在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SULT2B1 Antibody

SULT2B1 Antibody

  • 中文名稱：
    SULT2B1兔多克隆抗體
  • 貨號：
    CSB-PA144328
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA144328(SULT2B1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SULT2B1
  • 別名：
    Alcohol sulfotransferase antibody; EC 2.8.2.2 antibody; HSST2 antibody; Hydroxysteroid sulfotransferase 2 antibody; ST2B1 antibody; ST2B1_HUMAN antibody; Sulfotransferase 2B1 antibody; Sulfotransferase family cytosolic 2B member 1 antibody; SULT2B1 antibody; SULT2B1a antibody; SULT2B1b antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human SULT2B1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation.; Sulfonates pregnenolone but not cholesterol.
  • 基因功能參考文獻：
    1. findings showed clearly the impact of genetic polymorphisms on the cholesterol-sulphating activity of SULT2B1b allozymes, which may underscore the differential metabolism of cholesterol in individuals with different SULT2B1b genotypes PMID: 29701841
    2. Mutation in SULT2B1 leads to an autosomal-recessive congenital ichthyosis phenotype via increased proliferation of human keratinocytes, thickening of epithelial layers, and altered epidermal cholesterol metabolism. PMID: 28575648
    3. Since 1'-hydroxyestragole exposure readily produced DNA injury in B-13/H cells, these data suggest that cholangiocarcinomas generated in rats fed estragole may be dependent, in part, on SULT2B1 activation of the 1'-hydroxyestragole metabolite. PMID: 26739637
    4. Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma. PMID: 26121319
    5. This study identified specific germline variations in estradiol metabolism-related pathways, namely CYP1B1, SULT2B1, and HSD17B2, as novel prognostic markers that are cumulatively associated with increased risk of prostate cancer progression PMID: 24682418
    6. The SULT2B1 isoforms have a unique 50 amino acid carboxy-terminal sequence that is not present in the other human SULT isoforms (review). PMID: 24020383
    7. Data indicate that cholesterol sulfate (CS) and SULT2B1b inhibited gluconeogenesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (HNF4alpha) in both cell cultures and human SULT2B1b transgenic mice. PMID: 24277929
    8. SULT2B1 is induced by calcitriol activated vitamin D receptor in human prostate cancer cells. PMID: 23579488
    9. SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of HCC. PMID: 23593328
    10. In HT29 cells expression of SULT2B1 was enhanced by probiotic fermentation supernatants without aleurone. PMID: 21840698
    11. The Ca(2+)-bound form may be physiologically relevant for stressed cells with an elevated free calcium level. PMID: 20329768
    12. The expression of SULT2B1b mRNA in endometrial stromal cells is induced by progesterone and that in endometrial epithelial cells is induced by relaxin via the cAMP pathway. PMID: 19243756
    13. alternative splicing of SULT2B1 results in cholesterol sulfotransferase or pregnenolone sulfotransferase PMID: 12145317
    14. crystal structure of hydroxysteroid sulfotransferases SULT2B1a and SULT2B1b bound to the substrate donor product 3'-phosphoadenosine 5'-phosphate and acceptor substrate pregnenolone revealed a different catalytic binding orientation PMID: 12923182
    15. We have documented the presence of the enzyme (SULT2B1b) that sulfonates cholesterol in human platelets and examined the influence of plasma lipoproteins on the expression and activity of this enzyme PMID: 14676143
    16. Differential subcellular localization of SULT2B1b in prostate and placenta suggests that SULT2B1b may be differentially regulated and have different physiological functions in these two hormonally responsive human tissues PMID: 14741047
    17. confinement of SULT2B1b to the granular layer coincides with this being the area with the highest cholesterol sulfate content suggesting that the physiologic action of cholesterol sulfate is likely carried out in this region of the living epidermis PMID: 15140224
    18. Immunohistochemical localization of SULT2B1b in human tissues showed expression in the cytoplasm of ciliated columnar or cuboidal epithelial cells in terminal bronchia. PMID: 15878639
    19. Of five Sp1 elements identified in SULT2B1, two had regulatory activity utilizing immortalized human keratinocytes. PMID: 15953604
    20. SULT2B1b, by acting on a variety of oxysterols, offers a potential pathway for modulating in vivo the injurious effects of these compounds. PMID: 17347498
    21. Results show SULT2B1 polymorpohisms affect enzyme functions. PMID: 17496163
    22. SULT2B1 is involved in reulating prostate cell responsiveness to dehydroepiandrosterone and delta5-androstenediol. PMID: 17626250
    23. Data show that SULT2B1b is localized in cytosol and nuclei of cancerous and normal breast tissue, and that African Americans had significantly more SULT2B1b in nuclei of epithelial cells of normal breast tissue compared to Caucasians. PMID: 18586095

    顯示更多

    收起更多

  • 相關疾病：
    Ichthyosis, congenital, autosomal recessive 14 (ARCI14)
  • 亞細胞定位：
    Cytoplasm, cytosol. Microsome. Nucleus.
  • 蛋白家族：
    Sulfotransferase 1 family
  • 組織特異性：
    Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
  • 數據庫鏈接：

    HGNC: 11459

    OMIM: 604125

    KEGG: hsa:6820

    STRING: 9606.ENSP00000201586

    UniGene: Hs.369331



主站蜘蛛池模板： 无码人妻丝袜在线视频| 国产果冻豆传媒麻婆精东| 2019午夜福利不卡片在线| 少妇高潮毛片免费看| 隔壁老王国产在线精品| 2019久久视频这里有精品15| 成人免费大片黄在线观看com| 人妻丰满熟妇av无码区| 成人片黄网站色大片免费| 亚洲理论在线a中文字幕| 鲁一鲁av2019在线| 国外亚洲成av人片在线观看| 亚洲国产aⅴ成人精品无吗| 国精产品999一区二区三区有限| 国产精品白丝av网站| 国产精品一区二区久久不卡| 无码国产精成人午夜视频一区二区 | 扒开双腿吃奶呻吟做受视频 | 欧美99久久无码一区人妻a片| 四房播色综合久久婷婷| 久久只精品99品免费久23| 中文字幕无码第1页| 久久人妻无码中文字幕| 亚洲美女视频高清在线看| 欧美 日韩版国产在线播放| 日韩av激情在线观看| 国产xxxx69真实实拍| 国产精品18久久久久久欧美| 欧美极品少妇×xxxbbb| 躁躁躁日日躁| 人妻丰满熟妇av无码片| 色欲天天婬色婬香综合网| 青青草97国产精品免费观看| 久久九九精品99国产精品| 裸体女人高潮毛片| 一本久久知道综合久久| 99精品国产兔费观看久久99| 蜜芽av无码精品国产午夜| 少妇精品久久久一区二区三区| 国产精品熟妇视频国产偷人| 国产亚洲精品福利视频在线观看 |