在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

STX11 Antibody

  • 中文名稱:
    STX11兔多克隆抗體
  • 貨號:
    CSB-PA695180
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA695180(STX11 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA695180(STX11 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse lung tissue, Primary antibody: CSB-PA695180(STX11 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    STX11
  • 別名:
    FHL4 antibody; HLH4 antibody; HPLH4 antibody; Stx11 antibody; STX11_HUMAN antibody; Syntaxin 11 antibody; Syntaxin-11 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human STX11
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
  • 基因功能參考文獻:
    1. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID: 29044293
    2. The results suggest that STX11 plays an important role in the pathogenesis of Peripheral T-cell lymphomas and they may contribute to the future development of new drugs for the treatment of Peripheral T-cell lymphomas. PMID: 26176172
    3. a pivotal role for S-acylation in the function of syntaxin 11 in NK cells PMID: 24910990
    4. Stx11 functions as a t-SNARE for the final fusion of LG at the IS. PMID: 24227526
    5. Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. PMID: 23160464
    6. These data indicate that human neutrophils express syntaxin 11 and call attention to the possible involvement of neutrophils in familial hemophagocytic lymphohistiocytosis pathology PMID: 19259622
    7. Platelets deficient in syntaxin-11 from a Familial Hemophagocytic Lymphohistiocytosis type 4 had secretion defect. PMID: 22767500
    8. Data suggest that syntaxin 11 promotes the fusion of Rab27a-expressing vesicles with cytotoxic granules and reveal additional complexity in spatial/temporal segregation of subcellular structures involved in granule-mediated cytotoxicity. PMID: 21342435
    9. No detrimental mutations were identified in STX11 in Chinese children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. PMID: 21674762
    10. STX11 should be sequenced in HLH patients even when impaired NK cell degranulation is not found PMID: 21298754
    11. a novel homozygous deletion (c. 581_584delTGCC; p.Leu194ProfsX2) in the gene-encoding syntaxin 11 (STX11), causing a premature termination codon in hemophagocytic lymphohistiocytosis PMID: 19967551
    12. The mutations in STX11 are responsible for HLH in approximately 1% of North American patients and can cause variable defects in syntaxin 11 expression and function with resultant impact on clinical phenotype. PMID: 20486178
    13. A large group of 63 unrelated patients with Familial hemophagocytic lymphohistiocytosis (FHL) was analysed for mutations in STX11, PRF1, and UNC13D. PMID: 16278825
    14. Defective cytotoxic lymphocyte degranulation is associated with syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 patients PMID: 17525286
    15. Syntaxin 11 plays a role in natural killer (NK) cell granule exocytosis and in the generation of cell-mediated killing. PMID: 17785771
    16. DNA methylation of Stx11 contribute to disease susceptibility at the 6q24 locus in humans. PMID: 19169743
    17. Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11 PMID: 19804848

    顯示更多

    收起更多

  • 相關疾病:
    Familial hemophagocytic lymphohistiocytosis 4 (FHL4)
  • 亞細胞定位:
    Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
  • 蛋白家族:
    Syntaxin family
  • 數據庫鏈接:

    HGNC: 11429

    OMIM: 603552

    KEGG: hsa:8676

    STRING: 9606.ENSP00000356540

    UniGene: Hs.118958



主站蜘蛛池模板: 亚洲人成网线在线播放| 99久久精品国产一区二区三区| 狠狠久久噜噜熟女| aaa欧美色吧激情视频| 国产尤物精品自在拍视频首页| 国产亚洲视频中文字幕97精品| 国产激情艳情在线看视频| 日韩精品毛片无码一区到三区| 日日碰狠狠躁久久躁96| 久热这里在线精品| 中字幕一区二区三区乱码| 白天躁晚上躁麻豆视频| 欧美人与动牲交zooz男人| 精品国内自产拍在线观看 | 成人性三级欧美在线观看| 青青草国产免费国产是公开| 亚洲精品黑牛一区二区三区| 自拍偷在线精品自拍偷无码专区 | 久久久久久人妻精品一区| 久久精品国产99国产精品澳门| 无码高潮又爽又黄a片软件| 日本一上一下爱爱免费| 在线视频观看免费视频18| 国产一区二区女内射| 老司机久久99久久精品播放免费| 久久午夜无码鲁丝片直播午夜精品 | 免费的污污的网站在线观看| 色135综合网| 色妞精品av一区二区三区| 亚洲成在人网站无码天堂| 日本精品高清一区二区| 欧美深性狂猛ⅹxxx深喉| 偷窥国产亚洲免费视频| 内射女校花一区二区三区| 久久久精品波多野结衣| 中文字幕人妻a片免费看| 777米奇色狠狠俺去啦| 欧美日韩一区二区综合| 欧美极品少妇性运交| 国产片免费福利片永久| 无码毛片aaa在线|