在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRAPPC9 Antibody

  • 中文名稱:
    TRAPPC9兔多克隆抗體
  • 貨號:
    CSB-PA842741LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA842741LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA842741LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) TRAPPC9 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TRAPPC9
  • 別名:
    TRAPPC9 antibody; KIAA1882 antibody; NIBP antibody; T1 antibody; Trafficking protein particle complex subunit 9 antibody; NIK- and IKBKB-binding protein antibody; Tularik gene 1 protein antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Trafficking protein particle complex subunit 9 protein (780-1030AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,TRAPPC9 Antibody (CSB-PA842741LA01HU),的標記方式是Non-conjugated。對于TRAPPC9 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA842741LB01HU TRAPPC9 Antibody, HRP conjugated ELISA
    FITC CSB-PA842741LC01HU TRAPPC9 Antibody, FITC conjugated
    Biotin CSB-PA842741LD01HU TRAPPC9 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.
  • 基因功能參考文獻:
    1. CNVs significantly contribute to the mutational spectrum of TRAPPC9 gene associated with syndromic intellectual disability. PMID: 29187737
    2. Data show that NIBP expression level is high in gastric cancer (GC) patients and indicate that the NIBPregulated NFkappaB signaling pathway plays a pivotal role in the chemoresistance of GC cells by promoting EMT. PMID: 29620292
    3. Homozygous TRAPPC9 gene nonsense mutation in OXTR gene is associated with intellectual disability, speech disorder, and secondary microcephaly. PMID: 29031008
    4. In this study, we report that WES analysis allowed identification of the causal molecular lesion in both patients. In the first family of Egyptian origin, a homozygous nonsense mutation (c.1423C>T; p.Arg377*) in TRAPPC9 was identified PMID: 27108886
    5. In conclusion, we demonstrated that NIBP knockdown reduces colorectal cancer metastasis through down-regulation of canonical NF-kappaBeta signaling and suppression of ERK and JNK signaling. PMID: 28125661
    6. NIBP impacts on the expression levels of Ecadherin, CD44 and vimentin via the NFkappaB classical and alternative pathways. PMID: 27109343
    7. NIBP reflects a higher metastatic potential of CRC tumors, and its mechanism of action may be through regulation of the classical NF-kappaB pathway and increased MMP-2 and MMP-9 expression PMID: 26596835
    8. Data identified important roles of NIBP in promoting tumorigenesis via NFkappaBeta signaling. PMID: 25704885
    9. Identification and construction of a 3D protein model of trafficking protein particle complex 9 (TRAPPC9), a potetnially interesting molecular target for the development of drug therapy against non syndromic mental retardation PMID: 24040793
    10. By detailed phenotypic analysis of our patients, and by critical literature review, we found that homozygous TRAPPC9 loss-of-function mutations cause a distinctive phenotype, characterized by peculiar facial appearance, obesity, hypotonia PMID: 22549410
    11. A homozygous splice site mutation in TRAPPC9 causes intellectual disability and microcephaly. PMID: 22989526
    12. Data suggest that TRAPPC9 serves to uncouple p150(Glued) from the COPII coat, and to relay the vesicle-dynactin interaction at the target membrane. PMID: 22279557
    13. Data show that a disease-causing mutation of TRAPPC2, D47Y, failed to interact with either TRAPPC9 or TRAPPC8, suggesting that aspartate 47 in TRAPPC2 is at or near the site of interaction with TRAPPC9 or TRAPPC8. PMID: 21858081
    14. Studies indicate that a truncation of TRAPPC9 leads to mental retardation. PMID: 20966969
    15. TRAPPC9 has a role in brain development, possibly through its effect on NF-kappaB activation and protein trafficking in the postmitotic neurons of the cerebral cortex PMID: 20004763
    16. TRAPPC9, encodes the NIK- and IKK-beta-binding protein, has a role in nonsyndromic autosomal-recessive mental retardation PMID: 20004765
    17. NIBP is a NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation PMID: 15951441

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Mental retardation, autosomal recessive 13 (MRT13)
  • 亞細胞定位:
    Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Cytoplasm.
  • 蛋白家族:
    NIBP family
  • 組織特異性:
    Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 30832

    OMIM: 611966

    KEGG: hsa:83696

    STRING: 9606.ENSP00000373979

    UniGene: Hs.654911



主站蜘蛛池模板: 亚洲国产成人久久综合同性| 无码一区二区三区av免费| 欧美18精品久久久无码午夜福利| 国产在线拍揄自揄视频导航| 大胆日本熟妇xxxx| 欧美不卡一区二区三区| 亚洲人成影院在线无码按摩店| 日本少妇xxx做受| 午夜男女刺激爽爽影院| 欧美变态另类刺激| 精品无码久久久久国产动漫3d| 亚洲性人人天天夜夜摸18禁止| 亚洲精品中国国产嫩草影院美女| 揄拍成人国产精品视频| 亚洲精品国产福利一区二区| 少妇熟女久久综合网色欲| 老色鬼永久精品网站| 加勒比一本heyzo高清视频| 精品国产乱码久久久久乱码| 欧美成人www免费全部网站| 午夜视频体内射.com.com| 天天躁夜夜踩很很踩2022| 亚洲卡一卡二卡三新区乱码| 中文天堂资源在线www| 人妻 丝袜美腿 中文字幕| 18禁亚洲深夜福利入口| 色婷婷五月综合色啪网| 亚洲一区二区三区丝袜| 国产成人无码av在线影院| 又硬又粗进去好爽免费| 日韩人妻无码免费视频一区二区三区 | 日本japanese漂亮丰满| 伦埋琪琪电影院久久| 小宝贝荡货啊用力水湿aⅴ视频| 久9视频这里只有精品试看| 国产又粗又硬又大爽黄老大爷视频| 国产成人av免费观看| 亚洲一卡一卡二新区迎热烈讨论 | 自拍区小说区图片区亚洲| 成人无码午夜在线观看| 亚洲最大的成人网|