在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TLE4 Antibody

TLE4 Antibody

  • 中文名稱：
    TLE4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA004300
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of RAT-MUSCLE cells using TLE4 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    TLE4
  • 別名：
    TLE4 antibody; GRG4 antibody; KIAA1261 antibody; Transducin-like enhancer protein 4 antibody; Grg-4 antibody; Groucho-related protein 4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TLE4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
  • 基因功能參考文獻(xiàn)：
    1. the loss of TLE4 confers proliferative advantage to leukemic cells, simultaneous with an upregulation of a pro- inflammatory signature mediated through aberrant increases in Wnt signaling activity PMID: 27486062
    2. the results suggested that TLE4, a potential prognostic biomarker for colorectal cancer, plays an important role in the development and progression of human colorectal cancer. PMID: 26701208
    3. PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. PMID: 25631048
    4. Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 gene induced by BMP7. PMID: 24099773
    5. Displacing coactivators CREB-binding protein/p300 while promoting the recruitment of a corepressor, Grg4. PMID: 22927467
    6. Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation. PMID: 22169276
    7. germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein. PMID: 19893608
    8. Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors PMID: 17060451

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat Groucho/TLE family
  • 組織特異性：
    In all tissues examined, mostly in brain, and muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11840

    OMIM: 605132

    KEGG: hsa:7091

    STRING: 9606.ENSP00000365735

    UniGene: Hs.444213



主站蜘蛛池模板： 免费大黄网站在线观| 国产乱人伦精品免费| 麻豆网神马久久人鬼片| 欧美黑人欧美精品刺激| 97视频热人人精品免费| 中文字幕人妻熟在线影院| 国产一区二区三区在线观看 | 性xxxx搡xxxxx搡欧美| 国产成人精品.视频| 日产精品1区2区3区| 131美女爱做视频免费| 99精品免费久久久久久久久日本| 少妇午夜福利一区二区| 丝袜熟女国偷自产中文字幕亚洲| 野外做受又硬又粗又大视频√| 男ji大巴进入女人的视频| 国产精品色无码av在线观看| 亚洲一卡2卡三卡4卡无卡下载| 97久久人人超碰超碰窝窝| 国产亚洲日韩欧美一区二区三区 | 日韩一本之道一区中文字幕| 色欲视频综合免费天天| 公与淑婷厨房猛烈进出视频免费| 免费看成人aa片无码视频吃奶| 狠狠色综合网站久久久久久久| 极品国产主播粉嫩在线| 人妻精品动漫h无码中字| 国产精品久久国产精品99 gif| 国产精品三级国产电影| 蜜臀av片在线观看| 熟妇人妻系列av无码一区二区| 日本在线看片免费人成视频1000| 精品久久久久久中文墓无码| mm1313亚洲国产精品无码试看| 国产在视频线精品视频| 国产蜜芽尤物在线一区| 精品国产一区二区av麻豆| 日出水了特别黄的视频| 无码精品久久久久久人妻中字| 久久综合九色综合欧洲98| 亚州av综合色区无码一区|