在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SRGAP1 Antibody

  • 中文名稱:
    SRGAP1兔多克隆抗體
  • 貨號:
    CSB-PA581560
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA581560(SRGAP1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    SRGAP1
  • 別名:
    4930572H05Rik antibody; ARHGAP13 antibody; FLJ22166 antibody; KIAA1304 antibody; RGD1566260 antibody; Rho GTPase activating protein 13 antibody; Rho GTPase-activating protein 13 antibody; SLIT ROBO Rho GTPase activating protein 1 antibody; SLIT-ROBO Rho GTPase-activating protein 1 antibody; SRGAP 1 antibody; srGAP1 antibody; SRGP1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human SRGAP1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
  • 基因功能參考文獻(xiàn):
    1. Results show that the protein expression of srGAP1 is remarkably decreased in 47.5% of colorectal cancer (CRC) tissues compared and is found to be associated with tumor progression and poor prognosis. PMID: 27923383
    2. we identified a consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 x 10(-7)) PMID: 25134534
    3. Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract PMID: 26026792
    4. The elevated miR-145 present in invasive glioblastoma cells (IM3 cells) targets and down-regulated srGAP1, thereby allowing downstream G-proteins to remain in their active state and promote the observed invasive phenotype PMID: 26026080
    5. The interaction of betaPix with srGAP1 is critical for maintaining suppressive crosstalk between Cdc42 and RhoA during 3D collagen migration. PMID: 25150978
    6. Data indicate that srGAP1 possesses a GAP activity specific to Rac1 and is recruited to lamellipodia in a Rac1-dependent manner. PMID: 24006490
    7. genome-wide linkage analysis in populations in Ohio and Poland: Data suggest that missense mutations in SRGAP1 are associated with genetic predisposition to papillary thyroid carcinoma. PMID: 23539728
    8. This study proposed that the expression of SRGAP1 in the anterior neocortex may mark the early location of the human motor cortex, including its corticospinal projection neurons, allowing further study of their early differentiation. PMID: 21060114
    9. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains. PMID: 12736724

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Thyroid cancer, non-medullary, 2 (NMTC2)
  • 組織特異性:
    Expressed in brain, lung, kidney, and testis.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17382

    OMIM: 188470

    KEGG: hsa:57522

    STRING: 9606.ENSP00000347198

    UniGene: Hs.210751



主站蜘蛛池模板: 国内少妇偷人精品视频| 免费刺激性视频大片区| 无码成人片在线播放| 欧美精品18videosex性欧| www夜片内射视频在观看视频| 娇妻玩4p被三个男人伺候电影| 国产乱子伦精品免费无码专区| 国语高潮无遮挡无码免费看| 99精品国产综合久久久久五月天| 欧美黑人巨大xxxxx| 久久精品农村毛片| 日本欧美大码aⅴ在线播放| 蜜臀av性久久久久蜜臀aⅴ| 成av免费大片黄在线观看| 久久精品日日躁夜夜躁欧美| 2021麻豆剧传媒一二三区| 曰本无码人妻丰满熟妇啪啪| 性色av极品无码专区亚洲| 蜜桃一区二区三区| 国产农村老太xxxxhdxx| 无码午夜福利免费区久久| 亚洲国产精品综合久久20| 午夜理论片yy8860y影院| 精品久久国产综合婷婷五月| 伊人久久大香线蕉综合bd高清| 精品亚洲aⅴ无码一区二区三区| 国内精品伊人久久久久影院麻豆| 狠狠色噜噜狠狠狠狠888奇禾| 国产v亚洲v天堂a无码99| 久久99热狠狠色精品一区| 日本新janpanese乱熟| 亚洲人成77777在线播放网站| 日本免费高清线视频免费| 在线视频免费观看爽爽爽| 国产在线精品一区二区夜色| 让少妇爽到高潮视频| 国产精品爽爽久久久久久| 狠狠久久噜噜熟女| 亚洲国产欧美在线观看片不卡| 丰满熟女人妻中文字幕免费| 久在线精品视频线观看|