在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TFAP2C Antibody

  • 中文名稱:
    TFAP2C兔多克隆抗體
  • 貨號:
    CSB-PA023416GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TFAP2C
  • 別名:
    Activating enhancer binding protein 2 gamma antibody; Activating enhancer-binding protein 2 gamma antibody; AP2-gamma antibody; AP2C_HUMAN antibody; AP2g antibody; AP2gamma antibody; ERF 1 antibody; ERF1 antibody; Estrogen receptor factor 1 antibody; hAP 2g antibody; hAP2g antibody; TFAP 2C antibody; TFAP 2G antibody; Tfap2c antibody; TFAP2G antibody; Transcription factor AP 2 gamma (activating enhancer binding protein 2 gamma) antibody; Transcription factor AP 2 gamma antibody; Transcription factor AP-2 gamma antibody; Transcription factor ERF 1 antibody; Transcription factor ERF-1 antibody; Transcription factor ERF1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TFAP2C
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
  • 基因功能參考文獻:
    1. Study discovered a novel enhancer HER2 gene body enhancer (HGE) in the 3' gene body of HER2. The HGE activates promoters 1 and 2 in trans., and hence the TFAP2C-mediated transcriptional induction of HER2 expression in breast cancer samples. PMID: 29035388
    2. This study shows that TFAP2C promoted lung tumor progression by upregulation of TGFBR1 and consequent activation of PAK1 signaling. PMID: 27885255
    3. miR-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C in non-small cell lung cancer cells. PMID: 28610956
    4. TFAP2C might increase oncogenic miR-183 expression and consequently downregulate tumor-suppressive AKAP12 and decrease tumor-suppressive miR-33a expression and subsequently induce CDK6 in NSCLC cells. PMID: 27593936
    5. Higher TFAP2C protein expression correlates with poor overall survival after 10 years of diagnosis in ERalpha-positive breast cancer. PMID: 26160249
    6. In all three groups[preeclamptic placentas , healthy control and smokers] expression rates of AP-2gamma did not differ between primary, secondary and tertiary villi. PMID: 25315380
    7. TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer. PMID: 24469049
    8. ShRNA knockdown of AP-2gamma in neuroblastoma cells results in significant inhibit of cell proliferation. PMID: 24969902
    9. Knockdown of TFAP2C or RET inhibited activation of ERK and AKT in MCF-7 cells. Knockdown of TFAP2C, which controls ER (estrogen receptor) and RET, had a greater effect on cell growth than either RET or ER alone. PMID: 24045439
    10. role for TFAP2C in melanoma via its regulation of ECM1 PMID: 24023917
    11. TFAP2C amplification and overexpression represents a genetic dependency in ERBB2+ve breast cancer. PMID: 23334330
    12. TFAP2C regulates expression of the RET proto-oncogene through five AP-2 regulatory sites in the RET promoter. PMID: 22878616
    13. Results demonstrate that TFAP2C regulates the expression of GPX1, which influences the redox state and sensitivity to oxidative stress induced by peroxides. PMID: 22964634
    14. results substantiate a role for Tcfap2c/ TFAP2C in supporting proliferation and repressing differentiation in cellular compartments representing immature/ progenitor cells.[review] PMID: 22560121
    15. We demonstrated that TFAP-2gamma is one of the transcription factors involved in the HuPAR-2 expression in human villous trophoblast cells. PMID: 22702469
    16. demonstrated that while TFAP2C and Myc can downregulate the CDKN1A promoter independently, KDM5B acts as a corepressor dependent on the other two proteins PMID: 22371483
    17. AP-2gamma is a novel collaborative factor in ERalpha-mediated transcription. PMID: 21572391
    18. miR-214 is highly expressed in human melanomas and the data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases through suppression of TFAP2C. PMID: 21468029
    19. Overexpression of TFAP2C is associated with hormone responsive breast carcinoma. PMID: 20629094
    20. AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI. PMID: 11773066
    21. AP-2gamma is important in regulation of ErbB-3 expression in human mammary epithelial and lung fibroblast cells PMID: 11859873
    22. we have identified a potential trophoblast cell-specific regulatory element located 6 kb upstream of the murine AP-2gamma gene transcription start site, and that Sp1 and Sp3 bind to cis-regulatory elements located in the promoter proximal region PMID: 12801994
    23. AP-2gamma expression in breast cancer cells is induced by oestrogens through binding of the oestrogen receptor to a response element within the 5'-untranslated region. PMID: 14565844
    24. Abundant expression of AP-2gamma is associated with intratubular germ cell neoplasias PMID: 15700319
    25. Expression microarray results in human breast carcinoma cells with forced p53 expression revealed AP-2gamma as a putative transcriptional target of p53. PMID: 16636674
    26. TFAP2C is the key regulator of hormone responsiveness in breast carcinoma cells through the control of multiple pathways of estrogen signaling. TFAP2C regulates the expression of ERalpha directly by binding to the ERalpha promoter. PMID: 17875680
    27. Wwox and Ap2gamma emerge are tumor biomarkers that may be superior to PR and Her2 in predicting tamoxifen response PMID: 17947476
    28. AP2 transcription factors may play decisive pacemaker roles in initiating and coordinating budding and branching processes during formation of the fetal breast anlage PMID: 18042070
    29. Down-modulation of AP-2gamma expression in tumor cells by RNA interference led to enhanced tumor growth and reduced chemotherapy-induced cell death, as well as migration and invasion. PMID: 18443366
    30. Reduced expression levels of nuclear AP2gamma is associated with the pathogenesis of basal-like differentiation in breast cancer. PMID: 19130459
    31. Data show that the combination of increasing chromatin accessibility and inducing TFAP2C provides a more robust activation of the ERalpha gene in ERalpha-negative breast cancer cells. PMID: 19458056
    32. ErbB2, CDH2, HPSE and IGSF11 are identified as AP-2gamma target genes in breast cancer cells. PMID: 19671168
    33. AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene. PMID: 19798054

