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  4. TRABD2B Antibody, Biotin conjugated

TRABD2B Antibody, Biotin conjugated

  • 中文名稱：
    TRABD2B兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA406235LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TRABD2B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TRABD2B
  • 別名：
    TRABD2B antibody; HKAT antibody; TIKI2 antibody; Metalloprotease TIKI2 antibody; EC 3.4.-.- antibody; Heart antibody; kidney and adipose-enriched transmembrane protein homolog antibody; TRAB domain-containing protein 2B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Metalloprotease TIKI2 protein (195-405AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
  • 基因功能參考文獻：
    1. Results of the present study indicate that TIKI2 is upregulated in renal cell carcinoma tissues and plays an oncogenic role in renal cell carcinoma PMID: 26942462
    2. examination of the structural prediction and identification of the active site residues of human TIKI2 PMID: 26631728
    3. provided evidence that reduced expression of TIKI family protein in osteosarcoma may participate in the progression of osteosarcoma and restoring its expression was able to impair the growth of osteosarcoma PMID: 24771064
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    TIKI family
  • 數據庫鏈接：

    HGNC: 44200

    OMIM: 614913

    KEGG: hsa:388630

    STRING: 9606.ENSP00000456730

    UniGene: Hs.61504



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