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  4. TMEM9 Antibody

TMEM9 Antibody

  • 中文名稱：
    TMEM9兔多克隆抗體
  • 貨號：
    CSB-PA023894LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023894LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA023894LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    CUSABIO generates the TMEM9 antibody by immunizing rabbits with the recombinant human TMEM9 (111-183AA). The resulting antibody is a polyclonal antibody and occurs as an unconjugated IgG. It is purified by protein G and reaches up to 95% in purity. And it is only reactive with human TMEM9 protein, which facilitates v-ATPase (vacuolar adenosine triphosphatase) assembly for vesicular acidification and lysosomal protein degradation. Studies have shown that TMEM9 hyperactivates Wnt signaling for liver regeneration and tumorigenesis through lysosomal degradation of APC. This TMEM9 antibody is suitable for the detection of the TMEM9 protein in ELISA and IHC analyses.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TMEM9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TMEM9
  • 別名：
    TMEM9 antibody; DERP4 antibody; TMEM9A antibody; HSPC186 antibody; PSEC0012 antibody; UNQ631/PRO1248 antibody; Transmembrane protein 9 antibody; Dermal papilla-derived protein 4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Transmembrane protein 9 protein (111-183AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，TMEM9 Antibody (CSB-PA023894LA01HU)，的標(biāo)記方式是Non-conjugated。對于TMEM9 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA023894LB01HU TMEM9 Antibody, HRP conjugated ELISA
    FITC CSB-PA023894LC01HU TMEM9 Antibody, FITC conjugated
    Biotin CSB-PA023894LD01HU TMEM9 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking. By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation. TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC. In the liver, involved in hepatic regeneration.
  • 基因功能參考文獻(xiàn)：
    1. TMEM9 plays a significant role in TNF-alpha-enhanced cytokines (IL-6 and IL-1beta) secretion in LX-2 cells and that the canonical Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. PMID: 30119033
    2. TMEM9 knockdown by RNA interference resulted in G1 arrest. PMID: 27220462
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    4. phylogenetically conserved, widely expressed transmembrane protein with a potential, but unknown function in intracellular transport that localizes to lysosomes and late endosomes PMID: 12359240
    5. TMEM9B is a key component of inflammatory signaling pathways and suggest that endosomal or lysosomal compartments regulate these pathways PMID: 18541524

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  • 亞細(xì)胞定位：
    Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    TMEM9 family
  • 組織特異性：
    Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expr
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18823

    OMIM: 616877

    KEGG: hsa:252839

    STRING: 9606.ENSP00000356298

    UniGene: Hs.181444



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