在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SRGN Antibody, Biotin conjugated

  • 中文名稱:
    SRGN兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA022664ED01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SRGN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SRGN
  • 別名:
    Chondroitin sulfate proteoglycan core protein antibody; Cytolytic granule proteoglycan core protein antibody; FLJ12930 antibody; gp600 antibody; Hematopoetic proteoglycan core protein antibody; Mastocytoma proteoglycan core protein antibody; MGC9289 antibody; OTTHUMP00000019716 antibody; P.PG antibody; PG19 core protein antibody; Pgsg antibody; Platelet proteoglycan core protein antibody; platelet proteoglycan protein core antibody; PLATELET PROTEOGLYCAN PROTEIN CORE; PPG antibody; PPG antibody; PRG antibody; PRG1 antibody; PROTEOGLYCAN 1 antibody; proteoglycan 1; secretory granule antibody; Proteoglycan 10K core protein antibody; Proteoglycan peptide core protein antibody; PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE antibody; secretory granule proteoglycan 1 antibody; Secretory granule proteoglycan core peptide antibody; Secretory granule proteoglycan core protein antibody; Serglycin antibody; serglycin proteoglycan antibody; Sgc antibody; Srgn antibody; SRGN_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Serglycin protein (28-154AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
  • 基因功能參考文獻(xiàn):
    1. SRGN overexpression promoted colorectal cancer cell migration and invasion and SRGN was physically binding to a hypoxia response element in its promoter region. PMID: 30121667
    2. SRGN secreted by tumor cells and stromal components in the TME promotes malignant phenotypes through interacting with tumor cell receptor CD44 PMID: 27819672
    3. Extracellular spce serglycin upregulated CD44 receptor expression to maintain nasopharyngeal carcinoma stemness by interacting with CD44 and activating the MAPK/beta-catenin pathway. PMID: 27809309
    4. SRGN expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    5. Patients with NPC with tumors showing strong tumor intensity and low infiltrated percentage of tumor-infiltrated lymphocytes with serglycin may be at high risk for distant metastases. PMID: 24995621
    6. The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression PMID: 26581653
    7. These results suggest functions for serglycin in endothelial cells trough interactions with partner molecules, in biological processes with relevance for diabetic complications, cardiovascular disease and cancer development. PMID: 26694746
    8. These results suggest that different signaling pathways are involved in regulating secretion of serglycin and partner molecules in activated endothelial cells. PMID: 24513305
    9. The reduced expression of SRGN was accompanied by elevated levels of E-cadherin. PMID: 23996242
    10. These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM. PMID: 24403068
    11. These results suggest that human epicardial adipose tissue (EAT) has strong inflammatory properties in patients with coronary artery disease and provide novel evidence that serglycin is an adipocytokine highly expressed in EAT. PMID: 23376071
    12. Cell-surface SRGN promotes the adhesion of myeloma cells to collagen type I. PMID: 23387827
    13. This review covers recent studies on the involvement of serglycin in various pathological conditions, as well as its roles in immunity, hemostasis, cell growth, apoptosis, and reproduction. PMID: 22807344
    14. Human granulocyte precursors transfected with siRNA against serglycin displayed reduced capability to retain fully processed HNP-1. PMID: 21849484
    15. Serglycin regulates NPC metastasis via autocrine and paracrine routes, and that it serves as an independent prognostic indicator of metastasis-free survival and disease-free survival in NPC patients. PMID: 21289131
    16. Serglycin secreted by human multiple myeloma cell lines inhibits both the classical and lectin pathways of complement, without influencing alternative pathway activity. PMID: 21268013
    17. Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. PMID: 21075844
    18. proapoptotic granzyme is exocytosed predominantly as a macromolecular complex with serglycin PMID: 12388539
    19. cell- and differentiation-specific alterations in chromatin structure may control serglycin gene expression PMID: 14506241
    20. serglycin-bound granzyme B in high-molecular-weight degranulate material from cytotoxic T lymphocytes predominantly followed a dynamin-dependent pathway to kill target cells PMID: 14739229
    21. mechanism of delivery is proposed entailing electrostatic transfer of granzyme B from serglycin to cell surface proteins PMID: 15788411
    22. Serglycin release is a constitutive process, which may be of fundamental biological importance in the study of multiple myeloma. PMID: 16870619
    23. Serglycin is of importance for secretory processes in human monocytes. PMID: 17909965
    24. Mutations in SRGN is not associated with familial hemophagocytic lymphohistiocytosis PMID: 18000860

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasmic granule. Cytolytic granule. Secreted, extracellular space. Golgi apparatus.
  • 蛋白家族:
    Serglycin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9361

    OMIM: 177040

    KEGG: hsa:5552

    STRING: 9606.ENSP00000242465

    UniGene: Hs.1908



主站蜘蛛池模板: 中日精品无码一本二本三本| 无码精品国产dvd在线观看9久| 亚洲欧洲日产国码中文字幕| 国产一区二区亚洲精品 | 青青草国产精品免费观看 | 欧美高清在线精品一区| 亚洲久久中文字幕www网站| 成人啪精品视频网站午夜| 国产萌白酱喷水视频在线观看| 婷婷亚洲久悠悠色悠在线播放| 2020国产欧洲精品网站| 中国国产1级毛卡片| 欧美日韩中文国产一区发布| 亚洲色婷婷久久精品av蜜桃| 伊人色综合网一区二区三区| 男女一边摸一边做爽爽的免费阅读 | 97久久超碰国产精品2021| 免费国产黄网站在线观看视频| 人人澡人人曰人人摸看| 欧美做受又硬又粗又大视频| 日本大尺度吃奶呻吟视频| 99热这里只有精品最新地址获取| 国产成人片无码免费视频软件| 手机看片久久国产免费| 一 级做人爱全视频在线看| 亚洲伊人久久大香线蕉| 东京热大乱系列无码| 丰满人妻翻云覆雨呻吟视频| 人人妻人人澡人人爽国产一区 | 国内精品综合久久久40p| 久久久亚洲欧洲日产无码av| 97在线观看播放| 国产亚洲精品久久久久久无几年桃| 日本不卡不码高清视频| 少妇无码av无码专区线y| 色综亚洲国产vv在线观看| 在线观看的网站| 久久亚洲人成电影网| 精品无码人妻一区二区免费蜜桃| 国产久热精品无码激情 | 亚洲国产精品嫩草影院永久 |