在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRIM16 Antibody, HRP conjugated

  • 中文名稱:
    TRIM16兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA024453LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TRIM16 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TRIM16
  • 別名:
    EBBP antibody; Estrogen responsive B box protein antibody; Estrogen-responsive B box protein antibody; TRI16_HUMAN antibody; TRIM 16 antibody; TRIM16 antibody; Tripartite motif containing 16 antibody; Tripartite motif containing protein 16 antibody; Tripartite motif-containing protein 16 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tripartite motif-containing protein 16 protein (1-300AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
  • 基因功能參考文獻:
    1. High TRIM16 expression is associated with drug resistance in Non-Small Cell Lung Cancer. PMID: 29295721
    2. TRIM16 inhibits the migration and invasion via suppressing the Sonic hedgehog signaling pathway in ovarian cancer cells. PMID: 27737724
    3. The cooperation between TRIM16 and Galectin-3 in targeting and activation of selective autophagy protects cells from lysosomal damage and Mycobacterium tuberculosis invasion. PMID: 27693506
    4. TRIM16 expression is decreased in prostate cancer tissues and overexpression of TRIM16 inhibits cell migration, invasion and the EMT process in vitro in prostate cancer through the transcription factor Snail. PMID: 27748839
    5. Results found that the expression of TRIM16 was significantly downregulated in hepatocellular carcinoma cell (HCC) lesions and define TRIM16 as an inhibitor of epithelial-mesenchymal transition and metastasis in HCC. PMID: 26892350
    6. TRIM16 directly regulated the degradation of Gli1 protein via the ubiquitinproteasome pathway. TRIM16 expression was low in breast cancer. It negatively correlated with metastasis and suppressed stem-cell properties in breast cancer cells. PMID: 26718507
    7. Data suggest that TRIM16 and TDP43 are both good prognosis indicators; data shows that TRIM16 inhibits cancer cell viability by a novel mechanism involving interaction and stabilisation of TDP43 with consequent effects on E2F1 and pRb proteins. PMID: 26902425
    8. Expression of SDMGC and TRIM16 was upregulated in the distant metastasis tissues PMID: 25866896
    9. Chromatin immunoprecipitation assays revealed TRIM16 directly bound the IFNbeta1 gene promoter. Low level TRIM16 expression in 91 melanoma patient samples, strongly correlated with lymph node metastasis, and, predicted poor patient prognosis. PMID: 25333256
    10. results suggest that TRIM16 is a potential pharmacologic target for the treatment of NSCLC and promotion TRIM16 expression might represent a novel strategy to NSCLC metastasis PMID: 25843803
    11. TRIM16 can promote apoptosis by directly modulating caspase-2 activity in cancer cells. PMID: 23404198
    12. data suggest that TRIM16 acts as a novel regulator of both neuroblastoma G 1/S progression and cell differentiation PMID: 23422002
    13. via its unique structure, TRIM16 possesses both heterodimerization function with other TRIM proteins and also has E3 ubiquitin ligase activity. PMID: 22629402
    14. TRIM16 acts as a tumour suppressor, affecting neuritic differentiation, cell migration and replication through interactions with cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells. PMID: 20729920
    15. role in regulating keratinocyte differentiation PMID: 11919186
    16. These results provide evidence for a role of EBBP in innate immunity by enhancing the alternative secretion pathway of IL-1beta. PMID: 16575408
    17. EBBP increased betaRARE-transactivating function through its coiled-coil domain PMID: 16636064
    18. The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation. PMID: 19147277

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    TRIM/RBCC family
  • 組織特異性:
    Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.
  • 數據庫鏈接:

    HGNC: 17241

    OMIM: 609505

    KEGG: hsa:10626

    STRING: 9606.ENSP00000338989

    UniGene: Hs.123534



主站蜘蛛池模板: 亚洲妇女行蜜桃av网网站| 亚洲色无码中文字幕yy51999| 亚洲另类色区欧美日韩图片| 国产精品久久久福利| 高潮毛片又色又爽免费| 亚洲va久久久噜噜噜久久4399| 亚洲 欧美 日韩 综合aⅴ电影| 国色天香成人一区二区| 亚洲美女被黑人巨大在线播放| 国产伦理一区二区| 天天噜噜噜在线视频| 亚洲aⅴ无码国精品中文字慕| 久久国产欧美成人av| 日日av拍夜夜添久久免费| 无码专区人妻系列日韩精品少妇| 久久/这里只精品热在线获取| 日本高清在线www3344| 国产乱子伦精品无码码专区| 人妻熟妇乱又伦精品视频中文字幕| 中文字幕av伊人av无码av| 色视频无码专区在线观看| 久久青青草原精品国产| 亚洲va中文字幕| 国产精品进线69影院| 精品国产免费人成电影在线看| 日日夜夜撸啊撸| 无码高潮少妇毛多水多水免费| 久久亚洲国产精品影院| 亚洲欧美中文日韩v在线97| 大黑人交xxxx18视频| 少妇把腿扒开让我爽爽视频| 国产办公室无码视频在线观看| 2021国产成人精品久久| 日本无码欧美一区精品久久| 日日噜噜夜夜狠狠久久无码区| 国产在线高清视频无码| 午夜成人鲁丝片午夜精品| 国产亚洲欧美日韩夜色凹凸成人 | 日韩精品电影综合区亚洲| 国内精品美女a∨在线播放| 久热这里只精品99国产6-99re视…|