在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRAPPC9 Antibody

  • 中文名稱:
    TRAPPC9兔多克隆抗體
  • 貨號:
    CSB-PA024234GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TRAPPC9
  • 別名:
    TRAPPC9 antibody; KIAA1882 antibody; NIBP antibody; T1 antibody; Trafficking protein particle complex subunit 9 antibody; NIK- and IKBKB-binding protein antibody; Tularik gene 1 protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TRAPPC9
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.
  • 基因功能參考文獻:
    1. CNVs significantly contribute to the mutational spectrum of TRAPPC9 gene associated with syndromic intellectual disability. PMID: 29187737
    2. Data show that NIBP expression level is high in gastric cancer (GC) patients and indicate that the NIBPregulated NFkappaB signaling pathway plays a pivotal role in the chemoresistance of GC cells by promoting EMT. PMID: 29620292
    3. Homozygous TRAPPC9 gene nonsense mutation in OXTR gene is associated with intellectual disability, speech disorder, and secondary microcephaly. PMID: 29031008
    4. In this study, we report that WES analysis allowed identification of the causal molecular lesion in both patients. In the first family of Egyptian origin, a homozygous nonsense mutation (c.1423C>T; p.Arg377*) in TRAPPC9 was identified PMID: 27108886
    5. In conclusion, we demonstrated that NIBP knockdown reduces colorectal cancer metastasis through down-regulation of canonical NF-kappaBeta signaling and suppression of ERK and JNK signaling. PMID: 28125661
    6. NIBP impacts on the expression levels of Ecadherin, CD44 and vimentin via the NFkappaB classical and alternative pathways. PMID: 27109343
    7. NIBP reflects a higher metastatic potential of CRC tumors, and its mechanism of action may be through regulation of the classical NF-kappaB pathway and increased MMP-2 and MMP-9 expression PMID: 26596835
    8. Data identified important roles of NIBP in promoting tumorigenesis via NFkappaBeta signaling. PMID: 25704885
    9. Identification and construction of a 3D protein model of trafficking protein particle complex 9 (TRAPPC9), a potetnially interesting molecular target for the development of drug therapy against non syndromic mental retardation PMID: 24040793
    10. By detailed phenotypic analysis of our patients, and by critical literature review, we found that homozygous TRAPPC9 loss-of-function mutations cause a distinctive phenotype, characterized by peculiar facial appearance, obesity, hypotonia PMID: 22549410
    11. A homozygous splice site mutation in TRAPPC9 causes intellectual disability and microcephaly. PMID: 22989526
    12. Data suggest that TRAPPC9 serves to uncouple p150(Glued) from the COPII coat, and to relay the vesicle-dynactin interaction at the target membrane. PMID: 22279557
    13. Data show that a disease-causing mutation of TRAPPC2, D47Y, failed to interact with either TRAPPC9 or TRAPPC8, suggesting that aspartate 47 in TRAPPC2 is at or near the site of interaction with TRAPPC9 or TRAPPC8. PMID: 21858081
    14. Studies indicate that a truncation of TRAPPC9 leads to mental retardation. PMID: 20966969
    15. TRAPPC9 has a role in brain development, possibly through its effect on NF-kappaB activation and protein trafficking in the postmitotic neurons of the cerebral cortex PMID: 20004763
    16. TRAPPC9, encodes the NIK- and IKK-beta-binding protein, has a role in nonsyndromic autosomal-recessive mental retardation PMID: 20004765
    17. NIBP is a NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation PMID: 15951441

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation, autosomal recessive 13 (MRT13)
  • 亞細胞定位:
    Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Cytoplasm.
  • 蛋白家族:
    NIBP family
  • 組織特異性:
    Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.
  • 數據庫鏈接:

    HGNC: 30832

    OMIM: 611966

    KEGG: hsa:83696

    STRING: 9606.ENSP00000373979

    UniGene: Hs.654911



主站蜘蛛池模板: 国产情侣真实露脸在线| 久9热视频这里只精品18| 沈阳45老熟女高潮喷水亮点| а√在线中文网新版地址在线| 亚洲国产aⅴ成人精品无吗| 大香伊蕉在人线国产网站首页| 色六月婷婷亚洲婷婷六月| 亚洲精品久久久久avwww潮水| 国产午夜精品一区理论片飘花| 与子敌伦刺激对白播放的优点| 亚洲精品无码国产| 国产手机在线无码播放视频| 国内精品久久毛片一区二区| 欧洲性久久精品| 亚洲中文无码永久免| 奶头好大狂揉60分钟视频| 国产老妇伦国产熟女老妇视频 | 日本黄页网站免费观看| 中日韩精品卡一卡二卡3卡| 日韩国产综合精选| 大乳丰满人妻中文字幕日本| 精品国产麻豆免费人成网站| 日本japanese丰满多毛| 久久久久久久综合狠狠综合| 中国凸偷窥xxxx自由视频妇科| 日本丰满熟妇乱子伦| 国产美女精品视频线免费播放软件| 亚洲精品一区国产精品| 精品人妻一区二区三区四区在线| 色婷婷综合和线在线| 国产免费二卡3卡四卡| 毛多水多www偷窥小便| 骚片av蜜桃精品一区| 天天综合网亚在线| 精品人伦一区二区三电影| 久久久久久人妻一区二区三区| 国产av一区二区精品凹凸| 亚洲午夜久久久无码精品网红a片| 久久人人爽人人爽人人片av不| 精品一区二区三区无码免费视频| 久拍国产在线观看|