在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TFDP1 Antibody

  • 中文名稱:
    TFDP1兔多克隆抗體
  • 貨號:
    CSB-PA123766
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: CSB-PA123766(TFDP1 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    DP 1 antibody; DP1 antibody; DRTF1 antibody; DRTF1-polypeptide 1 antibody; E2F dimerization partner 1 antibody; E2F related transcription factor antibody; TFDP1 antibody; TFDP1_HUMAN antibody; Transcription factor Dp-1 antibody; Transcription factor sequence-specific, DRTF1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human TFDP1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
  • 基因功能參考文獻:
    1. COMMD9 participates in TFDP1/E2F1 activation and plays a critical role in non-small cell lung cancer. PMID: 27871936
    2. Here, the authors show that an acidic region of DP1, whose function has remained elusive, binds to the plekstrin homology (PH) domain of the p62 subunit of TFIIH that contributes to transcriptional activation. PMID: 27825926
    3. role for E2F1 and TFDP1 in the transcriptional regulation of PITX1 in articular chondrocytes PMID: 27802335
    4. According to our study results, the gene TFDP1 and the cell cycle pathway are strongly associated with high-grade glioblastoma multiforme (GBM); this result may provide new insights into the pathogenesis of GBM. PMID: 27323154
    5. Amplification of CUL4A, IRS2, and TFDP1 genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma. PMID: 26684807
    6. The TFDP1 indel84 mutation generates a gain-of-function phenotype by increasing cell proliferation, migration, and invasion of colorectal cancer cells. PMID: 25133581
    7. somatic mutations in DP-1 uncouple normal control of the E2F pathway, and thus define a new mechanism that could contribute to aberrant proliferation in tumor cells PMID: 23934193
    8. The authors demonstrate that adenovirus E1A binds to E2F/DP-1 complexes through a direct interaction with DP-1 and may selectively activate a subset of E2F-regulated cellular genes during infection. PMID: 21715488
    9. the DP-1 "Stabilon" domain was a C-terminal acidic motif and was quite important for DP-1 stability. PMID: 20513349
    10. 13q34 amplification may be of relevance in tumor progression of breast cancers by inducing overexpression of CUL4A and TFDP1, important in cell cycle regulation. These genes were also overexpressed in non-basal-like tumor samples. PMID: 19995430
    11. TFDP1, CUL4A, and CDC16 are probable targets of an amplification mechanism and therefore may be involved, together or separately, in development and/or progression of some hepatocellular carcinomas PMID: 12029633
    12. expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma PMID: 12607600
    13. TFDP1 may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells PMID: 14618416
    14. DP-1alpha is a novel isoform of DP-1 that acts as a dominant-negative regulator of cell cycle progression PMID: 15863509
    15. DP1 is a critical direct target of ARF. PMID: 16135794
    16. SOCS-3 acts as a negative regulator of the cell cycle progression under E2F/DP-1 control by interfering with heterodimer formation between DP-1 and E2F PMID: 18687693

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    E2F/DP family
  • 組織特異性:
    Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
  • 數據庫鏈接:

    HGNC: 11749

    OMIM: 189902

    KEGG: hsa:7027

    STRING: 9606.ENSP00000364519

    UniGene: Hs.79353



主站蜘蛛池模板: 中文字幕v亚洲ⅴv天堂| 国产精品盗摄!偷窥盗摄| 无码人妻一区二区三区免费看| 老湿机69福利区18禁网站| 成人网站色52色在线观看| 国产精品毛片在线完整版sab| 精品免费国产一区二区三区四区| 亚洲一线二线三线写真| 日韩综合亚洲色在线影院| 国产精品99久久久久久宅男小说| 国产av一区二区三区最新精品 | 亚洲精品电影院| 天干天干夜啦天干天干国产| 亚洲欲色欲香天天综合网| 99久久国产综合精品麻豆| 精品无码午夜福利理论片| 狠狠爱亚洲五月婷婷av| 亚洲图片校园另激情类小说| 久久人妻少妇嫩草av| 日本55丰满熟妇厨房伦| 久久久欧美精品激情| 成人免费午夜无码视频| 欧美午夜一区二区福利视频| 波多野结衣av一区二区全免费观看| 久久久精品妇女99| 国产又色又爽又黄的视频在线| 亚洲精品国产一区二区精华液| 免费无码av片在线观看动漫| 永久免费无码av在线网站| 国产人妻人伦精品1国产盗摄| 国产又色又爽又黄的| 蜜桃日本免费观看mv| 亚洲欧美日韩综合俺去了| 国产成人三级一区二区在线观看一| 日本黄网站三级三级三级 | 国产萌白酱喷水视频在线观看| 精品人伦一区二区三区蜜桃免费 | 国产男女爽爽爽免费视频| 极品美女在线观看免费直播| 欧美乱码卡一卡二卡四卡免费| 成人午夜高潮免费视频|