TONSL Antibody, FITC conjugated
-
中文名稱：TONSL兔多克隆抗體, FITC偶聯(lián)
-
貨號：CSB-PA836224LC01HU
-
規(guī)格：￥880
-
其他：
產(chǎn)品詳情
-
產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) TONSL Polyclonal antibody
-
Uniprot No.：
-
基因名：TONSL
-
別名：I kappa B related protein antibody; I-kappa-B-related protein antibody; IkappaBR antibody; IKBR antibody; Inhibitor of kappa B related protein antibody; Inhibitor of kappa B-related protein antibody; MMS22L-interacting protein antibody; MMS22L-interacting protein, NFBIL2/TONSL antibody; NF kappa B inhibitor like protein 2 antibody; NF-kappa-B inhibitor-like protein 2 antibody; NFBIL2 antibody; NFBIL2/TONSL antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2 antibody; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 antibody; Protein IkappaBR antibody; Tonsl antibody; TONSL_HUMAN antibody; Tonsoku-like protein antibody; tonsoku-like, DNA repair protein antibody
-
宿主：Rabbit
-
反應種屬：Human
-
免疫原：Recombinant Human Tonsoku-like protein (668-955AA)
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：FITC
-
克隆類型：Polyclonal
-
抗體亞型：IgG
-
純化方式：>95%, Protein G purified
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
-
功能：Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.
-
基因功能參考文獻：
- By specifically regulating RAD51 activity at uncoupled replication forks, MMS22L-TONSL stabilizes perturbed replication forks by promoting replication fork reversal and stimulating their homologous recombination-mediated restart in vivo. PMID: 27797818
- new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL-MMS22L homologous recombination complex PMID: 27338793
- Common NFKBIL2 polymorphisms are associated with susceptibility to invasive pneumococcal infection. PMID: 21171993
- Results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks. PMID: 21113133
- These results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks. PMID: 21055983
- MMS22L and TONSL are required for the maintenance of genome stability. PMID: 21055984
- This study identifies MMS22L-NFKBIL2 as components of the replication stress control pathway. PMID: 21055985
顯示更多
收起更多
-
亞細胞定位：Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
-
蛋白家族：Tonsoku family
-
組織特異性：Expressed in heart, skeletal muscle and tracheal epithelial cells.
-
數(shù)據(jù)庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
