在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUPT4H1 Antibody

  • 中文名稱:
    SUPT4H1兔多克隆抗體
  • 貨號:
    CSB-PA022957ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA022957ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA022957ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SUPT4H1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SUPT4H1
  • 別名:
    DRB sensitivity-inducing factor 14 kDa subunit antibody; DRB sensitivity-inducing factor small subunit antibody; DSIF p14 antibody; DSIF small subunit antibody; hSPT4 antibody; SPT4 antibody; SPT4H antibody; SPT4H_HUMAN antibody; SUPT4H `1 antibody; SUPT4H antibody; Supt4h1 antibody; Transcription elongation factor spt4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transcription elongation factor SPT4 protein (1-117AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
  • 基因功能參考文獻:
    1. Chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 was found to occur frequently in primary colorectal carcinoma. PMID: 27461012
    2. Knockdown of SUPT4H1, the human Spt4 ortholog, similarly decreased production of sense and antisense RNA foci, as well as dipeptide repeat proteins, in patient cells. PMID: 27516603
    3. crystal structure of hSpt4 in complex with the dimerization region of hSpt5 PMID: 19860741
    4. Upon induction of NF-kappaB, a subset of target genes is regulated differentially by either P-TEFb or DSIF.[P-TEFb, DSIF] PMID: 17502349
    5. These findings reveal a dynamic regulation of DSIF involving either E-box or NF-kappaB depending on the physiological circumstances. PMID: 17962196
    6. Spt4 was purified and characterized. PMID: 18373978
    7. These results suggest that one of the functions of Spt5 is to suppress senescence and apoptosis, and that this function is exerted through its association with Spt4 and Pol II. PMID: 19210550
    8. he Paf1 complex (Paf1C) and Tat-SF1, two factors implicated previously in elongation control, collaborate with DSIF to facilitate efficient elongation PMID: 19952111

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    SPT4 family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 11467

    OMIM: 603555

    KEGG: hsa:6827

    STRING: 9606.ENSP00000225504

    UniGene: Hs.439481



主站蜘蛛池模板: 国产精品视频| 中文综合在线观| 国产精品爽黄69天堂a| 国产精品久久久久久成人影院| 亚洲乱亚洲乱妇24p| 黄页网站在线观看免费视频| 国产丰满麻豆vⅰde0sex| 美女裸免费观看网站| 亚洲国产欧美在线人成| 四虎国产精品永久在线观看| 3d动漫精品啪啪一区二区免费 | 日韩精品中文字幕无码一区| 狠狠色成人一区二区三区| 2021最新国产在线人成| 97人摸人人澡人人人超碰| 亚洲情综合五月天| 成人h视频在线观看| 波多野结衣av在线无码中文18| 国产按头口爆吞精在线视频| 麻花传媒mv国产免费观看视频| 免费三级网站| 香港三级韩国三级日本三级| 99精品国产福利在线观看| 婷婷五月综合国产激情| 伊人色合天天久久综合网| 国产特级毛片aaaaaaa高清 | 99久久久无码国产精品秋霞网| 欧美乱码伦视频免费| 国语自产拍在线观看对白| 日韩av片无码一区二区不卡电影| 国产麻豆精品一区| 精品爆乳一区二区三区无码av| 中文字幕乱人伦高清视频| 天堂网在线www中文| 国产日产久久高清欧美一区| 国产男女爽爽爽免费视频| 久久综合精品无码av一区二区三区| 日韩精品一卡2卡3卡4卡新区| 中文国产成人精品久久app| 午夜性刺激免费看视频| 久久精品无码一区二区日韩av|