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  4. TENM1 Antibody

TENM1 Antibody

  • 中文名稱：
    TENM1兔多克隆抗體
  • 貨號：
    CSB-PA892339LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA892339LA01HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TENM1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    TENM1 antibody; ODZ1 antibody; TNM1 antibody; Teneurin-1 antibody; Ten-1 antibody; Protein Odd Oz/ten-m homolog 1 antibody; Tenascin-M1 antibody; Ten-m1 antibody; Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain antibody; IDten-1 antibody; Ten-1 ICD); Teneurin C-terminal-associated peptide antibody; TCPA-1 antibody; Ten-1 extracellular domain antibody; Ten-1 ECD)] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Teneurin-1 protein (1-241AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，TENM1 Antibody (CSB-PA892339LA01HU)，的標記方式是Non-conjugated。對于TENM1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA892339LB01HU TENM1 Antibody, HRP conjugated ELISA
    FITC CSB-PA892339LC01HU TENM1 Antibody, FITC conjugated
    Biotin CSB-PA892339LD01HU TENM1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer.; Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking.; Induces gene transcription activation.
  • 基因功能參考文獻：
    1. Taken together, the results indicate that distinct pathways are involved in papillary thyroid cancer progression, and TENM1 is a potential marker of cancer progression. PMID: 28004221
    2. ODZ1, a protein that participates in the embryonic development of the brain, is also involved in cancer progression by promoting the growth and invasion capabilities of GSCs via a transcriptional pathway that induces the expression of RhoA and activation of downstream ROCK. PMID: 27641332
    3. Results of our study, that describes a new Tenm1 mouse, agree with the hypothesis that TENM1 has a role in olfaction. However, additional studies should be done in larger Congenital general anosmia (CGA) cohorts, to provide statistical evidence that loss-of-function mutations in TENM1 can solely cause the disease in our and other CGA cases PMID: 27040985
    4. Data suggest teneurin-1/TENM1 (and possibly TENM3) undergoes proteolysis to TCAPs (teneurin C-terminal associated peptides) that form intercellular adhesive units with latrophilin; signaling via TENM1 TCAPs appears to regulate reproduction. [REVIEW] PMID: 26485751
    5. This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes TENM1. PMID: 25666757
    6. Studies indicate that teneurin-1 has been suggested as a candidate target gene for X-lined mental retardation. PMID: 25152333
    7. The teneurin-1 intracellular domain binds HINT1, thus switching on MITF-dependent transcription of GPNMB. PMID: 25648896
    8. Subsequent analysis showed that the deletion in both cousins was identical and involved the whole SH2D1A gene and a part of the adjacent ODZ1 gene. PMID: 22271700
    9. Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1. PMID: 21651764
    10. teneurin-1 plays a role in intracellular signaling PMID: 15777793

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  • 亞細胞定位：
    Cell membrane; Single-pass membrane protein.; [Ten-1 intracellular domain]: Nucleus. Nucleus speckle. Nucleus matrix. Cytoplasm, cytoskeleton.; [Teneurin C-terminal-associated peptide]: Nucleus. Cytoplasm. Cell membrane.
  • 蛋白家族：
    Tenascin family, Teneurin subfamily
  • 組織特異性：
    Expressed in fetal brain.
  • 數據庫鏈接：

    HGNC: 8117

    OMIM: 300588

    KEGG: hsa:10178

    STRING: 9606.ENSP00000403954

    UniGene: Hs.23796



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