在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TFAP2C Antibody, FITC conjugated

  • 中文名稱:
    TFAP2C兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA842150LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TFAP2C Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TFAP2C
  • 別名:
    Activating enhancer binding protein 2 gamma antibody; Activating enhancer-binding protein 2 gamma antibody; AP2-gamma antibody; AP2C_HUMAN antibody; AP2g antibody; AP2gamma antibody; ERF 1 antibody; ERF1 antibody; Estrogen receptor factor 1 antibody; hAP 2g antibody; hAP2g antibody; TFAP 2C antibody; TFAP 2G antibody; Tfap2c antibody; TFAP2G antibody; Transcription factor AP 2 gamma (activating enhancer binding protein 2 gamma) antibody; Transcription factor AP 2 gamma antibody; Transcription factor AP-2 gamma antibody; Transcription factor ERF 1 antibody; Transcription factor ERF-1 antibody; Transcription factor ERF1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transcription factor AP-2 gamma protein (8-180AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
  • 基因功能參考文獻:
    1. Study discovered a novel enhancer HER2 gene body enhancer (HGE) in the 3' gene body of HER2. The HGE activates promoters 1 and 2 in trans., and hence the TFAP2C-mediated transcriptional induction of HER2 expression in breast cancer samples. PMID: 29035388
    2. This study shows that TFAP2C promoted lung tumor progression by upregulation of TGFBR1 and consequent activation of PAK1 signaling. PMID: 27885255
    3. miR-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C in non-small cell lung cancer cells. PMID: 28610956
    4. TFAP2C might increase oncogenic miR-183 expression and consequently downregulate tumor-suppressive AKAP12 and decrease tumor-suppressive miR-33a expression and subsequently induce CDK6 in NSCLC cells. PMID: 27593936
    5. Higher TFAP2C protein expression correlates with poor overall survival after 10 years of diagnosis in ERalpha-positive breast cancer. PMID: 26160249
    6. In all three groups[preeclamptic placentas , healthy control and smokers] expression rates of AP-2gamma did not differ between primary, secondary and tertiary villi. PMID: 25315380
    7. TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer. PMID: 24469049
    8. ShRNA knockdown of AP-2gamma in neuroblastoma cells results in significant inhibit of cell proliferation. PMID: 24969902
    9. Knockdown of TFAP2C or RET inhibited activation of ERK and AKT in MCF-7 cells. Knockdown of TFAP2C, which controls ER (estrogen receptor) and RET, had a greater effect on cell growth than either RET or ER alone. PMID: 24045439
    10. role for TFAP2C in melanoma via its regulation of ECM1 PMID: 24023917
    11. TFAP2C amplification and overexpression represents a genetic dependency in ERBB2+ve breast cancer. PMID: 23334330
    12. TFAP2C regulates expression of the RET proto-oncogene through five AP-2 regulatory sites in the RET promoter. PMID: 22878616
    13. Results demonstrate that TFAP2C regulates the expression of GPX1, which influences the redox state and sensitivity to oxidative stress induced by peroxides. PMID: 22964634
    14. results substantiate a role for Tcfap2c/ TFAP2C in supporting proliferation and repressing differentiation in cellular compartments representing immature/ progenitor cells.[review] PMID: 22560121
    15. We demonstrated that TFAP-2gamma is one of the transcription factors involved in the HuPAR-2 expression in human villous trophoblast cells. PMID: 22702469
    16. demonstrated that while TFAP2C and Myc can downregulate the CDKN1A promoter independently, KDM5B acts as a corepressor dependent on the other two proteins PMID: 22371483
    17. AP-2gamma is a novel collaborative factor in ERalpha-mediated transcription. PMID: 21572391
    18. miR-214 is highly expressed in human melanomas and the data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases through suppression of TFAP2C. PMID: 21468029
    19. Overexpression of TFAP2C is associated with hormone responsive breast carcinoma. PMID: 20629094
    20. AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI. PMID: 11773066
    21. AP-2gamma is important in regulation of ErbB-3 expression in human mammary epithelial and lung fibroblast cells PMID: 11859873
    22. we have identified a potential trophoblast cell-specific regulatory element located 6 kb upstream of the murine AP-2gamma gene transcription start site, and that Sp1 and Sp3 bind to cis-regulatory elements located in the promoter proximal region PMID: 12801994
    23. AP-2gamma expression in breast cancer cells is induced by oestrogens through binding of the oestrogen receptor to a response element within the 5'-untranslated region. PMID: 14565844
    24. Abundant expression of AP-2gamma is associated with intratubular germ cell neoplasias PMID: 15700319
    25. Expression microarray results in human breast carcinoma cells with forced p53 expression revealed AP-2gamma as a putative transcriptional target of p53. PMID: 16636674
    26. TFAP2C is the key regulator of hormone responsiveness in breast carcinoma cells through the control of multiple pathways of estrogen signaling. TFAP2C regulates the expression of ERalpha directly by binding to the ERalpha promoter. PMID: 17875680
    27. Wwox and Ap2gamma emerge are tumor biomarkers that may be superior to PR and Her2 in predicting tamoxifen response PMID: 17947476
    28. AP2 transcription factors may play decisive pacemaker roles in initiating and coordinating budding and branching processes during formation of the fetal breast anlage PMID: 18042070
    29. Down-modulation of AP-2gamma expression in tumor cells by RNA interference led to enhanced tumor growth and reduced chemotherapy-induced cell death, as well as migration and invasion. PMID: 18443366
    30. Reduced expression levels of nuclear AP2gamma is associated with the pathogenesis of basal-like differentiation in breast cancer. PMID: 19130459
    31. Data show that the combination of increasing chromatin accessibility and inducing TFAP2C provides a more robust activation of the ERalpha gene in ERalpha-negative breast cancer cells. PMID: 19458056
    32. ErbB2, CDH2, HPSE and IGSF11 are identified as AP-2gamma target genes in breast cancer cells. PMID: 19671168
    33. AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene. PMID: 19798054

