在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

STAG3 Antibody

  • 中文名稱:
    STAG3兔多克隆抗體
  • 貨號:
    CSB-PA006704
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of Jurkat cells using STAG3 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    STAG3
  • 別名:
    STAG3 antibody; Cohesin subunit SA-3 antibody; SCC3 homolog 3 antibody; Stromal antigen 3 antibody; Stromalin-3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human STAG3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
  • 基因功能參考文獻:
    1. c.677C > G associated with primary ovarian insufficiency PMID: 28802712
    2. Loss of STAG2 or STAG3, which encode subunits of the cohesin complex, in melanoma cells results in resistance to BRAF inhibitors (BRAFi). Loss-of-function mutations in STAG2, as well as decreased expression of STAG2 or STAG3 proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines. PMID: 27500726
    3. STAG3 truncating variant as the cause of primary ovarian insufficiency has been found in two sisters in a consanguineous Lebanese family. PMID: 26059840
    4. We identified a homozygous 1-bp deletion inducing a frameshift mutation in STAG3 on chromosome 7. Female mice devoid of Stag3 are sterile. PMID: 24597867
    5. we show evidence for the involvement of a common allele of STAG3 in the development of epithelial ovarian cancer PMID: 20635389
    6. identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells PMID: 18299561
    7. plays a role in regulation of transcription due to genetic imprinting, sister chromatid exchange, chromosome segregation and as an insulator element. (review) PMID: 18788457

    顯示更多

    收起更多

  • 相關疾病:
    Premature ovarian failure 8 (POF8)
  • 亞細胞定位:
    Nucleus. Chromosome. Chromosome, centromere.
  • 蛋白家族:
    SCC3 family
  • 組織特異性:
    Testis specific.
  • 數據庫鏈接:

    HGNC: 11356

    OMIM: 608489

    KEGG: hsa:10734

    STRING: 9606.ENSP00000319318

    UniGene: Hs.592283



主站蜘蛛池模板: 中文字幕丰满乱子无码视频| 欧洲精品码一区二区三区| 伊人蕉久中文字幕无码专区 | 妺妺窝人体色www看美女| 先锋影音xfyy5566男人资源| 国内精品乱码卡一卡2卡麻豆| 无码国产精品一区二区vr| 任我爽精品视频在线播放| 伊人色综合久久天天| 国产v精品成人免费视频| 人人狠狠综合久久亚洲爱咲| 人妻少妇精品中文字幕av蜜桃| 麻批好紧日起要舒服死了| 一本久道久久综合久久爱| 亚洲全部无码中文字幕| 午夜精品久久久久久毛片| 欧美xxxxx高潮喷水麻豆| 2020国产精品永久在线| 九九久久精品国产波多野结衣| 特级aaaaaaaaa毛片免费视频| 日本高清www午色夜com| 黄网站色成年片在线观看| 亚洲精品专区成人网站| 野花社区在线观看视频| 国产精品乱码一区二区三| 亚洲日韩欧美国产另类综合| 熟女乱亚洲图| 国产成人无码aⅴ片在线观看| 一本久久a久久精品综合| 少妇爆乳无码专区网站| 国产一区二区三区在线观看免费 | 中文无码熟妇人妻av在线| 天堂在线最新版资源www| 国产麻无矿码直接观看| 天天躁日日躁狠狠很躁| 强制高潮18xxxx按摩| 男男又爽又黄又无遮挡网站| 精品无码国产污污污免费网站| 亚洲色在线v中文字幕| 久久精品免费一区二区三区 | 日韩欧美成人免费观看|