在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUPT4H1 Antibody

  • 中文名稱:
    SUPT4H1兔多克隆抗體
  • 貨號:
    CSB-PA022957ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA022957ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA022957ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SUPT4H1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SUPT4H1
  • 別名:
    DRB sensitivity-inducing factor 14 kDa subunit antibody; DRB sensitivity-inducing factor small subunit antibody; DSIF p14 antibody; DSIF small subunit antibody; hSPT4 antibody; SPT4 antibody; SPT4H antibody; SPT4H_HUMAN antibody; SUPT4H `1 antibody; SUPT4H antibody; Supt4h1 antibody; Transcription elongation factor spt4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transcription elongation factor SPT4 protein (1-117AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
  • 基因功能參考文獻:
    1. Chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 was found to occur frequently in primary colorectal carcinoma. PMID: 27461012
    2. Knockdown of SUPT4H1, the human Spt4 ortholog, similarly decreased production of sense and antisense RNA foci, as well as dipeptide repeat proteins, in patient cells. PMID: 27516603
    3. crystal structure of hSpt4 in complex with the dimerization region of hSpt5 PMID: 19860741
    4. Upon induction of NF-kappaB, a subset of target genes is regulated differentially by either P-TEFb or DSIF.[P-TEFb, DSIF] PMID: 17502349
    5. These findings reveal a dynamic regulation of DSIF involving either E-box or NF-kappaB depending on the physiological circumstances. PMID: 17962196
    6. Spt4 was purified and characterized. PMID: 18373978
    7. These results suggest that one of the functions of Spt5 is to suppress senescence and apoptosis, and that this function is exerted through its association with Spt4 and Pol II. PMID: 19210550
    8. he Paf1 complex (Paf1C) and Tat-SF1, two factors implicated previously in elongation control, collaborate with DSIF to facilitate efficient elongation PMID: 19952111

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    SPT4 family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 11467

    OMIM: 603555

    KEGG: hsa:6827

    STRING: 9606.ENSP00000225504

    UniGene: Hs.439481



主站蜘蛛池模板: 精品人妻无码一区二区三区蜜桃一| 凸偷窥中国女人洗澡| 天天槽夜夜槽槽不停| 国产欧美日韩中文久久| 国产又黄又猛又粗又爽的a片动漫 成年女性特黄午夜视频免费看 | 制服丝袜有码中文字幕在线| 中国少妇xxxx做受| 国语自产少妇精品视频| 少妇愉情理伦片丰满丰满午夜| 337p亚洲日本中国大胆69| 中日韩产精品1卡二卡三卡| 超碰国产精品久久国产精品99| 国产suv精品一区二人妻| 久久人妻国产精品| 午夜激成人免费视频在线观看 | 亚洲欧美日韩综合在线一| 精品久久久久久亚洲中文字幕| 国产又粗又猛又爽又黄的视频在线观看动漫 | 一二三四区无产乱码1000集| 欧美xxxx黑人又粗又长精品| 亚洲精品一区二区丝袜图片| 久青草国产97香蕉在线视频| 欧美大胆少妇bbw| 无码精品国产一区二区三区免费| 尤物色综合欧美五月俺也去 | 婷婷四房色播| 国产视频亚洲精品视频| 国产吃奶在线观看| 亚洲人成网站18禁止无码| 久久国产主播福利在线| 亚洲va中文字幕无码久久不卡| 国产成人av一区二区三区不卡| 欧美破苞系列二十三| 乱人伦视频中文字幕| 国产色a在线观看| 亚洲乱码日产精品bd在线观看| 电影内射视频免费观看| 日本二区三区欧美亚洲国产| 老熟妇仑乱一区二区视頻| 国产69精品久久久久久妇女迅雷| 亚洲成av人影院无码不卡|