在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SPPL2A Antibody, Biotin conjugated

  • 中文名稱:
    SPPL2A兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA855050LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SPPL2A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SPPL2A
  • 別名:
    SPPL2A antibody; IMP3 antibody; PSL2 antibody; PSEC0147 antibody; Signal peptide peptidase-like 2A antibody; SPP-like 2A antibody; SPPL2a antibody; EC 3.4.23.- antibody; Intramembrane protease 3 antibody; IMP-3 antibody; Presenilin-like protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Signal peptide peptidase-like 2A protein (26-172AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis.
  • 基因功能參考文獻:
    1. Study propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 by SPPL2a. PMID: 26987812
    2. In human B cells, SPPL2a is indispensable for turnover of CD74 N-terminal fragment. A human 15q21.2 microdeletion leads to loss of SPPL2a transcript and protein. PMID: 25035924
    3. Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes. PMID: 21896273
    4. ADAM10 and SPPL2a were identified as two proteases implicated in FasL processing and release of the FasL intracellular domain, which has been shown to be important for retrograde FasL signaling PMID: 17557115
  • 亞細胞定位:
    Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
  • 蛋白家族:
    Peptidase A22B family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 30227

    OMIM: 608238

    KEGG: hsa:84888

    STRING: 9606.ENSP00000261854

    UniGene: Hs.401537



主站蜘蛛池模板: 精品国产福利一区二区| 女人裸体做爰免费视频| 999久久欧美人妻一区二区| 无码人妻精品一区二区蜜桃网站| 色翁荡熄又大又硬又粗又视频| 国产看真人毛片爱做a片| 亚洲精品无码av黄瓜影视| 动漫精品专区一区二区三区| av人摸人人人澡人人超碰下载| 大色综合色综合网站| www污污污抽搐喷潮com| 九九精品成人免费国产片| 亚洲国产超清无码专区| 天天摸夜夜添狠狠添婷婷| 中文字幕在线日亚州9| 无码中文人妻在线三区| 亚洲日本中文字幕乱码在线| 欧美另类精品xxxx| 秋霞在线观看秋| 无套熟女av呻吟在线观看| 亚洲va中文字幕无码久久不卡| 无码人妻av一区二区三区波多野| 国内精品人妻无码久久久影院蜜桃| 亚洲无线码在线一区观看| 精品亚洲国产成人av在线时间短的| 午夜无码片在线观看影院y| 无码毛片一区二区本码视频| 真实的国产乱xxxx在线| s级爆乳玩具酱国产vip皮裤 | 成人综合网亚洲伊人| 大地资源在线观看官网第三页| 国产精品老热丝在线观看| 亚洲va久久久噜噜噜久久4399| 男女做爽爽爽视频免费软件| 亚洲欧美午夜理论电影在线观看 | 国产专区国产av| 偷偷做久久久久网站| 97热久久免费频精品99| 一本大道东京热无码一区| 亚洲日韩国产一区二区三区| 日韩精品亚洲色大成网站|