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  4. ST6GALNAC2 Antibody, Biotin conjugated

ST6GALNAC2 Antibody, Biotin conjugated

  • 中文名稱：
    ST6GALNAC2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA883452LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ST6GALNAC2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ST6GALNAC2
  • 別名：
    ST6GALNAC2 antibody; SIAT7B antibody; SIATL1 antibody; STHMAlpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 antibody; EC 2.4.99.3 antibody; GalNAc alpha-2,6-sialyltransferase II antibody; ST6GalNAc II antibody; ST6GalNAcII antibody; SThM antibody; Sialyltransferase 7B antibody; SIAT7-B antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 protein (101-374AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.
  • 基因功能參考文獻(xiàn)：
    1. MicroRNAs miR-135b and miR-182 may reverse the resistance to 5-fluorouracil (5-FU) in colorectal cancer (CRC) cells by targeting ST6GALNAC2 via PI3K/AKT pathway, which render potential chemotherapy targets for the treatment of CRC. PMID: 28767179
    2. miR-182/-135b/ST6GALNAC2/PI3K/AKT axis could function as regulator of progression in colorectal cancer PMID: 29030743
    3. Study provides evidence that mutations in B3GNT2, B4GALT2, and ST6GALNAC2 underlie aberrant glycosylation, and contribute to the pathogenesis of molecular subsets of colon and other gastrointestinal malignancies. PMID: 27004849
    4. Results provide evidence that ST6GalNAcII activated the invasion in follicular thyroid cancer cells through regulating the activity of PI3K/Akt pathway. PMID: 26820593
    5. High expression level of ST6GalNAcII is associated with invasive phenotype of breast cancer. PMID: 24756995
    6. ST6GalNAc II might be participated in the glycosylation of Axl, and this Axl glycosylation may mediate the tumorigenicity, invasion, and distant metastasis of breast phyllodes tumor cells. PMID: 24961352
    7. Results identified the sialyltransferase ST6GalNAc2 as a novel breast cancer metastasis suppressor. PMID: 24520024
    8. Il-6 and Il-4 reduced galactosylation of the O-glycan substrate directly via decreased expression of the galactosyltransferase C1GalT1 and, indirectly, via increased expression of the sialyltransferase ST6GalNAc-II PMID: 24398680
    9. ST6GalNAc2 is a novel enzyme that regulates leukocyte adhesion under fluid shear PMID: 23548905
    10. Expression of the ST6-GalNAcII gene and activity of the CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase were higher in immunoglobulinA1-producing cell lines. PMID: 17418236
    11. the ADG haplotype in the ST6GALNAC2 gene is a functional regulatory variant that may contribute to the genetic susceptibility in a subset of patients in whom the desialylation of IgA1 molecules was the main causative pathogenesis of IgAN PMID: 17480010
    12. reduced sialylation of serum IgA1 may result from decreased expression of ST6GALNAC2. PMID: 19170967
    13. potential genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgA nephropathy PMID: 19357720

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  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 組織特異性：
    Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10867

    OMIM: 610137

    KEGG: hsa:10610

    STRING: 9606.ENSP00000225276

    UniGene: Hs.592105



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