在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

STRADA Antibody

  • 中文名稱:
    STRADA兔多克隆抗體
  • 貨號:
    CSB-PA745759ESR1HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA745759ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA745759ESR1HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) STRADA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    STRADA antibody; LYK5 antibody; STRAD antibody; STE20-related kinase adapter protein alpha antibody; STRAD alpha antibody; STE20-related adapter protein antibody; Serologically defined breast cancer antigen NY-BR-96 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human STE20-related kinase adapter protein alpha protein (25-210AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
  • 基因功能參考文獻(xiàn):
    1. We identified for the first time a homozygous point mutation in STRADA causing PMSE. Additional bi-allelic mutations related to PMSE thus far have not been observed in Baylor approximately 6,000 consecutive clinical WES cases, supporting the rarity of this disorder. PMID: 27170158
    2. aberrant nuclear accumulation of LKB1 caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis PMID: 20424326
    3. Several novel splice isoforms of STRADalpha that differentially affect the kinase activity, complex assembly, subcellular localization of LKB1 and the activation of the LKB1-dependent AMPK pathway were discovered. PMID: 17921699
    4. study describes structure of the core heterotrimeric LKB1-STRADalpha-MO25alpha complex, revealing an unusual allosteric mechanism of LKB1 activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 function PMID: 19892943
    5. Identification and characterization of an LKB1-specific adaptor protein and substrate, STRAD. Results imply that STRAD plays a key role in regulating the tumor suppressor activities of LKB1. PMID: 12805220
    6. identify a multifactored mechanism to control LKB1 localization, and they suggest that the STRADbeta-LKB1 complex might possess unique functions in the nucleus PMID: 18256292
    7. LKB1 deacetylation is regulated by SIRT1 and that this in turn influences its intracellular localization, association with STRAD, kinase activity, and ability to activate AMPK. PMID: 18687677
    8. ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 activation. PMID: 19513107

    顯示更多

    收起更多

  • 相關(guān)疾病:
    A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.
  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 30172

    OMIM: 608626

    KEGG: hsa:92335

    STRING: 9606.ENSP00000336655

    UniGene: Hs.514402



主站蜘蛛池模板: 无码国产精品一区二区免费式芒果| 国产性色av一区二区三区| 思思久久99热只有频精品66| 久久精品中文字幕无码绿巨人| 亚洲精品亚洲人成在线观看| 小小拗女性bbwxxxx国产| 自拍偷在线精品自拍偷免费| 乱人伦人妻中文字幕无码久久网| 三级在线看中文字幕完整版| 亚洲精品无码久久久久yw| 中文字幕欧美亚州视频免费 | 高潮射精日本韩国在线播放| 与子敌伦刺激对白播放| 中国国语毛片免费观看视频| 亚洲中文字幕在线无码一区二区| 欧美丰满肥婆videos| 在线观看精品视频网站| 公么大龟弄得我好舒服秀婷视频| 日日摸天天摸爽爽狠狠97| 精品国产一区二区三区久久狼| 国产作爱视频免费播放| 波多野结衣办公室双飞| 精品成人免费一区二区不卡| 免费三级现频在线观看播放| 色一情一乱一乱一区99av白浆| 国产熟妇与子伦hd| 99热国产这里只有精品9| 无码视频免费一区二区三区| 久久av无码αv高潮αv喷吹| 国产精久久一区二区三区| 久久精品国产一区二区免费| 久久精品夜夜夜夜夜久久| av怡红院一区二区三区| 99re6热精品视频在线观看| 免费无码va一区二区三区| 国产精品va在线观看无码不卡| 日本另类αv欧美另类aⅴ| 成人免费无码大片a毛片抽搐色欲| 国产亚洲精品久久久久5区| 亚洲中文字慕日产2021| 毛片免费全部播放无码|