在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUPT4H1 Antibody

  • 中文名稱:
    SUPT4H1兔多克隆抗體
  • 貨號:
    CSB-PA022957ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA022957ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA022957ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SUPT4H1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SUPT4H1
  • 別名:
    DRB sensitivity-inducing factor 14 kDa subunit antibody; DRB sensitivity-inducing factor small subunit antibody; DSIF p14 antibody; DSIF small subunit antibody; hSPT4 antibody; SPT4 antibody; SPT4H antibody; SPT4H_HUMAN antibody; SUPT4H `1 antibody; SUPT4H antibody; Supt4h1 antibody; Transcription elongation factor spt4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transcription elongation factor SPT4 protein (1-117AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
  • 基因功能參考文獻:
    1. Chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 was found to occur frequently in primary colorectal carcinoma. PMID: 27461012
    2. Knockdown of SUPT4H1, the human Spt4 ortholog, similarly decreased production of sense and antisense RNA foci, as well as dipeptide repeat proteins, in patient cells. PMID: 27516603
    3. crystal structure of hSpt4 in complex with the dimerization region of hSpt5 PMID: 19860741
    4. Upon induction of NF-kappaB, a subset of target genes is regulated differentially by either P-TEFb or DSIF.[P-TEFb, DSIF] PMID: 17502349
    5. These findings reveal a dynamic regulation of DSIF involving either E-box or NF-kappaB depending on the physiological circumstances. PMID: 17962196
    6. Spt4 was purified and characterized. PMID: 18373978
    7. These results suggest that one of the functions of Spt5 is to suppress senescence and apoptosis, and that this function is exerted through its association with Spt4 and Pol II. PMID: 19210550
    8. he Paf1 complex (Paf1C) and Tat-SF1, two factors implicated previously in elongation control, collaborate with DSIF to facilitate efficient elongation PMID: 19952111

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    SPT4 family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 11467

    OMIM: 603555

    KEGG: hsa:6827

    STRING: 9606.ENSP00000225504

    UniGene: Hs.439481



主站蜘蛛池模板: 一二三四视频社区在线| 久久久不卡国产精品一区二区| 四虎永久在线精品免费一区二区| 亚洲熟女乱色综合亚洲小说| 国产内射老熟女aaaa∵| 国产美女a做受大片观看| 国产精品欧美成人| 亚洲综合av在线在线播放| 国产成人精品三上悠亚| 亚洲高清国产av拍精品青青草原| 欧美白人最猛性xxxxx| 99久久99久久久精品齐齐| 亚洲a∨无码一区二区| 一区二区三区四区在线 | 中国| 撕开奶罩揉吃奶高潮av在线观看| 中文字幕无码免费久久99| 国自产拍偷拍精品啪啪一区二区| 秋霞午夜久久午夜精品| 99精品国产在热久久无毒| 国产大片黄在线观看私人影院| 久久精品国产大片免费观看| 天堂资源中文最新版在线一区| 无码人妻少妇久久中文字幕蜜桃 | 在线亚洲97se亚洲综合在线| 亚洲自偷精品视频自拍| 丰满少妇女裸体bbw| 日本十八禁黄无遮禁视频免费| 欧美 日韩 国产 另类 图片区| 97久久精品人妻人人搡人人玩| 久久国产精品一国产精品 | 人妻巨大乳hd免费看| 樱花草在线社区www| 学生精品国产在线视频| 成人亚洲a片v一区二区三区动漫| 无码人妻aⅴ一区二区三区| 久久久天堂国产精品女人| 亚色九九九全国免费视频| 无码人妻一区二区三区av| 无遮挡国产高潮视频免费观看| 亚洲一区二区制服在线| 狠狠色噜噜狠狠狠狠777米奇小说|