在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

STX11 Antibody

  • 中文名稱:
    STX11兔多克隆抗體
  • 貨號:
    CSB-PA022889GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    STX11
  • 別名:
    FHL4 antibody; HLH4 antibody; HPLH4 antibody; Stx11 antibody; STX11_HUMAN antibody; Syntaxin 11 antibody; Syntaxin-11 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human STX11
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
  • 基因功能參考文獻:
    1. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID: 29044293
    2. The results suggest that STX11 plays an important role in the pathogenesis of Peripheral T-cell lymphomas and they may contribute to the future development of new drugs for the treatment of Peripheral T-cell lymphomas. PMID: 26176172
    3. a pivotal role for S-acylation in the function of syntaxin 11 in NK cells PMID: 24910990
    4. Stx11 functions as a t-SNARE for the final fusion of LG at the IS. PMID: 24227526
    5. Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. PMID: 23160464
    6. These data indicate that human neutrophils express syntaxin 11 and call attention to the possible involvement of neutrophils in familial hemophagocytic lymphohistiocytosis pathology PMID: 19259622
    7. Platelets deficient in syntaxin-11 from a Familial Hemophagocytic Lymphohistiocytosis type 4 had secretion defect. PMID: 22767500
    8. Data suggest that syntaxin 11 promotes the fusion of Rab27a-expressing vesicles with cytotoxic granules and reveal additional complexity in spatial/temporal segregation of subcellular structures involved in granule-mediated cytotoxicity. PMID: 21342435
    9. No detrimental mutations were identified in STX11 in Chinese children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. PMID: 21674762
    10. STX11 should be sequenced in HLH patients even when impaired NK cell degranulation is not found PMID: 21298754
    11. a novel homozygous deletion (c. 581_584delTGCC; p.Leu194ProfsX2) in the gene-encoding syntaxin 11 (STX11), causing a premature termination codon in hemophagocytic lymphohistiocytosis PMID: 19967551
    12. The mutations in STX11 are responsible for HLH in approximately 1% of North American patients and can cause variable defects in syntaxin 11 expression and function with resultant impact on clinical phenotype. PMID: 20486178
    13. A large group of 63 unrelated patients with Familial hemophagocytic lymphohistiocytosis (FHL) was analysed for mutations in STX11, PRF1, and UNC13D. PMID: 16278825
    14. Defective cytotoxic lymphocyte degranulation is associated with syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 patients PMID: 17525286
    15. Syntaxin 11 plays a role in natural killer (NK) cell granule exocytosis and in the generation of cell-mediated killing. PMID: 17785771
    16. DNA methylation of Stx11 contribute to disease susceptibility at the 6q24 locus in humans. PMID: 19169743
    17. Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11 PMID: 19804848

    顯示更多

    收起更多

  • 相關疾病:
    Familial hemophagocytic lymphohistiocytosis 4 (FHL4)
  • 亞細胞定位:
    Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
  • 蛋白家族:
    Syntaxin family
  • 數據庫鏈接:

    HGNC: 11429

    OMIM: 603552

    KEGG: hsa:8676

    STRING: 9606.ENSP00000356540

    UniGene: Hs.118958



主站蜘蛛池模板: 看成年女人午夜毛片免费| 久久午夜无码鲁丝片| 欧美肥老太交性506070| 在线精品国产成人综合| 久久婷婷五月综合色丁香| 成人午夜看黄在线尤物成人 | 中文字幕乱码亚洲精品一区| 欧美毛多水多黑寡妇| 熟妇丰满大屁股在线播放| 欧美日韩亚洲国产在线制服| 色综合久久网| 欧美大浪妇猛交饥渴大叫| 女人被躁到高潮免费视频| 久热爱精品视频线路一| 精品人妻无码一区二区色欲产成人 | 亚洲综合无码av一区二区三区| 在线观看无码av免费不卡软件| 少妇人妻邻居| 国产丝袜足j在线视频播放| 亚洲 一区二区 在线| 天天狠天天透天天伊人| 亚洲精品国产精品国自产观看| 西西人体大胆瓣开下部毛茸茸| 中文字幕亂倫免賛視頻| 国产欧美日韩va另类在线播放| 久久婷婷五月综合色丁香| 永久免费的av在线电影网| 潮喷无码正在播放| 久久av无码精品人妻糸列| 女人被狂躁到高潮视频免费软件| 精品无人区码一码二码三码区别| 久久久国产乱子伦精品| 亚洲色婷婷一区二区三区| 亚洲人av在线无码影院观看| 精品性影院一区二区三区内射| 亚洲国产精品一区二区www| 女人被弄到高潮的免费视频| 97色伦综合在线欧美视频| 国产 日韩 中文字幕 制服| 亚洲成a∨人片在线观看不卡| 日韩 欧美 国产 一区三|