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  4. TMEM9 Antibody, Biotin conjugated

TMEM9 Antibody, Biotin conjugated

  • 中文名稱：
    TMEM9兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA023894LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TMEM9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TMEM9
  • 別名：
    TMEM9 antibody; DERP4 antibody; TMEM9A antibody; HSPC186 antibody; PSEC0012 antibody; UNQ631/PRO1248 antibody; Transmembrane protein 9 antibody; Dermal papilla-derived protein 4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transmembrane protein 9 protein (111-183AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking. By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation. TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC. In the liver, involved in hepatic regeneration.
  • 基因功能參考文獻：
    1. TMEM9 plays a significant role in TNF-alpha-enhanced cytokines (IL-6 and IL-1beta) secretion in LX-2 cells and that the canonical Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. PMID: 30119033
    2. TMEM9 knockdown by RNA interference resulted in G1 arrest. PMID: 27220462
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    4. phylogenetically conserved, widely expressed transmembrane protein with a potential, but unknown function in intracellular transport that localizes to lysosomes and late endosomes PMID: 12359240
    5. TMEM9B is a key component of inflammatory signaling pathways and suggest that endosomal or lysosomal compartments regulate these pathways PMID: 18541524

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  • 亞細胞定位：
    Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    TMEM9 family
  • 組織特異性：
    Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expr
  • 數據庫鏈接：

    HGNC: 18823

    OMIM: 616877

    KEGG: hsa:252839

    STRING: 9606.ENSP00000356298

    UniGene: Hs.181444



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