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  4. STK17B Antibody

STK17B Antibody

  • 中文名稱：
    STK17B兔多克隆抗體
  • 貨號：
    CSB-PA574347
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from mouse brain cells, using STK17B antibody.
    • Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using STK17B antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) STK17B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human STK17B.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Phosphorylates myosin light chains. Acts as a positive regulator of apoptosis.
  • 基因功能參考文獻：
    1. ChIP assays showed that in U937 cells MYB binds to a conserved element upstream of the DRAK2 transcription start site. PMID: 23398943
    2. DRAK2 protein directly binds to the type I TGF-beta receptor and Knockdown of DRAK2 suppresses the tumorigenic ability of breast cancer cells. PMID: 23122956
    3. DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation. PMID: 21148796
    4. DRAK2 kinase activity is regulated in a calcium-dependent manner and that Ser(12) phosphorylation is necessary for optimal suppression of T cell activation by this kinase PMID: 17182616
    5. Strong suppression of T cell receptor signals during thymic selection caused by ectopic DRAK2 expression in a DRAK2 transgenic mouse model of autoimmune encephalomyelitis alters the responsiveness of peripheral T cells. PMID: 19542440
    6. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. PMID: 19638987

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  • 亞細胞定位：
    Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
  • 組織特異性：
    Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.
  • 數據庫鏈接：

    HGNC: 11396

    OMIM: 604727

    KEGG: hsa:9262

    STRING: 9606.ENSP00000263955

    UniGene: Hs.88297



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