在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

STRADA Antibody

  • 中文名稱:
    STRADA兔多克隆抗體
  • 貨號:
    CSB-PA235298
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HepG2 cells, using STRAD antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) STRADA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human STRAD.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
  • 基因功能參考文獻:
    1. We identified for the first time a homozygous point mutation in STRADA causing PMSE. Additional bi-allelic mutations related to PMSE thus far have not been observed in Baylor approximately 6,000 consecutive clinical WES cases, supporting the rarity of this disorder. PMID: 27170158
    2. aberrant nuclear accumulation of LKB1 caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis PMID: 20424326
    3. Several novel splice isoforms of STRADalpha that differentially affect the kinase activity, complex assembly, subcellular localization of LKB1 and the activation of the LKB1-dependent AMPK pathway were discovered. PMID: 17921699
    4. study describes structure of the core heterotrimeric LKB1-STRADalpha-MO25alpha complex, revealing an unusual allosteric mechanism of LKB1 activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 function PMID: 19892943
    5. Identification and characterization of an LKB1-specific adaptor protein and substrate, STRAD. Results imply that STRAD plays a key role in regulating the tumor suppressor activities of LKB1. PMID: 12805220
    6. identify a multifactored mechanism to control LKB1 localization, and they suggest that the STRADbeta-LKB1 complex might possess unique functions in the nucleus PMID: 18256292
    7. LKB1 deacetylation is regulated by SIRT1 and that this in turn influences its intracellular localization, association with STRAD, kinase activity, and ability to activate AMPK. PMID: 18687677
    8. ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 activation. PMID: 19513107

    顯示更多

    收起更多

  • 相關疾病:
    A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.
  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 數據庫鏈接:

    HGNC: 30172

    OMIM: 608626

    KEGG: hsa:92335

    STRING: 9606.ENSP00000336655

    UniGene: Hs.514402



主站蜘蛛池模板: 黄页网站视频免费大全| 真人做人试看60分钟免费| 午夜精品久久久内射近拍高清 | 成人精品动漫一区二区| 波多老师无码av中字专区| 三级全黄的视频在线观看| 国产熟妇按摩3p高潮大叫| 久久国产精品一国产精品| 午夜理论片在线观看免费| 国产一卡二卡四卡无卡免费| 性色做爰片在线观看ww| 国产手机在线国内精品| 亚洲区小说区激情区图片区| 亚洲愉拍二区一区三区| 少妇下面好紧好多水真爽播放| 国内精品久久久久影院嫩草| 久久99国产精品二区| 精品人妻潮喷久久久又裸又黄| 波多野结衣中文字幕一区二区三区| 国产极品美女高潮抽搐免费网站| 尤物国精品午夜福利视频| 粉嫩极品国产在线观看| 又爽又黄又无遮挡的视频| 医院人妻闷声隔着帘子被中出| 成人一在线视频日韩国产| 国产精品系列无码专区| 黑人大荫蒂老太大| 久久香蕉国产线看观看怡红院妓院 | 国产成人精品综合在线观看| 久久精品国产亚洲欧美| 色婷婷亚洲一区二区综合| 国产又黄又猛又粗又爽的a片动漫| 日韩人妻无码制服丝袜视频| 国产v片在线播放免费无遮挡| 高清视频在线观看一区二区三区| 久久发布国产伦子伦精品| 国产尤物人成免费观看| 日韩一区精品视频一区二区| 国产成人无码专区| 亚洲精品国产成人一区二区| 无码人妻一区二区三区免费n鬼逝|