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  4. TREML1 Antibody, Biotin conjugated

TREML1 Antibody, Biotin conjugated

  • 中文名稱：
    TREML1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA771477LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TREML1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    dJ238O23.3 antibody; GLTL1825 antibody; MGC119173 antibody; PRO3438 antibody; TLT 1 antibody; TLT-1 antibody; TLT1 antibody; TREM like transcript 1 antibody; Trem like transcript 1 protein antibody; Trem-like transcript 1 protein antibody; TREML 1 antibody; Treml1 antibody; Triggering receptor expressed on myeloid cells like 1 antibody; Triggering receptor expressed on myeloid cells like protein 1 antibody; Triggering receptor expressed on myeloid cells-like protein 1 antibody; TRML1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Trem-like transcript 1 protein (16-162AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cell surface receptor that may play a role in the innate and adaptive immune response.
  • 基因功能參考文獻(xiàn)：
    1. Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels. PMID: 27939925
    2. Levels of sTLT-1 in plasma from patients with potential acute coronary syndrome were compared with an age-matched control group with similar risk factors for cardiovascular disease. PMID: 25147325
    3. Platelet-derived soluble TLT-1 is a potent endogenous regulator of sepsis-associated inflammation. PMID: 22551551
    4. Serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for non-tuberculous mycobacterial lung disease. PMID: 22283904
    5. These results suggest that during inflammation, sTLT-1 may mediate hemostasis by enhancing actin polymerization, resulting in increased platelet aggregation and adherence to the endothelium. PMID: 20093931
    6. initial characterization of TREM-like transcript (TLT)-1 results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors(TLT-1) PMID: 12393607
    7. In contrast to previously characterized immunoreceptor tyrosine-based inhibition motif (ITIM) receptors, TLT1 enhances rather than inhibits calcium signaling in rat RBL-2H3 cells, a property dependent on the SHP-2 recruiting classical Tyr281 ITIM. PMID: 15128762
    8. A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin. PMID: 16505478
    9. Define a platelet specific function for TLT1 in regulation of aggregation. PMID: 17549298
    10. Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1. PMID: 18612537
    11. antibody against the extracellular domain inhibits platelet aggregation in vitro PMID: 19230638
    12. TLT-1 plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury PMID: 19436112

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).
  • 組織特異性：
    Detected in platelets, monocytic leukemia and in T-cell leukemia.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20434

    OMIM: 609714

    KEGG: hsa:340205

    STRING: 9606.ENSP00000402855

    UniGene: Hs.117331



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