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TBC1D1 Antibody

  • 中文名稱:
    TBC1D1兔多克隆抗體
  • 貨號:
    CSB-PA082079
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA082079(TBC1D1 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA082079(TBC1D1 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    KIAA1108 antibody; TBC 1 antibody; TBC antibody; TBC1 (tre 2/USP6; BUB2; cdc16) domain family; member 1 antibody; TBC1 antibody; TBC1 domain family member 1 antibody; Tbc1d1 antibody; TBCD1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human TBC1D1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:40-1:150
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells.
  • 基因功能參考文獻:
    1. TBC1D1-Ser(231) phosphorylation and/or 14-3-3 binding partially mediates AMPK-governed glucose homeostasis and muscle glucose uptake in a context-dependent manner. PMID: 27826658
    2. data demonstrate heterozygous deactivating TBC1D1 mutations in CAKUT patients with a similar renal and ureteral phenotype, and provide evidence that TBC1D1 mutations may contribute to CAKUT PMID: 26572137
    3. AS160 and TBC1D1 phosphorylations were evident 30 min after exercise. PMID: 24876356
    4. Data show that TBC1D1 is expressed and phosphorylated in response to glucose in these cells. PMID: 24239544
    5. Moderate association of rs9852 indicates an influence of TBC1D1 for antipsychotic-induced weight gain. PMID: 23364847
    6. R125W mutation occurs in a location of the TBC1D1 PTB domain that is predicted to have a function in a putative protein:protein interaction. PMID: 23667688
    7. Data suggest that insulin increases phosphorylation of signaling nexus TBC1D1 independent of prior exercise or lipid/Intralipid administration. PMID: 22851577
    8. TBC1D1 is Ser237 phosphorylated and binding capacity to 14-3-3 protein is increased in skeletal muscle following exercise. PMID: 20837646
    9. [review] The question of a mechanism for increased phosphorylation of Ser237-TBC1D1 after exercise has, so far, not had a straightforward experimental approach for a direct answer in humans undergoing in vivo exercise. PMID: 21078596
    10. A single bout of exercise regulates TBC1D1 and AS160 phosphorylation on multiple sites in human skeletal muscle. PMID: 21505148
    11. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. PMID: 21454505
    12. coding variant R125W affects obesity susceptibility, delimits the location of an obesity gene at 4q34-35 and identifies a gene/gene interaction that influences the risk for obesity predisposition PMID: 16893906
    13. form of Tbc1d1 also inhibited GLUT4 translocation and that this effect also required a functional GAP domain PMID: 17274760
    14. These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition. PMID: 18325908

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  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 11578

    OMIM: 609850

    KEGG: hsa:23216

    STRING: 9606.ENSP00000261439

    UniGene: Hs.176503



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