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    AP-2 family
  • 數據庫鏈接:

    HGNC: 11744

    OMIM: 601602

    KEGG: hsa:7022

    STRING: 9606.ENSP00000201031

    UniGene: Hs.473152



主站蜘蛛池模板: 人与狗精品aa毛片| 欧洲亚洲国产成人综合色婷婷| 日本久久久久久级做爰片| 色综合久久久无码网中文| 高大丰满熟妇丰满的大白屁股| 亚洲va中文字幕无码久久不卡| 欧美国产激情18| 久久国国产免费999| 初尝人妻少妇中文字幕| 国产精华av午夜在线观看| 性人久久久久| 高清国产在线拍揄自揄视频| 99久久人妻无码精品系列| 午夜免费啪视频观看视频| 无码人妻丰满熟妇区毛片18| 涩涩鲁亚洲精品一区二区| 久久婷婷激情综合色综合俺也去| 青青草av国产精品| 人妻少妇邻居少妇好多水在线| 热99re久久精品这里都是精品免费 | 免费网站观看www在线观看| 国产md视频一区二区三区| 少妇又紧又深又湿又爽视频| 一个人看的www视频免费观看 | 国产精品人妻一区夜夜爱| 无码人妻丰满熟妇区毛片18| 欧美韩中文精品有码视频在线 | 97无码免费人妻超级碰碰碰碰| 精品一区二区成人精品| 亚洲国产成人无码精品| 欧美日韩精品| 欧美老妇交乱视频在线观看 | 欧美中文字幕无线码视频| 男女猛烈无遮挡免费视频app| 少妇富婆高级按摩出水高潮| 在线亚洲人成电影网站色www| 亚洲色成人网站www永久四虎 | 国产av毛片亚洲含羞草社| 人妻aⅴ中文字幕无码| 中文字幕乱码在线人视频| 两口子交换真实刺激高潮|