在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TFDP1 Antibody

  • 中文名稱:
    TFDP1兔多克隆抗體
  • 貨號:
    CSB-PA004264
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HeLa cells using TFDP1 Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    DP 1 antibody; DP1 antibody; DRTF1 antibody; DRTF1-polypeptide 1 antibody; E2F dimerization partner 1 antibody; E2F related transcription factor antibody; TFDP1 antibody; TFDP1_HUMAN antibody; Transcription factor Dp-1 antibody; Transcription factor sequence-specific, DRTF1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human TFDP1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
  • 基因功能參考文獻:
    1. COMMD9 participates in TFDP1/E2F1 activation and plays a critical role in non-small cell lung cancer. PMID: 27871936
    2. Here, the authors show that an acidic region of DP1, whose function has remained elusive, binds to the plekstrin homology (PH) domain of the p62 subunit of TFIIH that contributes to transcriptional activation. PMID: 27825926
    3. role for E2F1 and TFDP1 in the transcriptional regulation of PITX1 in articular chondrocytes PMID: 27802335
    4. According to our study results, the gene TFDP1 and the cell cycle pathway are strongly associated with high-grade glioblastoma multiforme (GBM); this result may provide new insights into the pathogenesis of GBM. PMID: 27323154
    5. Amplification of CUL4A, IRS2, and TFDP1 genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma. PMID: 26684807
    6. The TFDP1 indel84 mutation generates a gain-of-function phenotype by increasing cell proliferation, migration, and invasion of colorectal cancer cells. PMID: 25133581
    7. somatic mutations in DP-1 uncouple normal control of the E2F pathway, and thus define a new mechanism that could contribute to aberrant proliferation in tumor cells PMID: 23934193
    8. The authors demonstrate that adenovirus E1A binds to E2F/DP-1 complexes through a direct interaction with DP-1 and may selectively activate a subset of E2F-regulated cellular genes during infection. PMID: 21715488
    9. the DP-1 "Stabilon" domain was a C-terminal acidic motif and was quite important for DP-1 stability. PMID: 20513349
    10. 13q34 amplification may be of relevance in tumor progression of breast cancers by inducing overexpression of CUL4A and TFDP1, important in cell cycle regulation. These genes were also overexpressed in non-basal-like tumor samples. PMID: 19995430
    11. TFDP1, CUL4A, and CDC16 are probable targets of an amplification mechanism and therefore may be involved, together or separately, in development and/or progression of some hepatocellular carcinomas PMID: 12029633
    12. expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma PMID: 12607600
    13. TFDP1 may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells PMID: 14618416
    14. DP-1alpha is a novel isoform of DP-1 that acts as a dominant-negative regulator of cell cycle progression PMID: 15863509
    15. DP1 is a critical direct target of ARF. PMID: 16135794
    16. SOCS-3 acts as a negative regulator of the cell cycle progression under E2F/DP-1 control by interfering with heterodimer formation between DP-1 and E2F PMID: 18687693

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    E2F/DP family
  • 組織特異性:
    Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11749

    OMIM: 189902

    KEGG: hsa:7027

    STRING: 9606.ENSP00000364519

    UniGene: Hs.79353



主站蜘蛛池模板: 国模大胆一区二区三区| 无码av中文一区二区三区| 在线视+欧美+亚洲日本| 北条麻妃在线一区二区| 无码中文字幕色专区| 国产极品美女到高潮无套| 688欧美人禽杂交狂配| 艳妇荡女欲乱双飞两中年熟妇| 波多野结衣av手机在线观看| 久久综合给综合给久久| 亚洲 欧洲 日韩 综合色天使| 把女邻居弄到潮喷的性经历| 国精产品一二三区传媒公司| 国产精品无码专区在线观看 | 中文人妻无码一区二区三区在线| 国产精品免费看久久久无码| 亚洲三区在线观看无套内射| 欧美亚洲日韩国产综合电影| 国产三级aⅴ在在线观看| 人人爽人人片人人片av| 欧美乱妇高清无乱码免费| 久久精品熟女亚州av麻豆| 国产成人综合一区人人| 台湾无码一区二区| 欧美大屁股xxxx高跟欧美黑人| 一二三四视频在线观看日本| 人妻三级日本香港三级极97| 荫蒂被男人添的好舒服爽免费视频| 国产精品国色综合久久| 亚拍精品一区二区三区探花| 嫩草欧美曰韩国产大片| 欧美特级特黄aaaaaa在线看| 中文字幕热久久久久久久| 巨熟乳波霸若妻在线播放| 亚洲另类激情专区小说| 国产亚洲精品久久久久婷婷瑜伽 | 9九色桋品熟女内射| 夜精品一区二区无码a片| 少妇人妻丰满做爰xxx| 欧美老熟妇又粗又大| 色一情一乱一乱一区99av|