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  4. TCN1 Antibody, HRP conjugated

TCN1 Antibody, HRP conjugated

  • 中文名稱：
    TCN1兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA023317LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TCN1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TCN1
  • 別名：
    Haptocorin antibody; Haptocorrin antibody; HC antibody; OTTHUMP00000235879 antibody; TC 1 antibody; TC I antibody; TC-1 antibody; TC1 antibody; TCI antibody; TCN 1 antibody; TCN1 antibody; TCO1_HUMAN antibody; Transcobalamin 1 antibody; Transcobalamin I antibody; Transcobalamin-1 antibody; Transcobalamin1 antibody; TranscobalaminI antibody; Vitamin B12 binding protein antibody; Vitamin B12 binding protein R binder family antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Transcobalamin-1 protein (24-433AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
  • 基因功能參考文獻：
    1. Higher placental TC protein abundance was associated with higher cord blood vitamin B12 concentrations, suggesting a potential role in vitamin B12 transport to the fetus. PMID: 27577703
    2. The variant rs526934 from the TCN1 gene was associated with an increased risk of developing gastric cancer. PMID: 26959381
    3. Levels of holotranscobalamin are decreased patients with cobalamin deficiency. PMID: 24057896
    4. Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin. PMID: 23846701
    5. TCN1 gene expression implicates disease progression in patient with middle ear cholesteatoma. PMID: 23670528
    6. comparison of human and rainbow trout cobalamin-binding protein PMID: 22872637
    7. Elevated concentrations of B(12) found in autoimmune lymphoproliferative syndrome patients were due to increased lymphocyte expression of haptocorrin. PMID: 22306884
    8. Stromal expression of KRT15, TCN1, and HOXB13 was significantly correlated with tumor grade, stromal hypercellularity, mitotic activity and microscopic borders. PMID: 21574054
    9. two novel mutations, each causing a premature stop codon - a genetic basis for TC I deficiency PMID: 19686235
    10. Comparative analysis of cobalamin binding kinetics PMID: 11788601
    11. No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. PMID: 12590948
    12. interactions of COBALAMIN BINDING proteins with a number of ligands PMID: 17487979
    13. Maternal folate-related polymorphisms studied here (CBS, MTR, RFC-1, and TC) have no influence on trisomy 21 susceptibility in subjects of Brazilian population.v PMID: 19729796

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Eukaryotic cobalamin transport proteins family
  • 組織特異性：
    Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11652

    OMIM: 189905

    KEGG: hsa:6947

    STRING: 9606.ENSP00000257264

    UniGene: Hs.2012



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