在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TLE4 Antibody, FITC conjugated

TLE4 Antibody, FITC conjugated

  • 中文名稱：
    TLE4兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA523988LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TLE4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TLE4
  • 別名：
    TLE4 antibody; GRG4 antibody; KIAA1261 antibody; Transducin-like enhancer protein 4 antibody; Grg-4 antibody; Groucho-related protein 4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transducin-like enhancer protein 4 protein (284-394AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
  • 基因功能參考文獻：
    1. the loss of TLE4 confers proliferative advantage to leukemic cells, simultaneous with an upregulation of a pro- inflammatory signature mediated through aberrant increases in Wnt signaling activity PMID: 27486062
    2. the results suggested that TLE4, a potential prognostic biomarker for colorectal cancer, plays an important role in the development and progression of human colorectal cancer. PMID: 26701208
    3. PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. PMID: 25631048
    4. Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 gene induced by BMP7. PMID: 24099773
    5. Displacing coactivators CREB-binding protein/p300 while promoting the recruitment of a corepressor, Grg4. PMID: 22927467
    6. Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation. PMID: 22169276
    7. germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein. PMID: 19893608
    8. Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors PMID: 17060451

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat Groucho/TLE family
  • 組織特異性：
    In all tissues examined, mostly in brain, and muscle.
  • 數據庫鏈接：

    HGNC: 11840

    OMIM: 605132

    KEGG: hsa:7091

    STRING: 9606.ENSP00000365735

    UniGene: Hs.444213



主站蜘蛛池模板： 无码一区二区三区在线观看| 国产成人精品无码免费看| 亚洲欧美国产精品久久| 欧美熟妇另类久久久久久多毛| 国产国产久热这里只有精品| 国内偷窥一区二区三区视频| 性xxxx欧美老妇506070| 狠狠色噜噜狠狠狠8888米奇| 国产亚洲精品久久久久久小说| 亚洲国产精品成人精品无码区蜜臀| 国产在线精品99一区不卡| 国内精品久久毛片一区二区| 亚洲欧美精品suv| 国产免费爽爽视频在线观看| 加勒比色综合久久久久久久久| 蜜臀久久99精品久久久久久 | 亚洲人成精品久久久久桥| 日射精情感性色视频| 丰满少妇在线观看网站| 欧美日韩精品人妻狠狠躁免费视频| 国内精品视频自在一区| 水蜜桃精品一二三| 色综合天天综合高清网国产在线| 欧美成人精品三级网站视频| 人妻少妇精品久久| 日本肥老妇色xxxxx日本老妇| 人人爽久久涩噜噜噜av| 天堂在线最新版资源www| 中文字幕中文乱码www| 99视频偷窥在线精品国自产拍| 黑人猛挺进小莹的体内视频| 乱色国内精品视频在线| 国产乱xxⅹxx国语对白| 成人欧美日韩一区二区三区| 欧美日激情日韩精品嗯| 亚洲欧洲日韩综合久久| 国产精品v欧美精品v日韩精品| 亚洲s色大片在线观看| 欧美99久久无码一区人妻a片| 日本xxxx18野外无毒不卡| 欧洲国产伦久久久久久久|