STK17B Antibody
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中文名稱：STK17B兔多克隆抗體
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貨號：CSB-PA033399
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA033399(STK17B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA033399(STK17B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：DAP kinase related apoptosis inducing protein antibody; DAP kinase related apoptosis inducing protein kinase 2 antibody; DAP kinase-related apoptosis-inducing protein kinase 2 antibody; Death associated protein kinase related 2 antibody; DRAK 2 antibody; DRAK2 antibody; Serine/threonine kinase 17b antibody; Serine/threonine kinase 17b apoptosis inducing antibody; Serine/threonine protein kinase 17B antibody; Serine/threonine-protein kinase 17B antibody; ST17B_HUMAN antibody; STK 17B antibody; Stk17b antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human STK17B
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Phosphorylates myosin light chains. Acts as a positive regulator of apoptosis.
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基因功能參考文獻：
- ChIP assays showed that in U937 cells MYB binds to a conserved element upstream of the DRAK2 transcription start site. PMID: 23398943
- DRAK2 protein directly binds to the type I TGF-beta receptor and Knockdown of DRAK2 suppresses the tumorigenic ability of breast cancer cells. PMID: 23122956
- DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation. PMID: 21148796
- DRAK2 kinase activity is regulated in a calcium-dependent manner and that Ser(12) phosphorylation is necessary for optimal suppression of T cell activation by this kinase PMID: 17182616
- Strong suppression of T cell receptor signals during thymic selection caused by ectopic DRAK2 expression in a DRAK2 transgenic mouse model of autoimmune encephalomyelitis alters the responsiveness of peripheral T cells. PMID: 19542440
- Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. PMID: 19638987
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亞細胞定位：Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment.
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蛋白家族：Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
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組織特異性：Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.
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數據庫鏈接：
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