在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SULT2B1 Antibody

SULT2B1 Antibody

  • 中文名稱：
    SULT2B1兔多克隆抗體
  • 貨號：
    CSB-PA158594
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA158594(SULT2B1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 60 μg, Lane: 231 cells, Primary antibody: CSB-PA158594(SULT2B1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SULT2B1
  • 別名：
    Alcohol sulfotransferase antibody; EC 2.8.2.2 antibody; HSST2 antibody; Hydroxysteroid sulfotransferase 2 antibody; ST2B1 antibody; ST2B1_HUMAN antibody; Sulfotransferase 2B1 antibody; Sulfotransferase family cytosolic 2B member 1 antibody; SULT2B1 antibody; SULT2B1a antibody; SULT2B1b antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human SULT2B1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation.; Sulfonates pregnenolone but not cholesterol.
  • 基因功能參考文獻：
    1. findings showed clearly the impact of genetic polymorphisms on the cholesterol-sulphating activity of SULT2B1b allozymes, which may underscore the differential metabolism of cholesterol in individuals with different SULT2B1b genotypes PMID: 29701841
    2. Mutation in SULT2B1 leads to an autosomal-recessive congenital ichthyosis phenotype via increased proliferation of human keratinocytes, thickening of epithelial layers, and altered epidermal cholesterol metabolism. PMID: 28575648
    3. Since 1'-hydroxyestragole exposure readily produced DNA injury in B-13/H cells, these data suggest that cholangiocarcinomas generated in rats fed estragole may be dependent, in part, on SULT2B1 activation of the 1'-hydroxyestragole metabolite. PMID: 26739637
    4. Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma. PMID: 26121319
    5. This study identified specific germline variations in estradiol metabolism-related pathways, namely CYP1B1, SULT2B1, and HSD17B2, as novel prognostic markers that are cumulatively associated with increased risk of prostate cancer progression PMID: 24682418
    6. The SULT2B1 isoforms have a unique 50 amino acid carboxy-terminal sequence that is not present in the other human SULT isoforms (review). PMID: 24020383
    7. Data indicate that cholesterol sulfate (CS) and SULT2B1b inhibited gluconeogenesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (HNF4alpha) in both cell cultures and human SULT2B1b transgenic mice. PMID: 24277929
    8. SULT2B1 is induced by calcitriol activated vitamin D receptor in human prostate cancer cells. PMID: 23579488
    9. SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of HCC. PMID: 23593328
    10. In HT29 cells expression of SULT2B1 was enhanced by probiotic fermentation supernatants without aleurone. PMID: 21840698
    11. The Ca(2+)-bound form may be physiologically relevant for stressed cells with an elevated free calcium level. PMID: 20329768
    12. The expression of SULT2B1b mRNA in endometrial stromal cells is induced by progesterone and that in endometrial epithelial cells is induced by relaxin via the cAMP pathway. PMID: 19243756
    13. alternative splicing of SULT2B1 results in cholesterol sulfotransferase or pregnenolone sulfotransferase PMID: 12145317
    14. crystal structure of hydroxysteroid sulfotransferases SULT2B1a and SULT2B1b bound to the substrate donor product 3'-phosphoadenosine 5'-phosphate and acceptor substrate pregnenolone revealed a different catalytic binding orientation PMID: 12923182
    15. We have documented the presence of the enzyme (SULT2B1b) that sulfonates cholesterol in human platelets and examined the influence of plasma lipoproteins on the expression and activity of this enzyme PMID: 14676143
    16. Differential subcellular localization of SULT2B1b in prostate and placenta suggests that SULT2B1b may be differentially regulated and have different physiological functions in these two hormonally responsive human tissues PMID: 14741047
    17. confinement of SULT2B1b to the granular layer coincides with this being the area with the highest cholesterol sulfate content suggesting that the physiologic action of cholesterol sulfate is likely carried out in this region of the living epidermis PMID: 15140224
    18. Immunohistochemical localization of SULT2B1b in human tissues showed expression in the cytoplasm of ciliated columnar or cuboidal epithelial cells in terminal bronchia. PMID: 15878639
    19. Of five Sp1 elements identified in SULT2B1, two had regulatory activity utilizing immortalized human keratinocytes. PMID: 15953604
    20. SULT2B1b, by acting on a variety of oxysterols, offers a potential pathway for modulating in vivo the injurious effects of these compounds. PMID: 17347498
    21. Results show SULT2B1 polymorpohisms affect enzyme functions. PMID: 17496163
    22. SULT2B1 is involved in reulating prostate cell responsiveness to dehydroepiandrosterone and delta5-androstenediol. PMID: 17626250
    23. Data show that SULT2B1b is localized in cytosol and nuclei of cancerous and normal breast tissue, and that African Americans had significantly more SULT2B1b in nuclei of epithelial cells of normal breast tissue compared to Caucasians. PMID: 18586095

    顯示更多

    收起更多

  • 相關疾病：
    Ichthyosis, congenital, autosomal recessive 14 (ARCI14)
  • 亞細胞定位：
    Cytoplasm, cytosol. Microsome. Nucleus.
  • 蛋白家族：
    Sulfotransferase 1 family
  • 組織特異性：
    Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
  • 數據庫鏈接：

    HGNC: 11459

    OMIM: 604125

    KEGG: hsa:6820

    STRING: 9606.ENSP00000201586

    UniGene: Hs.369331



主站蜘蛛池模板： 麻豆av传媒蜜桃天美传媒| 一本一道人人妻人人妻αv| 免费国产黄网站在线观看动图| 伊人亚洲综合影院首页| 在线看片免费人成视频影院看| 偷柏自拍亚洲综合在线| 日韩精品视频一区二区三区| 丰满诱人的人妻3| 国产女人高潮抽搐叫床视频| 男女免费观看在线爽爽爽视频| 精品无人区无码乱码毛片国产| 校园春色~综合网| 日本亚洲欧洲另类图片| 色偷偷色噜噜狠狠网站年轻人 | 无码人妻一区、二区、三区免费视频 | 国产成人综合色视频精品| 麻豆国产原创视频在线播放| 亚洲精品乱码久久久久久自慰 | 伊人无码一区二区三区| 粗大猛烈进出高潮视频| 国产人久久人人人人爽| 日韩乱码人妻无码中文字幕久久| 色妺妺免费影院| 又黄又爽的60分钟视频| 图片小说视频一区二区| 色婷婷五月综合久久| 人妻无码中文字幕永久在线| 在线成人精品国产区免费| 国产成人精品综合久久久久| 天堂网www在线资源最新版| 久久不见久久见免费视频下载| 乱色熟女综合一区二区三区| 风韵犹存丰满大屁股熟妇| 日韩欧美国产一区精品| 日韩av高清在线看片| 亚洲国色天香卡2卡3卡4| 无套内射chinesehd熟女| 草的我好爽视频| 极品少妇hdxx麻豆hdxx| 国产偷窥熟精品视频| 国产亚洲精品成人aa片|