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  4. SSX2IP Antibody, Biotin conjugated

SSX2IP Antibody, Biotin conjugated

  • 中文名稱：
    SSX2IP兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA897526LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SSX2IP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ADIP antibody; ADIP_HUMAN antibody; Afadin and alpha actinin binding protein antibody; Afadin DIL domain interacting protein antibody; Afadin DIL domain-interacting protein antibody; Afadin- and alpha-actinin-binding protein antibody; FLJ10848 antibody; KIAA0923 antibody; MGC75026 antibody; OTTHUMP00000011574 antibody; SSX 2 interacting protein antibody; SSX2 interacting protein antibody; SSX2-interacting protein antibody; SSX2IP antibody; Synovial sarcoma X breakpoint 2 interacting protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Afadin- and alpha-actinin-binding protein (485-614AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin. Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling. Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Involved in ciliogenesis. It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia.
  • 基因功能參考文獻：
    1. This study determined the crystallographic structure of human Afadin in complex with LGN. PMID: 26751642
    2. Studied afadin in complex with beta-catenin in glomeruli and in cultured mesangial cells. Found expression of afadin at mesangial intercellular junctions was greatly decreased in mesangial proliferative nephritis in rats & patients w/glomerulonephritis. PMID: 26568295
    3. Knockdown of Wdr8 or hMsd1/SSX2IP displayed very similar mitotic defects, in which spindle microtubules became shortened and misoriented. PMID: 26545777
    4. SSX2IP-mediated microtubule anchoring is essential for proper centriole assembly and duplication. On SSX2IP knockdown, the centriolar satellites become stuck at the microtubule minus end near the centrosome. PMID: 25833712
    5. results showed that SSX2IP promotes the development and metastasis of hepatocellular carcinoma and contributes to the drug resistance of hepatoma cells PMID: 23452395
    6. Nuclear protein SS2IP interacts with cancer-related protein SSX2 and the human homologue of a Ras-like GTPase interactor, RABIN3. PMID: 12007189
    7. data shows that SSX2IP is affected in two ways that relate to the cell cycling of acute myeloid leukaemia cells PMID: 18028484

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  • 亞細胞定位：
    Cell junction, adherens junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    ADIP family
  • 組織特異性：
    Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain
  • 數據庫鏈接：

    HGNC: 16509

    OMIM: 608690

    KEGG: hsa:117178

    STRING: 9606.ENSP00000340279

    UniGene: Hs.22587



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