在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Serglycin (SRGN)

Recombinant Human Serglycin (SRGN)

  • 中文名稱：
    人SRGN重組蛋白
  • 貨號：
    CSB-YP022664HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SRGN重組蛋白
  • 貨號：
    CSB-EP022664HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SRGN重組蛋白
  • 貨號：
    CSB-EP022664HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SRGN重組蛋白
  • 貨號：
    CSB-BP022664HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SRGN重組蛋白
  • 貨號：
    CSB-MP022664HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SRGN
  • Uniprot No.：
  • 別名：
    Chondroitin sulfate proteoglycan core protein; Cytolytic granule proteoglycan core protein; FLJ12930; gp600; Hematopoetic proteoglycan core protein; Mastocytoma proteoglycan core protein; MGC9289; OTTHUMP00000019716; P.PG; PG19 core protein; Pgsg; Platelet proteoglycan core protein; platelet proteoglycan protein core; PLATELET PROTEOGLYCAN PROTEIN CORE; PPG; PPG; PRG; PRG1; PROTEOGLYCAN 1; proteoglycan 1; secretory granule; Proteoglycan 10K core protein; Proteoglycan peptide core protein; PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE; secretory granule proteoglycan 1; Secretory granule proteoglycan core peptide; Secretory granule proteoglycan core protein; Serglycin; serglycin proteoglycan; Sgc; Srgn; SRGN_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    28-158
  • 氨基酸序列
    YPT RRARYQWVRC NPDSNSANCL EEKGPMFELL PGESNKIPRL RTDLFPKTRI QDLNRIFPLS EDYSGSGFGS GSGSGSGSGS GFLTEMEQDY QLVDESDAFH DNLRSLDRNL PSDSQDLGQH GLEEDFML
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
  • 基因功能參考文獻：
    1. SRGN overexpression promoted colorectal cancer cell migration and invasion and SRGN was physically binding to a hypoxia response element in its promoter region. PMID: 30121667
    2. SRGN secreted by tumor cells and stromal components in the TME promotes malignant phenotypes through interacting with tumor cell receptor CD44 PMID: 27819672
    3. Extracellular spce serglycin upregulated CD44 receptor expression to maintain nasopharyngeal carcinoma stemness by interacting with CD44 and activating the MAPK/beta-catenin pathway. PMID: 27809309
    4. SRGN expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    5. Patients with NPC with tumors showing strong tumor intensity and low infiltrated percentage of tumor-infiltrated lymphocytes with serglycin may be at high risk for distant metastases. PMID: 24995621
    6. The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression PMID: 26581653
    7. These results suggest functions for serglycin in endothelial cells trough interactions with partner molecules, in biological processes with relevance for diabetic complications, cardiovascular disease and cancer development. PMID: 26694746
    8. These results suggest that different signaling pathways are involved in regulating secretion of serglycin and partner molecules in activated endothelial cells. PMID: 24513305
    9. The reduced expression of SRGN was accompanied by elevated levels of E-cadherin. PMID: 23996242
    10. These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM. PMID: 24403068
    11. These results suggest that human epicardial adipose tissue (EAT) has strong inflammatory properties in patients with coronary artery disease and provide novel evidence that serglycin is an adipocytokine highly expressed in EAT. PMID: 23376071
    12. Cell-surface SRGN promotes the adhesion of myeloma cells to collagen type I. PMID: 23387827
    13. This review covers recent studies on the involvement of serglycin in various pathological conditions, as well as its roles in immunity, hemostasis, cell growth, apoptosis, and reproduction. PMID: 22807344
    14. Human granulocyte precursors transfected with siRNA against serglycin displayed reduced capability to retain fully processed HNP-1. PMID: 21849484
    15. Serglycin regulates NPC metastasis via autocrine and paracrine routes, and that it serves as an independent prognostic indicator of metastasis-free survival and disease-free survival in NPC patients. PMID: 21289131
    16. Serglycin secreted by human multiple myeloma cell lines inhibits both the classical and lectin pathways of complement, without influencing alternative pathway activity. PMID: 21268013
    17. Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. PMID: 21075844
    18. proapoptotic granzyme is exocytosed predominantly as a macromolecular complex with serglycin PMID: 12388539
    19. cell- and differentiation-specific alterations in chromatin structure may control serglycin gene expression PMID: 14506241
    20. serglycin-bound granzyme B in high-molecular-weight degranulate material from cytotoxic T lymphocytes predominantly followed a dynamin-dependent pathway to kill target cells PMID: 14739229
    21. mechanism of delivery is proposed entailing electrostatic transfer of granzyme B from serglycin to cell surface proteins PMID: 15788411
    22. Serglycin release is a constitutive process, which may be of fundamental biological importance in the study of multiple myeloma. PMID: 16870619
    23. Serglycin is of importance for secretory processes in human monocytes. PMID: 17909965
    24. Mutations in SRGN is not associated with familial hemophagocytic lymphohistiocytosis PMID: 18000860

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasmic granule. Cytolytic granule. Secreted, extracellular space. Golgi apparatus.
  • 蛋白家族：
    Serglycin family
  • 數據庫鏈接：

    HGNC: 9361

    OMIM: 177040

    KEGG: hsa:5552

    STRING: 9606.ENSP00000242465

    UniGene: Hs.1908



主站蜘蛛池模板： 97人妻人人揉人人躁人人| 欧美真人性做爰一二区| 无码国产69精品久久久孕妇| 亚洲伊人色欲综合网| 在线播放真实国产乱子伦| 国产精品亚洲а∨天堂| 久久久亚洲精品一区二区三区| 久久精品99久久香蕉国产色戒| 中文成人无码精品久久久不卡 | 亚洲人成网站在小说| 99re久久精品国产| 国产在线拍偷自揄拍无码 | 性xxxxx欧美极品少妇| 野外做受又硬又粗又大视频√| 宅宅少妇无码| 欧美xxxx狂喷水| 无码综合天天久久综合网色吧影院| 亚洲欧美成aⅴ人在线观看| 美女国产毛片a区内射| 国产国产久热这里只有精品 | 久久中文骚妇内射| 影音先锋人妻啪啪av资源网站| 国产免费看又黄又大又污的胸| 日本欧美大码aⅴ在线播放| 国产人妻大战黑人20p| 人妻少妇一区二区三区| 制服视频在线一区二区| 日韩~欧美一中文字幕| 中文字幕精品亚洲无线码二区| 日本一区二区三区免费视频| 久久亚洲精品无码观看不卡| 麻豆视传媒在线观看| 国产精品久久久久久妇女| 国产精品a国产精品a手机版| 午夜亚洲精品久久一区二区| 国产日韩欧美| 亚洲日韩看片无码电影| 国产成av人片在线观看无码| 韩国乱码伦视频免费| 99re6热精品视频在线观看| 亚洲国产成人久久一区|