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  4. TPST1 Antibody, FITC conjugated

TPST1 Antibody, FITC conjugated

  • 中文名稱：
    TPST1兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA024132LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TPST1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TPST1
  • 別名：
    TPST1; Protein-tyrosine sulfotransferase 1; Tyrosylprotein sulfotransferase 1; TPST-1
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein-tyrosine sulfotransferase 1 protein (283-370AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
  • 基因功能參考文獻：
    1. TPST1 was significantly negatively correlated with the expression of cMet in lung cancer and may be a negative prognostic biomarker of lung cancer. PMID: 26238632
    2. TPST1 rs3757417T>G polymorphisms are associated with colorectal cancer. PMID: 25079514
    3. Affinity purified salivary TPST showed a single band of 50-54 kDa and is the first report characterizing a tyrosylprotein sulfotransferase in secretory fluid from the parotid gland PMID: 16244708
    4. results exclude TPST1 as the causative gene for Shwachman-Diamond syndrome PMID: 12032733
    5. Shear stress-dependent downregulation of TPST1 in human endothelium involves protein kinase C PMID: 12056800
    6. Human tyrosylprotein sulfotransferase may be functional as homodimer/oligomer in the trans-Golgi compartment. PMID: 16859706

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  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Protein sulfotransferase family
  • 組織特異性：
    Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 12020

    OMIM: 603125

    KEGG: hsa:8460

    STRING: 9606.ENSP00000302413

    UniGene: Hs.421194



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