在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SRGAP1 Antibody

  • 中文名稱:
    SRGAP1兔多克隆抗體
  • 貨號:
    CSB-PA022661GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SRGAP1
  • 別名:
    4930572H05Rik antibody; ARHGAP13 antibody; FLJ22166 antibody; KIAA1304 antibody; RGD1566260 antibody; Rho GTPase activating protein 13 antibody; Rho GTPase-activating protein 13 antibody; SLIT ROBO Rho GTPase activating protein 1 antibody; SLIT-ROBO Rho GTPase-activating protein 1 antibody; SRGAP 1 antibody; srGAP1 antibody; SRGP1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SRGAP1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
  • 基因功能參考文獻:
    1. Results show that the protein expression of srGAP1 is remarkably decreased in 47.5% of colorectal cancer (CRC) tissues compared and is found to be associated with tumor progression and poor prognosis. PMID: 27923383
    2. we identified a consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 x 10(-7)) PMID: 25134534
    3. Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract PMID: 26026792
    4. The elevated miR-145 present in invasive glioblastoma cells (IM3 cells) targets and down-regulated srGAP1, thereby allowing downstream G-proteins to remain in their active state and promote the observed invasive phenotype PMID: 26026080
    5. The interaction of betaPix with srGAP1 is critical for maintaining suppressive crosstalk between Cdc42 and RhoA during 3D collagen migration. PMID: 25150978
    6. Data indicate that srGAP1 possesses a GAP activity specific to Rac1 and is recruited to lamellipodia in a Rac1-dependent manner. PMID: 24006490
    7. genome-wide linkage analysis in populations in Ohio and Poland: Data suggest that missense mutations in SRGAP1 are associated with genetic predisposition to papillary thyroid carcinoma. PMID: 23539728
    8. This study proposed that the expression of SRGAP1 in the anterior neocortex may mark the early location of the human motor cortex, including its corticospinal projection neurons, allowing further study of their early differentiation. PMID: 21060114
    9. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains. PMID: 12736724

    顯示更多

    收起更多

  • 相關疾病:
    Thyroid cancer, non-medullary, 2 (NMTC2)
  • 組織特異性:
    Expressed in brain, lung, kidney, and testis.
  • 數據庫鏈接:

    HGNC: 17382

    OMIM: 188470

    KEGG: hsa:57522

    STRING: 9606.ENSP00000347198

    UniGene: Hs.210751



主站蜘蛛池模板: 国内精品乱码卡一卡2卡三卡新区| 亚洲色成人网站www永久四虎| 成人aa免费视频在线播放| 成 人 黄 色 大片| 激烈的性高湖波多野结衣| 女女女女女裸体处开bbb| 熟女体下毛毛黑森林| 成人无遮羞视频在线观看| 九九九精品成人免费视频| 纯爱无遮挡h肉动漫在线播放| 国产精品自产拍在线观看| 欧美肥熟妇xxxxx| 国产成人av区一区二区三| 蜜臀av色欲a片无码一区二区| 午夜久久久久久禁播电影| 成人精品一区二区三区电影免费| 中文字幕日韩人妻不卡一区| 手机看片久久国产免费| 少妇真实被内射视频三四区| 女人爽到喷水的视频大全| 国产中的精品av一区二区| 在线看亚洲十八禁网站| 久久精品欧美日韩精品| 免费人成网视频在线观看| 亚洲精品无码不卡在线播放| 激情综合色综合啪啪五月丁香| 亚洲欧美中文日韩v日本| 三级无码在钱av无码在钱 | 久久精品无码一区二区三区免费| 亚洲色成人网站www永久四虎| 日本在线看片免费人成视频| 国产亚洲精品自在久久vr| 亚洲国产精品第一区二区| 国产猛男猛女超爽免费视频 | 国内熟妇人妻色无码视频在线| 人人妻人人澡人人爽秒播| 黑人好猛厉害爽受不了好大撑| 精品免费国产一区二区| 九九精品无码专区免费| 国产男女无遮挡猛进猛出| 亚洲 欧美 清纯 校园 另类|