在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SPPL2A Antibody, FITC conjugated

  • 中文名稱:
    SPPL2A兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA855050LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SPPL2A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SPPL2A
  • 別名:
    SPPL2A antibody; IMP3 antibody; PSL2 antibody; PSEC0147 antibody; Signal peptide peptidase-like 2A antibody; SPP-like 2A antibody; SPPL2a antibody; EC 3.4.23.- antibody; Intramembrane protease 3 antibody; IMP-3 antibody; Presenilin-like protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Signal peptide peptidase-like 2A protein (26-172AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis.
  • 基因功能參考文獻:
    1. Study propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 by SPPL2a. PMID: 26987812
    2. In human B cells, SPPL2a is indispensable for turnover of CD74 N-terminal fragment. A human 15q21.2 microdeletion leads to loss of SPPL2a transcript and protein. PMID: 25035924
    3. Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes. PMID: 21896273
    4. ADAM10 and SPPL2a were identified as two proteases implicated in FasL processing and release of the FasL intracellular domain, which has been shown to be important for retrograde FasL signaling PMID: 17557115
  • 亞細胞定位:
    Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
  • 蛋白家族:
    Peptidase A22B family
  • 組織特異性:
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 30227

    OMIM: 608238

    KEGG: hsa:84888

    STRING: 9606.ENSP00000261854

    UniGene: Hs.401537



主站蜘蛛池模板: 欧美激情一区二区三区高清视频| 久久www免费人成_看片中文| 丰满熟妇被猛烈进入高清片| 97免费人妻无码视频| 亚洲综合色在线视频www| 少妇扒开双腿让我看个够| 国产又黄又爽胸又大免费视频| 熟女内射v888av| 无码人妻丰满熟妇区免费| 97色伦综合在线欧美视频| 美国人性欧美xxxx| 成在线人永久免费视频播放 | 97se亚洲国产综合自在线观看| 亚洲va在线va天堂xxxx中文| av无码av在线a∨天堂毛片| 一本色道久久99一综合| 天天天欲色欲色www免费| 色欲综合久久躁天天躁蜜桃| 国产成人av在线影院无毒| 护士奶头又白又大又好摸视频 | 国产成人午夜福利电影在线播放| 色妞www精品视频| 国产无遮挡无码视频免费软件| 亚洲色欲天天天堂色欲网| 精品国产卡一卡2卡3卡| 国产精品18久久久久久vr| 国产黑色丝袜在线观看下| 免费人成网站在线视频| 国产又色又爽又刺激在线播放| 香港三级日本三级妇三级| 99久久国产露脸精品| 吃奶呻吟张开双腿做受在线播放 | 亚洲国产精品无码7777一线| 狠狠色噜噜狠狠狠888米奇 | 国产成人毛片无码视频软件| 精品国偷自产在线视频| 人妻 丝袜美腿 中文字幕| 国产做a爱免费视频在线观看| 国产精品麻豆成人av电影艾秋| 少妇高潮惨叫久久久久久| 亚洲中文字幕av无码区|