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TCN1 Antibody, Biotin conjugated

  • 中文名稱:
    TCN1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA023317LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TCN1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TCN1
  • 別名:
    Haptocorin antibody; Haptocorrin antibody; HC antibody; OTTHUMP00000235879 antibody; TC 1 antibody; TC I antibody; TC-1 antibody; TC1 antibody; TCI antibody; TCN 1 antibody; TCN1 antibody; TCO1_HUMAN antibody; Transcobalamin 1 antibody; Transcobalamin I antibody; Transcobalamin-1 antibody; Transcobalamin1 antibody; TranscobalaminI antibody; Vitamin B12 binding protein antibody; Vitamin B12 binding protein R binder family antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transcobalamin-1 protein (24-433AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
  • 基因功能參考文獻:
    1. Higher placental TC protein abundance was associated with higher cord blood vitamin B12 concentrations, suggesting a potential role in vitamin B12 transport to the fetus. PMID: 27577703
    2. The variant rs526934 from the TCN1 gene was associated with an increased risk of developing gastric cancer. PMID: 26959381
    3. Levels of holotranscobalamin are decreased patients with cobalamin deficiency. PMID: 24057896
    4. Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin. PMID: 23846701
    5. TCN1 gene expression implicates disease progression in patient with middle ear cholesteatoma. PMID: 23670528
    6. comparison of human and rainbow trout cobalamin-binding protein PMID: 22872637
    7. Elevated concentrations of B(12) found in autoimmune lymphoproliferative syndrome patients were due to increased lymphocyte expression of haptocorrin. PMID: 22306884
    8. Stromal expression of KRT15, TCN1, and HOXB13 was significantly correlated with tumor grade, stromal hypercellularity, mitotic activity and microscopic borders. PMID: 21574054
    9. two novel mutations, each causing a premature stop codon - a genetic basis for TC I deficiency PMID: 19686235
    10. Comparative analysis of cobalamin binding kinetics PMID: 11788601
    11. No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. PMID: 12590948
    12. interactions of COBALAMIN BINDING proteins with a number of ligands PMID: 17487979
    13. Maternal folate-related polymorphisms studied here (CBS, MTR, RFC-1, and TC) have no influence on trisomy 21 susceptibility in subjects of Brazilian population.v PMID: 19729796

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  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Eukaryotic cobalamin transport proteins family
  • 組織特異性:
    Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.
  • 數據庫鏈接:

    HGNC: 11652

    OMIM: 189905

    KEGG: hsa:6947

    STRING: 9606.ENSP00000257264

    UniGene: Hs.2012



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