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    AP-2 family
  • 數據庫鏈接:

    HGNC: 11744

    OMIM: 601602

    KEGG: hsa:7022

    STRING: 9606.ENSP00000201031

    UniGene: Hs.473152



主站蜘蛛池模板: av在线播放日韩亚洲欧我不卡| 日本强伦片中文字幕免费看| 国产乱妇乱子在线播放视频| 成人影院yy111111在线| 狠狠色噜噜狠狠狠8888在| 国产美女遭强高潮网站观看| 精品无码一区二区三区av| 久久精品国产亚洲7777| 亚洲欧美日韩国产成人精品影院| 亚洲一二三四2021不卡| 极品少妇扒开粉嫩小泬视频| 欧洲专线一区二区三区| 露脸叫床粗话东北少妇| 国产精品无码一区二区三区电影| 98国产精品综合一区二区三区| 在线观看免费视频污网站| 欧美老肥熟妇多毛xxxxx| 久久久久人妻一区二区三区| 青草青草久热精品视频在线观看| 三级做a全过程在线观看| 亚洲精品无码专区在线| 少妇放荡的呻吟干柴烈火免费视频| 波多野结衣美乳人妻hd电影欧美| 精品无码av不卡一区二区三区| 国产传媒麻豆剧精品av国产| 艳妇乳肉豪妇荡乳在线观看| 无码人妻精品中文字幕免费东京热| 亚洲人成色4444在线观看| 天美传媒精品1区2区3区| 亚欧成人中文字幕一区| 激情爆乳一区二区三区| 无码日韩人妻精品久久| 国产在线观看片a免费观看| 沈阳熟女露脸对白视频| 免费国产裸体美女视频全黄| 玩弄放荡人妻一区二区三区| 国产亚洲中文日本不卡二区| 午夜精品影视国产一区在线麻豆| 51国产偷自视频区视频| 理论片87福利理论电影| 久久综合精品国产一区二区三区无码|