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  4. SWAP70 Antibody

SWAP70 Antibody

  • 中文名稱(chēng)：
    SWAP70兔多克隆抗體
  • 貨號(hào)：
    CSB-PA870303
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA870303(SWAP70 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using CSB-PA870303(SWAP70 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SWAP70
  • 別名：
    KIAA0640 antibody; 70kDa antibody; AV235546 antibody; FLJ39540 antibody; HSPC321 antibody; SWA 70 protein antibody; SWAP 70 antibody; SWAP switching B-cell complex 70kDa subunit antibody; SWAP-70 antibody; SWAP70 antibody; Switch associated protein 70 antibody; Switch-associated protein 70 antibody; SWP70_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human SWAP70
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
  • 基因功能參考文獻(xiàn)：
    1. Expression of switch-associated protein 70 is associated with lymphocyte activation and reduced disability in multiple sclerosis. PMID: 27495372
    2. These data show a key role for SWAP70 as a scaffold for tethering the peripheral actin cage to phagosomes. PMID: 27806292
    3. SWAP70 appears to act as a molecular intermediate between vGPCR and endothelial activation. PMID: 25889342
    4. SWAP70 may be a target of miR-145, and it might have a potential oncogenic function. PMID: 21360565
    5. Detection of SWAP70 antibodies during the attack period might suggest that SWAP70 is involved in Multiple Sclerosis relapse pathogenesis PMID: 22728961
    6. The unwinding of the C-terminal alpha-helix could regulate the functions of SWAP-70 at the plasma membrane surface. PMID: 22247562
    7. findings suggest that regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure PMID: 22210919
    8. protein that functions as the only B cell-specific component of an isotype switch recombination PMID: 11726218
    9. Overexpression of SWAP-70 altered the actin organization and lamellipodial morphology PMID: 12925760
    10. the binding activity of SWAP-70 to non-muscle F-actin is required for membrane ruffling. PMID: 16418221
    11. surface expression of SWAP-70 on HIV-1 infected cells as well as PBMCs; SWAP-70 may serve as a marker for T cell differentiation as well as for HIV-1 infection PMID: 16547421
    12. SWAP-70 may be involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation in primates. PMID: 17371938

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Cytoplasm, cytoskeleton.
  • 組織特異性：
    Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue. Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17070

    OMIM: 604762

    KEGG: hsa:23075

    STRING: 9606.ENSP00000315630

    UniGene: Hs.153026



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