was low in breast cancer. It negatively correlated with metastasis and suppressed stem-cell properties in breast cancer cells. PMID: 26718507
    7. Data suggest that TRIM16 and TDP43 are both good prognosis indicators; data shows that TRIM16 inhibits cancer cell viability by a novel mechanism involving interaction and stabilisation of TDP43 with consequent effects on E2F1 and pRb proteins. PMID: 26902425
    8. Expression of SDMGC and TRIM16 was upregulated in the distant metastasis tissues PMID: 25866896
    9. Chromatin immunoprecipitation assays revealed TRIM16 directly bound the IFNbeta1 gene promoter. Low level TRIM16 expression in 91 melanoma patient samples, strongly correlated with lymph node metastasis, and, predicted poor patient prognosis. PMID: 25333256
    10. results suggest that TRIM16 is a potential pharmacologic target for the treatment of NSCLC and promotion TRIM16 expression might represent a novel strategy to NSCLC metastasis PMID: 25843803
    11. TRIM16 can promote apoptosis by directly modulating caspase-2 activity in cancer cells. PMID: 23404198
    12. data suggest that TRIM16 acts as a novel regulator of both neuroblastoma G 1/S progression and cell differentiation PMID: 23422002
    13. via its unique structure, TRIM16 possesses both heterodimerization function with other TRIM proteins and also has E3 ubiquitin ligase activity. PMID: 22629402
    14. TRIM16 acts as a tumour suppressor, affecting neuritic differentiation, cell migration and replication through interactions with cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells. PMID: 20729920
    15. role in regulating keratinocyte differentiation PMID: 11919186
    16. These results provide evidence for a role of EBBP in innate immunity by enhancing the alternative secretion pathway of IL-1beta. PMID: 16575408
    17. EBBP increased betaRARE-transactivating function through its coiled-coil domain PMID: 16636064
    18. The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation. PMID: 19147277

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    TRIM/RBCC family
  • 組織特異性：
    Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17241

    OMIM: 609505

    KEGG: hsa:10626

    STRING: 9606.ENSP00000338989

    UniGene: Hs.123534



主站蜘蛛池模板： 超caopor在线公开视频| 免费中文字幕日韩欧美| 无码免费无线观看在线视频| 久久人人爽人人爽人人片av| 狼友av永久网站免费观看孕交| 日本少妇寂寞少妇aaa| 妺妺窝人体色www在线观看| 色妺妺在线视频| 天堂av男人在线播放| 97久久国产露脸精品国产| 不卡av中文字幕手机看 | 久久996re热这里有精品| 久久无码人妻一区二区三区午夜| 强行糟蹋人妻hd中文字| 亚洲 精品 制服 校园 无码| 日产精品卡1卡2卡三卡在线| 亚洲国产欧美中文丝袜日韩| 日本人妻巨大乳挤奶水| 9l国产精品久久久久尤物| 狠狠cao2020高清视频| 无码中文字幕免费一区二区三区| aⅴ亚洲 日韩 色 图网站 播放 | 国产两女互慰高潮视频在线观看| 国产suv精品一区二区33| 日本亚洲色大成网站www| 51被公侵犯玩弄漂亮人妻| 久久亚洲色www成人不卡| 久久久噜噜噜www成人网| 日本添下边视频全过程| 香蕉免费一区二区三区在| 成年女人永久免费看片| 亚洲乱妇亚洲乱妇xinglu| 老太脱裤让老头玩ⅹxxxx | 18禁无遮挡无码网站免费| 99爱在线精品视频免费观看| 欧美日本免费一区二区三区| 国产亚洲精品久久久久久无几年桃| 国内精品伊人久久久久av| 人人澡人人妻人人爽人人蜜桃麻豆| 免费观看成人欧美www色| 十八禁裸体www网站免费观看|